Adverse event of antiepileptic drugs: a cross sectional study

Abstract

Epilepsy is a major non-communicable disorder. Choice between switching to another drug and combining is still debatable when the first antiepileptic drug is ineffective in controlling seizure. Polytherapy usually related with the appearance of adverse effect. This cross sectional study was conducted in Neurology Policlinic with 83 epilepsy patients, consisting of 37 patients used monotherapy and 46 patients used polytherapy. The most common adverse effect was fatigue. Statistical analysis using chi square test showed statistically significant between monotherapy and polytherapy patients against fatigue (p value >0.05). In conclusion, polytherapy is related with the appearance of adverse effect in epilepsy patients.

Antiseizure adverse drug reaction and associated factors among epileptic patients at Jimma Medical Center: a prospective observational study

“…Similarly, in this study patients undergoing polytherapy tended 1.35 times (AOR: 1.35, 95% CI 1.80-2.26) at increased risk of ADR as compared to monotherapy. This finding is potentiated by the other study conducted at the Northwest Ethiopia and Wangaya Regional Hospital in Denpasar 25,39 . This is probably because of overlapping effects and drug interactions ADR increases as the number of co-administered ASD increases.…”

Lip Balm Formulation Based on Balinese Grape seed Oil (Vitis vinifera l. Var Alphonso Lavallee)

“…Irritation is one of adverse reactions that may be occurred to one of the primary constituents of cosmetic formulation or contamination or procedural misconduct. This testing procedure is aimed to prevent unwanted dangerous reaction before applicating to lips [18,19] F. Results of Measurement of Moisture Content To evaluate the effectiveness or ability of lip balm preparations, measurements of water content on the lips of research subjects were carried out before using lip balm preparations (baseline) and after using lip balm which were measured at week I, week II, week III, and week IV using a portable skin analyzer. The research subjects involved in this study were 12 women aged 17-50 years with each group consisting of 2 research subjects who met the inclusion criteria and were willing to participate in this study from beginning to end.…”

Gerakan Keluarga Sadar Obat pada Kelompok Darma Wanita dengan Pendekatan Belajar Aktif

“…Namun, praktek swamedikasi juga dapat membahayakan kesehatan apabila obat-obatan yang didapat tidak digunakan sesuai aturan, terdapat kesalahan informasi penggunaan obat, serta terjadi reaksi obat yang tidak diinginkan. Kesalahan pemilihan obat akibat kesalahan diagnosis juga sering terjadi akibat pemilihan obat yang pada umumnya dipengaruhi oleh pengalaman di masa lalu dan lingkungan sosial (Permatananda et al, 2018;Aswad et al, 2019).…”

“…Pemberian jaminan kesehatan gratis kepada penduduk atau warga di suatu negara tidak serta merta menurunkan praktik swamedikasi, misalnya di Brazil yang ternyata 35% penjualan obat dilakukan secara swamedikasi (Galato et al, 2009). Praktik swamedikasi yang tidak tepat dapat menyebabkan berbagai permasalahan kesehatan, misalnya tidak tercapainya efek pengobatan, timbulnya efek samping, serta munculnya penyakit baru (Permatananda et al, 2018). Beberapa kasus kesehatan serius juga dapat terjadi, yaitu resistansi bakteri, ketergantungan terhadap obat, pendarahan saluran cerna, bahkan peningkatan risiko neoplasma akibat penyalahgunaan obat-obatan tanpa berkonsultasi dengan dokter.…”