Advanced paternal age does not affect embryo aneuploidy following blastocyst biopsy in egg donor cycles

Carrasquillo, Robert; Kohn, Taylor P.; Cinnioğlu, Cengiz; Rubio, Carmen; Simón, Carlos; Ramasamy, Ranjith; Al‐Asmar, Nasser

doi:10.1007/s10815-019-01549-z

Cited by 28 publications

(21 citation statements)

References 56 publications

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“…In a separate study, also using embryos conceived with donor oocytes, these authors found significantly higher rates of aneuploidy 13, 18, and 21 in embryos fertilized with sperm from men > 50 years old in comparison with men 40-49 or ≤ 39 years [44]; rates for men ≥50 were over 14% for all three chromosomes, whereas the highest rate for the other age groups was 6.1% for chromosome 21 in men ≤39. In contrast, Carrasquillo et al evaluated 6934 embryos from 1202 IVF/ICSI egg donor cycles using blastocyst biopsy and found no relationship between APA and embryo aneuploidy [18]. Similarly, a recent South Korean study found no association between paternal age and embryo aneuploidy, whereas significant differences were noted between groups that differed by maternal age [67].…”

Section: Chromosomal Aneuploidymentioning

confidence: 95%

Advanced paternal age: effects on sperm parameters, assisted reproduction outcomes and offspring health

Halvaei

Litzky

Esfandiari

2020

Reprod Biol Endocrinol

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Many factors, including postponement of marriage, increased life expectancy, and improved success with assisted reproductive technologies have been contributing to increased paternal age in developed nations. This increased average paternal age has led to concerns about adverse effects of advanced paternal age on sperm quality, assisted reproductive outcomes, and the health of the offspring conceived by older fathers. This review discusses the association between advanced paternal age and sperm parameters, assisted reproduction success rates, and offspring health.

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Section: Chromosomal Aneuploidymentioning

confidence: 95%

Advanced paternal age: effects on sperm parameters, assisted reproduction outcomes and offspring health

Halvaei

Litzky

Esfandiari

2020

Reprod Biol Endocrinol

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“…The relationship between paternal age and risk of aneuploidy is very controversial in the literature; some studies have found an association (García-Ferreyra et al, 2015;Capelouto et al, 2018), while others have not (Carrasquillo et al, 2019). Our study found an association between increased paternal age and the risk of aneuploidy, and when we evaluated the ROC curve, 36 years was the best cutoff point to predict the risk of aneuploidy.…”

Section: Discussionmentioning

confidence: 42%

Associations among morphological parameters, clinical factors and euploid blastocyst formation

Bilibio¹,

Lorenzzoni²,

Oliveira³

et al. 2021

JBRA Assisted Reproduction

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“…Mechanistically, this age-related increase in aneuploidy is thought to be an effect of the prolonged prophase I arrest in oocytes (a state that can last up to 50 years), which results in gradual degradation of the meiotic apparatus [29]. In contrast, the incidence of aneuploidy does not correlate with paternal age [30,31].…”

Section: Aneuploidymentioning

confidence: 99%

Preimplantation Genetic Testing for Chromosomal Abnormalities: Aneuploidy, Mosaicism, and Structural Rearrangements

Viotti

2020

Genes

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There is a high incidence of chromosomal abnormalities in early human embryos, whether they are generated by natural conception or by assisted reproductive technologies (ART). Cells with chromosomal copy number deviations or chromosome structural rearrangements can compromise the viability of embryos; much of the naturally low human fecundity as well as low success rates of ART can be ascribed to these cytogenetic defects. Chromosomal anomalies are also responsible for a large proportion of miscarriages and congenital disorders. There is therefore tremendous value in methods that identify embryos containing chromosomal abnormalities before intrauterine transfer to a patient being treated for infertility—the goal being the exclusion of affected embryos in order to improve clinical outcomes. This is the rationale behind preimplantation genetic testing for aneuploidy (PGT-A) and structural rearrangements (-SR). Contemporary methods are capable of much more than detecting whole chromosome abnormalities (e.g., monosomy/trisomy). Technical enhancements and increased resolution and sensitivity permit the identification of chromosomal mosaicism (embryos containing a mix of normal and abnormal cells), as well as the detection of sub-chromosomal abnormalities such as segmental deletions and duplications. Earlier approaches to screening for chromosomal abnormalities yielded a binary result of normal versus abnormal, but the new refinements in the system call for new categories, each with specific clinical outcomes and nuances for clinical management. This review intends to give an overview of PGT-A and -SR, emphasizing recent advances and areas of active development.

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Advanced paternal age does not affect embryo aneuploidy following blastocyst biopsy in egg donor cycles

Cited by 28 publications

References 56 publications

Advanced paternal age: effects on sperm parameters, assisted reproduction outcomes and offspring health

Advanced paternal age: effects on sperm parameters, assisted reproduction outcomes and offspring health

Associations among morphological parameters, clinical factors and euploid blastocyst formation

Preimplantation Genetic Testing for Chromosomal Abnormalities: Aneuploidy, Mosaicism, and Structural Rearrangements

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