Advances in Electrochemical Aptasensors Based on Carbon Nanomaterials

Evtugyn, Gennady; Porfireva, Anna; Shamagsumova, Rezeda V.; Hianik, Tibor

doi:10.3390/chemosensors8040096

Cited by 36 publications

(24 citation statements)

References 229 publications

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“…However, current metal-oxide or nitride electrode sensors [10][11][12] are only possible in high-temperature environments. Carbon-based nanostructures have attracted significant attention in academia as a fabulous tool for developing gas sensors [13,14] which have good prospects for low-energy consumption and cost-effective properties.…”

Section: Introductionmentioning

confidence: 99%

Self-Assembled Corn-Husk-Shaped Fullerene Crystals as Excellent Acid Vapor Sensors

Wei

Song

et al. 2022

Chemosensors

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Low-molecular-weight acid vapors cause aging and destruction in material processing. In this paper, facile fabrication of novel corn-husk-shaped fullerene C60 crystals (CHFCs) through the dynamic liquid–liquid interfacial precipitation method is reported. The CHFCs were grown at the liquid–liquid interface between isopropyl alcohol (IPA) and a saturated solution of C60 in mesitylene under ambient temperature and pressure conditions. The average length, outer diameter, and inner diameter of CHFCs were ca. 2.88 μm, 672 nm, and 473 nm, respectively. X-ray diffraction (XRD) analysis showed the CHFCs exhibit a mixed face-centered cubic (fcc) and hexagonal-close pack (hcp) crystal phases with lattice parameters a = 1.425 nm, V = 2.899 nm3 for fcc phase and a = 2.182 nm, c = 0.936 nm, a/c ratio = 2.33, and V = 3.859 nm3 for hcp phase. The CHFCs possess mesoporous structure as confirmed by transmission electron microscopy (TEM) and nitrogen sorption analysis. The specific surface area and the pore volume were ca. 57.3 m2 g−1 and 0.149 cm3 g−1, respectively, are higher than the nonporous pristine fullerene C60. Quartz crystal microbalance (QCM) sensing results show the excellent sensing performance CHFCs sensitive to acetic acid vapors due to the enhanced diffusion via mesoporous architecture and hollow structure of the CHFCs, demonstrating the potential of the material for the development of a new sensor system for aliphatic acid vapors sensing.

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Section: Introductionmentioning

confidence: 99%

Self-Assembled Corn-Husk-Shaped Fullerene Crystals as Excellent Acid Vapor Sensors

Wei

Song

et al. 2022

Chemosensors

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“…They provide unprecedentedly high specific surface areas up to 2630 m 2 /g [75] and 1315 m 2 /g [76], respectively, combined with a high electrical conductivity and charge carrier mobility. A number of reviews have discussed the perspectives of graphene and carbon nanomaterial application as materials for electrodes to improve electrochemical sensors [77][78][79], including foodborne pathogen detection [80].…”

Section: Carbon Nanomaterialsmentioning

confidence: 99%

Advances in Nanomaterials-Based Electrochemical Biosensors for Foodborne Pathogen Detection

et al. 2021

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Electrochemical biosensors utilizing nanomaterials have received widespread attention in pathogen detection and monitoring. Here, the potential of different nanomaterials and electrochemical technologies is reviewed for the development of novel diagnostic devices for the detection of foodborne pathogens and their biomarkers. The overview covers basic electrochemical methods and means for electrode functionalization, utilization of nanomaterials that include quantum dots, gold, silver and magnetic nanoparticles, carbon nanomaterials (carbon and graphene quantum dots, carbon nanotubes, graphene and reduced graphene oxide, graphene nanoplatelets, laser-induced graphene), metal oxides (nanoparticles, 2D and 3D nanostructures) and other 2D nanomaterials. Moreover, the current and future landscape of synergic effects of nanocomposites combining different nanomaterials is provided to illustrate how the limitations of traditional technologies can be overcome to design rapid, ultrasensitive, specific and affordable biosensors.

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“…Nevertheless, the 5′-end is frequently used for attachment, considering that modifications at this position are performed at the final stage of oligonucleotide synthesis, which improves yield and simplifies purification [ 19 ]. The additional incorporation of spacer groups between the oligonucleotide sequence and the attachment point can improve the aptamers’ conformational flexibility, ultimately leading to an enhanced sensitivity [ 19 , 76 , 91 , 92 ]. Several spacers, such as alkyl chains, polyethylene glycol (PEG), hexamethyldiamine (HMDA), or oligothymidine sequences (of all the DNA bases, thymidine displays the lowest nonspecific binding), proved to facilitate analyte recognition and binding [ 19 , 76 , 91 , 92 ].…”

Section: Strategies In Electrochemical Aptasensor Design: Aptamer Immobilization and Electrochemical Signal Generationmentioning

confidence: 99%

“…The additional incorporation of spacer groups between the oligonucleotide sequence and the attachment point can improve the aptamers’ conformational flexibility, ultimately leading to an enhanced sensitivity [ 19 , 76 , 91 , 92 ]. Several spacers, such as alkyl chains, polyethylene glycol (PEG), hexamethyldiamine (HMDA), or oligothymidine sequences (of all the DNA bases, thymidine displays the lowest nonspecific binding), proved to facilitate analyte recognition and binding [ 19 , 76 , 91 , 92 ]. Still, it should be borne in mind that a spacer group can potentially alter the aptamer’s secondary structure and, therefore, influence its affinity for the target molecule [ 19 ].…”

Section: Strategies In Electrochemical Aptasensor Design: Aptamer Immobilization and Electrochemical Signal Generationmentioning

confidence: 99%

The Role of Aryldiazonium Chemistry in Designing Electrochemical Aptasensors for the Detection of Food Contaminants

Raicopol

Pilan

2021

Materials

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Food safety monitoring assays based on synthetic recognition structures such as aptamers are receiving considerable attention due to their remarkable advantages in terms of their ability to bind to a wide range of target analytes, strong binding affinity, facile manufacturing, and cost-effectiveness. Although aptasensors for food monitoring are still in the development stage, the use of an electrochemical detection route, combined with the wide range of materials available as transducers and the proper immobilization strategy of the aptamer at the transducer surface, can lead to powerful analytical tools. In such a context, employing aryldiazonium salts for the surface derivatization of transducer electrodes serves as a simple, versatile and robust strategy to fine-tune the interface properties and to facilitate the convenient anchoring and stability of the aptamer. By summarizing the most important results disclosed in the last years, this article provides a comprehensive review that emphasizes the contribution of aryldiazonium chemistry in developing electrochemical aptasensors for food safety monitoring.

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Advances in Electrochemical Aptasensors Based on Carbon Nanomaterials

Cited by 36 publications

References 229 publications

Self-Assembled Corn-Husk-Shaped Fullerene Crystals as Excellent Acid Vapor Sensors

Self-Assembled Corn-Husk-Shaped Fullerene Crystals as Excellent Acid Vapor Sensors

Advances in Nanomaterials-Based Electrochemical Biosensors for Foodborne Pathogen Detection

The Role of Aryldiazonium Chemistry in Designing Electrochemical Aptasensors for the Detection of Food Contaminants

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