Advances in thermosensitive polymer-grafted platforms for biomedical applications

Le, Phung Ngan; Huynh, Khon; Trân, Ngoc Quyên

doi:10.1016/j.msec.2018.02.006

Cited by 63 publications

(35 citation statements)

References 257 publications

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“…Hep-P123 nanogel was formed through a self-assembly process that is governed by the interactions of hydrophobic polymer domains in amphiphilic temperature-sensitive copolymers as the ambient temperature changed. These copolymers have been effectively utilized in drug delivery systems [7,15,20,37,38]. Regarding the Hep-P123 structure, the copolymer exists as a highly negatively-charged platform due to the abundance of anionic groups on the heparin chain.…”

Section: Discussionmentioning

confidence: 99%

“…Regarding the Hep-P123 structure, the copolymer exists as a highly negatively-charged platform due to the abundance of anionic groups on the heparin chain. Such platforms have proven effective in the delivery of positive-charged bioactive molecules [7,20,39]. Ado and IW anticoagulants possessing free amino groups may be protonated to form positive-charged molecules, thus enhancing interaction with Hep-P123 copolymers (as illustrated in Figure 4), which then results in an increase of drug loading efficiency.…”

Section: Discussionmentioning

confidence: 99%

“…Peptides are less stable than ordinary organic compounds, they are prone to hydrolysis and oxidation, have a short lifetime in the body, and are quickly eliminated [4,5]. One of the ways to overcome these disadvantages is the use of peptides in combination with nanomaterials [6,7]. Nanomaterials allow for modifying the properties of compounds without reducing their biological activity.…”

Section: Introductionmentioning

confidence: 99%

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Nanoencapsulation Enhances Anticoagulant Activity of Adenosine and Dipeptide IleTrp

Nguyen

Ivanov

et al. 2019

Nanomaterials

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It is well-known that drugs administered into an organism intravenously or through the gastrointestinal tract are degraded by enzymes of the body, reducing their therapeutic effect. One of the ways to decrease this undesirable process is through the inclusion of drugs in nanomaterials. Earlier strong anticoagulant activity was demonstrated for dipeptide IleTrp (IW) and adenosine (Ado). In this work, the effect of inclusion in nanomaterials on the biological activity of IW and Ado was studied. For this purpose, Ado and IW were incorporated into thermosensitive nanogel composed of pluronic P123-grafted heparin. The prepared nanocarrier was characterized by transmission electron microscopy, dynamic light scattering, and ζ-potential. Biological activity was determined by measuring the bleeding time from mouse tail in vivo and the time of clot formation in vitro. It was found that encapsulation of Ado and IW into nanomaterial significantly increased their effects, resulting in an increase in the bleeding time from mouse tail and clot formation time. Thus, inclusion of low molecular weight anticoagulants Ado and IW into nanomaterials may be considered a way to increase their biological activity. physical protection from environmental stimuli and may target the load to specific sites [8]. Making these systems stimuli-responsive is an efficient way to improve their functions. Use of stimulus-sensitive polymers for the manufacture of smart drug delivery systems and/or active targeting delivery systems may greatly increase the therapeutic efficacy of drugs and biologically active molecules [9,10].Among many other nanomaterials, nanogels can be used as biodegradable and highly efficient carriers for the transportation of drugs and controlled drug release [11,12]. Encapsulation in nanogels is widely used to enhance solubility and stability, e.g., for anticancer drugs. This is especially important for the peptides; loading peptides into nanogel increases their stability and reduces acute toxicity. In fact, several types of nanocarriers have performed their roles in the field very well. Thus, poly(lactide-co-glycolide)-poly(ethylene imine) nanoparticles effectively delivered superoxide dismutase to the cytoplasm via direct translocation and endocytosis-endosomal escape pathways [6]. Mesoporous silica-based nanoparticles have been used for encapsulation and targeted delivery of several proteins and peptides [13]. Along this line, heparin and its derivatives were utilized to deliver many kinds of drugs or bioactive molecules via heparin-drug conjugate, drug-loaded polymeric nanoparticles or nanogels, nanosized complexation, and heparin-coated organic or inorganic nanoparticles [14][15][16]. These heparin-based carriers have been used in various applications, thereby improving the bioavailability and the therapeutic efficacy of drugs or biologically active compounds. The anticoagulant properties of the heparin itself were improved by covalent attachment to the outer surface of the colloidal mesoporous silica nanoparticles [17]. T...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Nanoencapsulation Enhances Anticoagulant Activity of Adenosine and Dipeptide IleTrp

Nguyen

Ivanov

et al. 2019

Nanomaterials

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“…Some biocompatible polymers exhibit a hydrophobic surface, which impairs the desired cellular response. Functionalization through graft polymerization has been extensively studied [157][158][159][160]. The surface graft polymerization method tailors the properties of the polymer through the direct introduction of other types of monomers on the polymeric surface without alteration of the bulk properties [153].…”

Section: Biomedical Polymeric Substratesmentioning

confidence: 99%

Hydroxyapatite Nanoparticle Coating on Polymer for Constructing Effective Biointeractive Interfaces

Galindo

Chai

Tagaya

2019

Journal of Nanomaterials

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Bone is an organic-inorganic composite with the ability to regenerate itself. Thus, several studies based on artificial organic-inorganic interface sciences have been tried to develop capable materials for effective regenerative bone tissues. Hydroxyapatite nanoparticles (HAp NPs) have extensively been researched in bone tissue engineering due to the compositional and shape similarity to the mineral bone and excellent biocompatibility. However, HAp alone has low mechanical strength, which limits its applications. Therefore, HAp NPs have been deposited on the biocompatible polymer matrix, obtaining composites with the enhanced mechanical, thermal, and rheological properties and with higher biocompatibility and bioactivity. For developing new biomedical applications, polymer-HAp interfacial interactions that provide biofusion should be investigated. This paper reviewed common coating techniques for obtaining HAp NPs/polymer fusion interfaces as well as in vitro studies of interfacial interactions with proteins and cells, demonstrating better biocompatibility. Studies based on interfacial interactions between biomolecules and HAp NPs were highlighted, and how these interactions can be affected by specific protein preadsorption was also summarized.

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“…In the past few decades, polysaccharide-based amphiphilic copolymers have been widely studied as drug and gene delivery systems due to their specific interactions with several kinds of bioactive molecules [1,2]. Through the orientation of distinctive segments of these amphiphilic copolymers in aqueous solution, their self-assembly models induce various desirable core-shell platforms with a homogeneous particle size.…”

Section: Introductionmentioning

confidence: 99%

Folate-Conjugated Chitosan-Pluronic P123 Nanogels: Synthesis and Characterizations towards Dual Drug Delivery

Nguyen

Nguyen²,

Dang

et al. 2019

Journal of Nanomaterials

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In this study, a self-assembled nanogel-based pluronic P123-grafted chitosan-folate (CP-FA) was fabricated as a paclitaxel/curcumin codelivery system. 1 H-NMR and TGA proved that the fabricating method of CP-FA was successful. Dynamic light scattering (DLS), zeta potentials, and transmission electron microscopy (TEM) exposed that CP-FA nanoparticles had a uniform size with a diameter of around 16:27 ± 2:01 nm in the colloidal solution and had better sustainable stability at a lower concentration than P123 due to the moderate positive potential value (39:43 ± 3:45 mV) and the lower critical micelle concentration (0.036 mg/ml). Dual drugs were loaded with CP-FA nanogels via self-assembly by the hydrophobic interaction between both hydrophobic therapeutic compounds (PTX and Cur) and the hydrophobic segment of the P123 copolymer. The high hydrophobicity of the segment induced a great loading efficacy of up to 98:63 ± 0:42 of PTX and 97:82 ± 0:48 of Cur. In addition, the CP-FA nanogels exposed superior effects in a controlled release of these encapsulated therapeutic compounds for a long period of time. The anticancer activity of the dual-drug delivery system was evaluated using human breast cancer cell lines (MCF-7) via the IC50 value to compare with the PTX-loading CP-FA nanogel. The obtained results suggested that CP-FA/PTX-Cur displayed a remarkable improvement in anticancer activity at an IC50 value of 5:74 ± 0:23 nM which was higher than that of CP-FA/PTX (IC50 = 8:20 ± 1:41 nM) due to the synergistic effect of both PTX and Cur. Thereby, a dual-drug deliverysystem-based CP-FA of PTX and Cur has been proposed as a promising candidate in cancer therapy.

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Advances in thermosensitive polymer-grafted platforms for biomedical applications

Cited by 63 publications

References 257 publications

Nanoencapsulation Enhances Anticoagulant Activity of Adenosine and Dipeptide IleTrp

Nanoencapsulation Enhances Anticoagulant Activity of Adenosine and Dipeptide IleTrp

Hydroxyapatite Nanoparticle Coating on Polymer for Constructing Effective Biointeractive Interfaces

Folate-Conjugated Chitosan-Pluronic P123 Nanogels: Synthesis and Characterizations towards Dual Drug Delivery

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