2000
DOI: 10.1016/s0734-9750(00)00039-2
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Advances in enzymatic transformation of penicillins to 6-aminopenicillanic acid (6-APA)

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Cited by 114 publications
(53 citation statements)
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“…3.5.1.11) is used as a bulk enzyme in the production of 6 aminopenicillanic acid (6-APA) by hydrolysis of penicillin G or V (Shewale and Sudhakaran, 1997;Parmar et al 2000) and more recently in the synthesis of 6-APA and 7 amino-desacetoxycephalosporanic acid (7-ADCA) derived semi-synthetic penicillins and cephalosporins (Illanes and Wilson, 2006;Du et al 2009;Pchelintsev et al 2009). Biocatalyst engineering has been a central issue in penicillin acylase biocatalysis (Kallenberg et al 2005;Chandel et al 2008); substantial improvements in penicillin acylase stabilization have been obtained by directed immobilization to solid supports (Basso et al 2003;Montes et al 2007;Sun et al 2009), aggregation (Rajendhran and Gunasekaran, 2007), site-directed mutagenesis and directed evolution (Rajendhran and Gunasekaran, 2004;Serra et al 2009), and functional screening (Gabor et al 2005).…”
mentioning
confidence: 99%
“…3.5.1.11) is used as a bulk enzyme in the production of 6 aminopenicillanic acid (6-APA) by hydrolysis of penicillin G or V (Shewale and Sudhakaran, 1997;Parmar et al 2000) and more recently in the synthesis of 6-APA and 7 amino-desacetoxycephalosporanic acid (7-ADCA) derived semi-synthetic penicillins and cephalosporins (Illanes and Wilson, 2006;Du et al 2009;Pchelintsev et al 2009). Biocatalyst engineering has been a central issue in penicillin acylase biocatalysis (Kallenberg et al 2005;Chandel et al 2008); substantial improvements in penicillin acylase stabilization have been obtained by directed immobilization to solid supports (Basso et al 2003;Montes et al 2007;Sun et al 2009), aggregation (Rajendhran and Gunasekaran, 2007), site-directed mutagenesis and directed evolution (Rajendhran and Gunasekaran, 2004;Serra et al 2009), and functional screening (Gabor et al 2005).…”
mentioning
confidence: 99%
“…They are the most widely used β-lactam antibiotics, with a share of about 19 % of the estimated world-wide antibiotic market. (43) In particular, they are effective against the microorganisms responsible for several diseases such as tetanus, diphtheria, syphilis, gonorrhoea and skin boils. Penicillin acylase catalyses the hydrolysis of penicillin G (PG) to phenyl acetic acid (PAA) and 6-aminopenicillanic acid (6-APP) (Figure 10), (44) which is the building block for production of semi-synthetic β-lactam antibiotics, (45) as shown in Table 2.…”
Section: A) Penicillin Acylasementioning
confidence: 99%
“…Enzyme immobilization is proven to be one of the key steps in making the enzymatic processes economically practicable (Cao and Schmid 2005;Zhou 2009). According to the study of Parmar et al (2000), it is also found that the immobilized enzyme catalyst with the improved activity and stability can reduce the production cost. Cross-linking enzyme aggregate (CLEA) is described as the latest enzyme immobilization technology (Barbosa et al 2014;Brady and Jordaan 2009;Sheldon et al 2005).…”
Section: Introductionmentioning
confidence: 99%