Advances in systemic therapy for advanced pancreatobiliary malignancies

Abstract

Pancreatobiliary malignancies are relatively uncommon and the overall prognosis is poor. Treatment options for advanced disease are limited to systemic therapy for metastatic disease and a combination of systemic therapy and radiation therapy for locally advanced but unresectable tumors. There have been significant advances in the treatment of pancreatobiliary cancers in recent years but the prognosis for patient survival remains disappointingly poor. We review the current treatment options for locally advanced pancreatobiliary malignancies and highlight recent advances in systemic therapy, including novel approaches using targeted treatments.

Diagnostic Accuracy and Cytomorphological Analysis of Biliary Brush and Endoscopic Ultrasound Guided Fine Needle Aspiration (EUS-FNA) of the pancreas based on The Papanicolaou Society of Cytopathology System

“…Keganasan pankreatobilier merupakan keganasan yang jarang terjadi namun memiliki prognosis yang buruk akibat penegakan diagnosis yang terlambat dengan estimasi angka kesintasan 5 tahun sekitar 2-5%. 1,2 Berdasarkan data Badan Registrasi Kanker Perhimpunan Dokter Spesialis Patologi Indonesia tahun 2015 terdapat 32.471 kasus keganasan dengan 80 kasus diantaranya merupakan keganasan pankreas dan 71 kasus saluran empedu. 3 Keganasan pankreatobilier menjadi penyebab nomor 7 kematian akibat kanker di dunia.…”

“…4,5 Peningkatan kasus keganasan pankreatobilier diprediksi akan meningkat sebanyak 355.317 kasus baru pada tahun 2050, disebabkan karena diketahuinya faktor risiko potensial penyebab kanker pankreas dan deteksi dini diagnosis kanker pankreas. 2,4 Berdasarkan hal tersebut, penegakan diagnosis awal yang tepat sangat penting dalam meningkatkan keberhasilan terapi.…”

A Case of Pregnant Female Detected with Ampullary Carcinoma, the Course of the Disease and Pregnancy after Pancreaticoduodenectomy (Whipple’s Procedure)

“…Approximately 80% of the patients have locally advanced or metastatic pancreatic carcinoma at the time of diagnosis [1] . One of the important reasons of poor prognosis and increased mortality includes late diagnosis [4] . Our patient didn't have any of the known risk factors for occurrence of ampullary cancer.…”

“…A mpullary and pancreatic carcinoma have high mortality rates particularly among the solid tumors [1][2][3] . The median survival of untreated metastatic and locally advanced ampullary and pancreatic carcinoma are 3-5 and 6-10 months respectively [4] . The worldwide mortality due to these types of malignancies is increasing with more reported cases from the Middle East and North Africa [5] .…”

Initial human experience of endoscopic ultrasound-guided photodynamic therapy with a novel photosensitizer and a flexible laser-light catheter

“…Interest has been increasing in the use of locoregional treatments as part of a multimodality approach to the management of locally advanced pancreaticobiliary malignancies [1]. Photodynamic therapy (PDT) is a widely accepted way of producing selective tissue necrosis or apoptosis in patients with cholangiocarcinoma [2].…”