Adverse Factors and the Role of Cisplatin and Vinca Alkaloids for Hearing Impairment in Childhood Cancer Patients and Survivors

Ototoxic Effects of Antineoplastic Drugs: A Systematic Review

“…Chemotherapy, like other cancer treatment modalities, can cause side effects for patients, including ototoxicity. 3,4 Ototoxicity is described as a transitory or permanent disturbance of auditory and vestibular function caused by therapeutic substances, appearing as hearing loss, tinnitus, or vertigo. It is associated with a subset of antineoplastic therapies in cancer patients, including platinum-based chemotherapy, radiation, or surgery involving the ear and vestibulocochlear nerve, as well as supportive care agents such as aminoglycoside antibiotics and loop diuretics, which may also contribute to ototoxicity.…”

“…[10][11][12] Cisplatin is the most often utilized of these medications, and its effects on the cochlea might include sensorineural, bilateral, symmetrical, and irreversible hearing loss. 3 The rate of hearing loss in chemotherapy patients varies widely in the literature due to factors such as frequency of assessment, patient age, medication dosage, drug administration method, and criteria used to detect hearing loss. 13 Other factors that can directly influence chemotherapyinduced ototoxicity include tissue susceptibility to the drug, drug accumulation in the organ, inhibition of normal physiological functions, direct toxic effects on sensory terminal organs, ototoxic synergism, the use of other concomitant ototoxic drugs, and radiation treatment.…”

Effect of melatonin on otoprotection in rodents: a systematic review with meta-analysis

“…Treatment with antineoplastic drugs can cause ototoxicity. 10 , 11 , 12 , 13 , 14 The primary mechanism of cell death induced by these compounds is the generation of Reactive Oxygen Species (ROS) with the induction of apoptosis of the hair cells of the cochlea and vestibule. 15 It is inferred that antioxidant agents counteract this action by promoting otoprotection.…”

Ototoxic effects of antineoplastic drugs: a systematic review

“…3 Chemotherapy, as well as other cancer treatment modalities, may generate side effects for patients, and ototoxicity stands out. 4 , 5 , 6 , 7 , 8 …”