Advanced glycation endproducts form during ovalbumin digestion in the presence of fructose: Inhibition by chlorogenic acid

Bains, Yasmin; Gugliucci, Alejandro; Caccavello, Russell

doi:10.1016/j.fitote.2017.05.003

Cited by 35 publications

(28 citation statements)

References 42 publications

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“…This formation was both dependent on the type of food products and thermal treatment, as the unheated glucose-lactose-casein meal system did not lead to any intestinal AGE formation [25]. Other studies have also shown intestinal AGE formation: Simulated digestion of ovalbumine with fructose alone produced compounds with a fluorescence spectrum that is characteristic for AGEs [48]. The circumstances under which intestinal AGE formation takes place are not fully understood yet.…”

Section: Formation Of Ages In the Gi Tractmentioning

confidence: 94%

Dietary Advanced Glycation Endproducts and the Gastrointestinal Tract

et al. 2020

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The prevalence of inflammatory bowel diseases (IBD) is increasing in the world. The introduction of the Western diet has been suggested as a potential explanation of increased prevalence. The Western diet includes highly processed food products, and often include thermal treatment. During thermal treatment, the Maillard reaction can occur, leading to the formation of dietary advanced glycation endproducts (dAGEs). In this review, different biological effects of dAGEs are discussed, including their digestion, absorption, formation, and degradation in the gastrointestinal tract, with an emphasis on their pro-inflammatory effects. In addition, potential mechanisms in the inflammatory effects of dAGEs are discussed. This review also specifically elaborates on the involvement of the effects of dAGEs in IBD and focuses on evidence regarding the involvement of dAGEs in the symptoms of IBD. Finally, knowledge gaps that still need to be filled are identified.

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Section: Formation Of Ages In the Gi Tractmentioning

confidence: 94%

Dietary Advanced Glycation Endproducts and the Gastrointestinal Tract

et al. 2020

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“…Researchers recently tested this hypothesis. They found that fructose, as remains in the digestive tract of fructose malabsorbers, forms AGEunder conditions compatible with the intestineswithin a time frame well within the window of digestion, but not with glucose (16,17) . Notably, fructose malabsorption occurs after consumption of foods and beverages with high fructose:glucose ratios, (18)(19)(20)(21) including HFCS (22)(23)(24) , agave syrup (25,26) , crystalline fructose and apple juice (27) , but not after consumption of sucrose or equivalent monomers of fructose and glucose (18)(19)(20)(21) .…”

mentioning

confidence: 99%

Excess free fructose, high-fructose corn syrup and adult asthma: the Framingham Offspring Cohort

DeChristopher

Tucker

2018

Br J Nutr

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There is growing evidence that intakes of high-fructose corn syrup (HFCS), HFCS-sweetened soda, fruit drinks and apple juice - a high-fructose 100 % juice - are associated with asthma, possibly because of the high fructose:glucose ratios and underlying fructose malabsorption, which may contribute to enteral formation of pro-inflammatory advanced glycation end products, which bind receptors that are mediators of asthma. Cox proportional hazards models were used to assess associations between intakes of these beverages and asthma risk, with data from the Framingham Offspring Cohort. Diet soda and orange juice - a 100 % juice with a 1:1 fructose:glucose ratio - were included for comparison. Increasing intake of any combination of HFCS-sweetened soda, fruit drinks and apple juice was significantly associated with progressively higher asthma risk, plateauing at 5-7 times/week v. never/seldom, independent of potential confounders (hazard ratio 1·91, P<0·001). About once a day consumers of HFCS-sweetened soda had a 49 % higher risk (P<0·011), moderate apple juice consumers (2-4 times/week) had a 61 % higher risk (P<0·007) and moderate fruit drink consumers had a 58 % higher risk (P<0·009), as compared with never/seldom consumers. There were no associations with diet soda/orange juice. These associations are possibly because of the high fructose:glucose ratios, and fructose malabsorption. Recommendations to reduce consumption may be inadequate to address asthma risk, as associations are evident even with moderate intake of these beverages, including apple juice - a 100 % juice. The juice reductions in the US Special Supplemental Nutrition Program for Women, Infants, and Children in 2009, and the plateauing/decreasing asthma prevalence (2010-2013), particularly among non-Hispanic black children, may be related. Further research regarding the consequences of fructose malabsorption is needed.

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“…It is estimated that such compounds are 20 000 times more reactive than glucose, and they are the main intermediates during the formation of AGEs in vivo . Therefore, a reduction in total energy intake will likely reduce the availability of substrates, for AGE formation and consequently accumulation within the body . Hence, energy restriction could also contribute to decrease the total pool of AGEs through both lowering glucose levels and limiting substract availability.…”

Section: Discussionmentioning

confidence: 99%

Can advanced glycation end‐products and their receptors be affected by weight loss? A systematic review

et al. 2020

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Advanced glycation end products (AGEs) have been implicated in the pathogenesis of most chronic diseases. Therefore, identification of treatments that can attenuate the effects of these compounds and prevent cardiometabolic complications is of extreme public health interest. Recently, body weight management interventions showed positive results on reducing serum AGE concentrations. Moreover, the soluble receptor for advanced glycation end products (sRAGE) is considered to be a novel biomarker to identify patients with obesity most likely to benefit from weight management interventions. This systematic review aimed to critically analyze papers evaluating the effects of weight loss on serum AGEs and its receptors in adults with excess body weight. MEDLINE, Cochrane, Scopus, and Lilacs databases were searched. Three studies evaluating the response of AGEs to energy-restricted diets and six assessing sRAGE as the primary outcome were included. Energy-restricted diets and bariatric surgery reduced serum AGE concentrations, but effects on endogenous secretory RAGE (esRAGE) and sRAGE concentrations are conflicting. These results may be associated with mechanisms related to changes in dietary intake and limiting endogenous AGE formation. Therefore, the role of energy-restricted diets and bariatric surgery on lowering serum AGE concentrations, as well as its effects on AGEs receptors, deserves further investigation. K E Y W O R D S advanced glycation end product, bariatric surgery, caloric restriction, overweight, sRAGE 1 | BACKGROUND Obesity prevalence has nearly tripled in the past decades, and it has reached epidemic proportions worldwide. According to the World Health Organization in 2016, 39% of the adult population had overweight, and 13% had obesity. 1 Being overweight is a significant risk factor for cardiovascular and metabolic diseases. 2,3 Furthermore, inflammation and oxidative stress are complications associated toAbbreviations: AGEs, advanced glycation end products; RAGE, receptor for advanced glycation end products; NF-kB, nuclear factor kappa B; sRAGE, soluble receptor advanced glycation end products; PRISMA, preferred reporting items for systematic reviews and meta-

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Advanced glycation endproducts form during ovalbumin digestion in the presence of fructose: Inhibition by chlorogenic acid

Cited by 35 publications

References 42 publications

Dietary Advanced Glycation Endproducts and the Gastrointestinal Tract

Dietary Advanced Glycation Endproducts and the Gastrointestinal Tract

Excess free fructose, high-fructose corn syrup and adult asthma: the Framingham Offspring Cohort

Can advanced glycation end‐products and their receptors be affected by weight loss? A systematic review

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