Advanced paternal age alone does not adversely affect pregnancy or live‐birth rates or sperm parameters following intrauterine insemination

Tatsumi, Takayuki; Ishida, Eri; Tatsumi, Kuniko; Okada, Yumiko; Saito, Toki; Kubota, Toshiro; Saito, Hidekazu

doi:10.1002/rmb2.12222

Cited by 15 publications

(11 citation statements)

References 13 publications

(26 reference statements)

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“…Several recent studies have highlighted the difficulty in separating out APA from AMA. Tatsumi et al analyzed 1576 IUI cycles in women under 40 years old and that paternal age alone, after adjusting for confounding factors, was not associated with pregnancy or live birth rates [113]. The adverse effects of paternal age on IUI outcomes were mostly attributable to maternal age.…”

Section: Iui Outcomementioning

confidence: 99%

Advanced paternal age: effects on sperm parameters, assisted reproduction outcomes and offspring health

Halvaei

Litzky

Esfandiari

2020

Reprod Biol Endocrinol

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Many factors, including postponement of marriage, increased life expectancy, and improved success with assisted reproductive technologies have been contributing to increased paternal age in developed nations. This increased average paternal age has led to concerns about adverse effects of advanced paternal age on sperm quality, assisted reproductive outcomes, and the health of the offspring conceived by older fathers. This review discusses the association between advanced paternal age and sperm parameters, assisted reproduction success rates, and offspring health.

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Section: Iui Outcomementioning

confidence: 99%

Advanced paternal age: effects on sperm parameters, assisted reproduction outcomes and offspring health

Halvaei

Litzky

Esfandiari

2020

Reprod Biol Endocrinol

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“…It is commonly believed that the younger the woman, the higher the pregnancy rate, 7 and the age of the man is not associated with the pregnancy rate, with the age of the woman being the only factor affecting pregnancy. 8 In this study, the pregnancy rate gradually declined with age for women, but there was no significant decline in the pregnancy rate for men until 46 years of age. The ages of the married couples correlates with the pregnancy rate as shown in Fig.…”

Section: Discussionmentioning

confidence: 47%

Treatment outcomes of intrauterine insemination and pregnancy prognosis factors: a retrospective single-center cohort study

Onoue¹,

Baba²,

Koiwa³

et al. 2020

IJFCM

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Although intrauterine insemination (IUI) utilizing the husband's semen is widely used as a general fertility treatment, there are no clear policies determining the appropriate number of IUI cycles or a selection criteria for couples at our institution. In this study we investigated IUIs performed at our facilities in the past 3 years, and examined prognostic factors for pregnancy based on age, number of inseminations, and semen findings. A total of 341 patients who underwent 1,229 cycles of IUIs performed at our institution between January 2016 and December 2018 were included. The pregnancy rate was 6.2% per cycle and 21.1% per couple. In terms of age, we noted both men and women contributed to a decrease in the pregnancy rate with increasing age, but the effects of aging tended to be slightly less pronounced in men. The cumulative pregnancy rate for the number of times insemination was performed was approximately 50% by the second cycle, and 90% by the sixth. Assessment of semen analysis showed significant differences in motility and adjusted recovered sperm concentration (P<0.05).

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“…In our study, unlike these studies, a statistically significant difference was found between pregnancy rates as sperm concentration increased. In a retrospective study including 1576 IUI cycles, it was reported that advanced male age had no effect on pregnancy (11). In our study, since there was no statistically significant difference between male and female ages between the two groups, it was not possible to investigate the effect of advanced male age on pregnancy.…”

Section: Discussionmentioning

confidence: 59%

Effects of Sperm Parameters on Pregnancy Rate in Patients Undergoing Intrauterine Insemination

Solakhan

Demir

2020

Gynecol Obstet Reprod Med

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OBJECTIVE: In this study, the effects of sperm parameters on the success of intrauterine insemination were investigated. STUDY DESIGN: The data from 309 infertile couples who were admitted between 2012-2018 without a female factor were analyzed retrospectively and included in the study. After the administration of gonadotropin and hCG (5000-10000 IU), single insemination was performed in 36-40 hours in all cycles. All couples underwent routine infertility screening. The relationship between sperm parameters (motility, morphology, sperm count), patient age, duration of infertility with intrauterine insemination success was evaluated.RESULTS: There was no statistically significant difference between the two groups in terms of mean age and age related-parity. There was no statistically significant difference between male ages, liquefaction, and sperm volumes between the two groups (p=0.898, p=0.448, p=0.651). Before washing; There was a statistically significant difference between the sperm concentration, percentage of total motile sperm, percentage of progressive motility sperm, percentage of normal sperm morphology, and total sperm count between the two groups (p=0.0001, p=0.0001, p=0.0001, p=0.0001, p=0.0001). After sperm washing; the results were similar to those obtained before washing. While statistically significant difference was observed between sperm volume and sperm concentrations (p=0.023, p=0.018), no significant difference was observed between the two groups in total sperm count (p=0.612).CONCLUSION: As a result, during the application of intrauterine insemination to infertile couples, total motile sperm count, progressive motility sperm count ratio and high sperm ratio with normal morphology used in order to increase pregnancy success can be considered as criteria that increase the chances of success.

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Advanced paternal age alone does not adversely affect pregnancy or live‐birth rates or sperm parameters following intrauterine insemination

Cited by 15 publications

References 13 publications

Advanced paternal age: effects on sperm parameters, assisted reproduction outcomes and offspring health

Advanced paternal age: effects on sperm parameters, assisted reproduction outcomes and offspring health

Treatment outcomes of intrauterine insemination and pregnancy prognosis factors: a retrospective single-center cohort study

Effects of Sperm Parameters on Pregnancy Rate in Patients Undergoing Intrauterine Insemination

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