Advances in murine models of breast cancer bone disease

Ottewell, Penelope D.; Lawson, Michelle A.

doi:10.20517/2394-4722.2021.14

Cited by 2 publications

(1 citation statement)

References 52 publications

(129 reference statements)

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“…Lung Osteolytic, Osteoblastic 29,30 Osteolytic, Osteoblastic 30 Breast Osteolytic, Osteoblastic 31,32 Osteolytic, Osteoblastic 33 Thyroid Osteolytic Prostate Osteoblastic 43,44 Osteolytic, Osteoblastic 45 Treatment with radium-223, a radioisotope emitting α-particles, targets osteoblastic lesions. 57,58 This mechanism works by using exogenous radium-223 which is chemically related to calcium and is deposited by activated osteoblasts adjacent to cancer cells.…”

Section: Prevalent Lesions In Humans Xenograft Modelsmentioning

confidence: 99%

The dynamic microenvironment associated with metastatic bone disease: Current concepts

Bhale¹,

Ghosh²,

Theriault³

et al. 2023

Journal of Surgical Oncology

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Patients with bone metastases may experience debilitating pain, neurological conditions, increased risk of pathological fractures, and death. A deeper understanding of the bone microenvironment, the molecular biology of cancer types prone to metastasis, and how bone physiology promotes cancer growth, may help to uncover targeted treatment options. The purpose of this paper is to outline the current concepts relevant to topics including bone remodeling, angiogenesis, and immunomodulation as it relates to metastatic bone disease.

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Section: Prevalent Lesions In Humans Xenograft Modelsmentioning

confidence: 99%

The dynamic microenvironment associated with metastatic bone disease: Current concepts

Bhale¹,

Ghosh²,

Theriault³

et al. 2023

Journal of Surgical Oncology

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The progressive trend of modeling and drug screening systems of breast cancer bone metastasis

Kolahi Azar,

Gharibshahian,

Rostami

et al. 2024

J Biol Eng

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Bone metastasis is considered as a considerable challenge for breast cancer patients. Various in vitro and in vivo models have been developed to examine this occurrence. In vitro models are employed to simulate the intricate tumor microenvironment, investigate the interplay between cells and their adjacent microenvironment, and evaluate the effectiveness of therapeutic interventions for tumors. The endeavor to replicate the latency period of bone metastasis in animal models has presented a challenge, primarily due to the necessity of primary tumor removal and the presence of multiple potential metastatic sites.The utilization of novel bone metastasis models, including three-dimensional (3D) models, has been proposed as a promising approach to overcome the constraints associated with conventional 2D and animal models. However, existing 3D models are limited by various factors, such as irregular cellular proliferation, autofluorescence, and changes in genetic and epigenetic expression. The imperative for the advancement of future applications of 3D models lies in their standardization and automation. The utilization of artificial intelligence exhibits the capability to predict cellular behavior through the examination of substrate materials' chemical composition, geometry, and mechanical performance. The implementation of these algorithms possesses the capability to predict the progression and proliferation of cancer. This paper reviewed the mechanisms of bone metastasis following primary breast cancer. Current models of breast cancer bone metastasis, along with their challenges, as well as the future perspectives of using these models for translational drug development, were discussed.

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Advances in murine models of breast cancer bone disease

Cited by 2 publications

References 52 publications

The dynamic microenvironment associated with metastatic bone disease: Current concepts

The dynamic microenvironment associated with metastatic bone disease: Current concepts

The progressive trend of modeling and drug screening systems of breast cancer bone metastasis

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