Advances in Cancer Therapeutics: Conventional Thermal Therapy to Nanotechnology-Based Photothermal Therapy

Kumari, Sangeeta; Sharma, Nilesh; Sahi, Shivendra V.

doi:10.3390/pharmaceutics13081174

Cited by 70 publications

(49 citation statements)

References 196 publications

(205 reference statements)

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“…With the help of advanced optical imaging technology, real-time dynamic monitoring of molecules in cells and organisms can be carried out, and rapid immunofluorescence analysis of primary infectious disease sources can be carried out. They can provide new technologies and methods for disease occurrence, diagnosis, and treatment research [150].…”

Section: Theranostic Application Of Natural Carbon Nanodotsmentioning

confidence: 99%

Natural Carbon Nanodots: Toxicity Assessment and Theranostic Biological Application

et al. 2021

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This review outlines the methods for preparing carbon dots (CDs) from various natural resources to select the process to produce CDs with the best biological application efficacy. The oxidative activity of CDs mainly involves photo-induced cell damage and the destruction of biofilm matrices through the production of reactive oxygen species (ROS), thereby causing cell auto-apoptosis. Recent research has found that CDs derived from organic carbon sources can treat cancer cells as effectively as conventional drugs without causing damage to normal cells. CDs obtained by heating a natural carbon source inherit properties similar to the carbon source from which they are derived. Importantly, these characteristics can be exploited to perform non-invasive targeted therapy on human cancers, avoiding the harm caused to the human body by conventional treatments. CDs are attractive for large-scale clinical applications. Water, herbs, plants, and probiotics are ideal carbon-containing sources that can be used to synthesize therapeutic and diagnostic CDs that have become the focus of attention due to their excellent light stability, fluorescence, good biocompatibility, and low toxicity. They can be applied as biosensors, bioimaging, diagnosis, and treatment applications. These advantages make CDs attractive for large-scale clinical application, providing new technologies and methods for disease occurrence, diagnosis, and treatment research.

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Section: Theranostic Application Of Natural Carbon Nanodotsmentioning

confidence: 99%

Natural Carbon Nanodots: Toxicity Assessment and Theranostic Biological Application

et al. 2021

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“…In comparison to SWNTs and GO, the non-toxic production process and unique morphology enable SWNHs to have different nano-protein and nano-membrane interaction patterns [51]. Like CNTs and GO, CNHs also lack solubility in aqueous media, which seriously hampered their practical application [52,53]. Unlike the previously mentioned carbon-based nanomaterials, CDs with sizes less than 10 nm and ideal water solubility, as the fourth type of carbon-based nanomaterials, have received considerable attention since they were firstly reported in 2004 [54].…”

Section: Types Of Nirn-lips 21 Liposomes Loading Carbon-based Nanomat...mentioning

confidence: 99%

Design and Application of Near-Infrared Nanomaterial-Liposome Hybrid Nanocarriers for Cancer Photothermal Therapy

et al. 2021

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Liposomes are attractive carriers for targeted and controlled drug delivery receiving increasing attention in cancer photothermal therapy. However, the field of creating near-infrared nanomaterial-liposome hybrid nanocarriers (NIRN-Lips) is relatively little understood. The hybrid nanocarriers combine the dual superiority of nanomaterials and liposomes, with more stable particles, enhanced photoluminescence, higher tumor permeability, better tumor-targeted drug delivery, stimulus-responsive drug release, and thus exhibiting better anti-tumor efficacy. Herein, this review covers the liposomes supported various types of near-infrared nanomaterials, including gold-based nanomaterials, carbon-based nanomaterials, and semiconductor quantum dots. Specifically, the NIRN-Lips are described in terms of their feature, synthesis, and drug-release mechanism. The design considerations of NIRN-Lips are highlighted. Further, we briefly introduced the photothermal conversion mechanism of NIRNs and the cell death mechanism induced by photothermal therapy. Subsequently, we provided a brief conclusion of NIRNs-Lips applied in cancer photothermal therapy. Finally, we discussed a synopsis of associated challenges and future perspectives for the applications of NIRN-Lips in cancer photothermal therapy.

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“…Because of its high specificity and minimally invasive advantages, photothermal therapy (PTT) has recently been a research hotspot among therapeutic techniques for HCC. 6 Photothermal therapy employs a light source with good tissue penetration to irradiate the tumor site. The photosensitizer can transform light energy into heat energy, allowing thermal ablation of the tumor site to be performed.…”

Section: Introductionmentioning

confidence: 99%

Graphene quantum dots mediated magnetic chitosan drug delivery nanosystems for targeting synergistic photothermal-chemotherapy of hepatocellular carcinoma

Chen

Hong

Duan

et al. 2022

Cancer Biology & Therapy

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Conventional clinical monotherapies for advanced hepatocellular carcinoma (HCC) have numerous limitations. Integrated oncology approaches can improve cancer treatment efficacy, and photothermal-chemotherapy drug delivery nanosystems (DDS) based on nanotechnology and biotechnology have piqued the interest of researchers. This study developed an aptamer-modified graphene quantum dots (GQDs)/magnetic chitosan DDS for photothermal-chemotherapy of HCC. The HCC aptamer and the EPR effect of nanoparticles, in particular, enable active and passive targeting of DDS to HCC. GQDs functioned as photosensitizers, effectively moderating photothermal therapy and inhibiting drug release during blood circulation. Magnetic chitosan demonstrated excellent drug encapsulation, acid sensitivity, and tumor imaging capabilities. Proper assembly of the units mentioned above enables precise combined therapy of HCC. This study indicates that DDS can significantly inhibit tumor growth while also extending the survival duration of tumor-bearing mice. The DDS (DOX-Fe 3 O 4 @CGA) shows strong synergistic tumor treatment potential, allowing for the exploration and development of novel HCC therapies.

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Advances in Cancer Therapeutics: Conventional Thermal Therapy to Nanotechnology-Based Photothermal Therapy

Cited by 70 publications

References 196 publications

Natural Carbon Nanodots: Toxicity Assessment and Theranostic Biological Application

Natural Carbon Nanodots: Toxicity Assessment and Theranostic Biological Application

Design and Application of Near-Infrared Nanomaterial-Liposome Hybrid Nanocarriers for Cancer Photothermal Therapy

Graphene quantum dots mediated magnetic chitosan drug delivery nanosystems for targeting synergistic photothermal-chemotherapy of hepatocellular carcinoma

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