Advanced Drug Delivery Systems in Treating Periodontal Diseases-A Review

Harini, G; Kaarthikeyan, Gurumoorthy

doi:10.9790/0853-13182732

Cited by 9 publications

(12 citation statements)

References 5 publications

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“…From the above studies it can be concluded that the liposomes have unique feature to compartmentalize and solubilize both hydrophilic and hydrophobic materials by nature. This unique feature, coupled with biocompatibility and biodegradability make liposomes very attractive as drug delivery vehicles [80].…”

Section: Liposomesmentioning

confidence: 99%

“…QDs upon stimulation by UV light attaches an antibody to the target cell, and in turn, yield a reactive oxygen species that have the capability of killing the target cells [82]. QDs are used in periodontal therapy to improve the healing of inflamed periodontal tissues [83]. Various quantum dots used for the periodontitis treatment have been listed in Table 4.…”

Section: Quantum Dotsmentioning

confidence: 99%

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Nanotechnology Controlled Local Drug Delivery System for the Treatment of Periodontitis

Garg

Chawla

Pawar³

2018

JAMMR

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Nanotechnology is one of the most promising technologies of the 21 st century. The remarkable application of nanotechnology for targeted site-specific drug delivery has created significant improvements in the bioavailability and bio-distribution of the drugs. There have been various efforts in designing different drug delivery systems for periodontal diseases based on the functionalized nanoparticles. The aim of this article is to review the recent information regarding the experimental progress on nanotechnology in the treatment of various periodontal diseases comprehensively. Novel applications of different types of nanomaterials (nanoparticles to 3D nanostructured scaffolds) for treating periodontal diseases are summarized. Moreover, this paper also focuses on basic principles of utilizing the nanomaterials to create better drug delivery systems for treatment of periodontal diseases. We addressed some queries to electronic databases including, Google Scholar, Google Books, and

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Section: Liposomesmentioning

confidence: 99%

Section: Quantum Dotsmentioning

confidence: 99%

Nanotechnology Controlled Local Drug Delivery System for the Treatment of Periodontitis

Garg

Chawla

Pawar³

2018

JAMMR

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“…Some other roles of QDs are their ability to be embedded into dental resins to tune the emission color of the resin. Lead-free and cadmium-free QDs are employed in periodontal therapy to enhance the healing of inflamed periodontal tissues (Harini and Kaarthikeyan, 2014).…”

Section: Quantum Dots (Qds)mentioning

confidence: 99%

“…The characteristic change in the nanopores conductance enables researchers to be able to electrically elucidate single-molecule kinetic pathways as well as quantify the target easily (Wang et al, 2011). Significant progress has been made in material science and nanotechnology towards designing intelligently gated nanoporous devices (Harini and Kaarthikeyan, 2014).…”

Section: Nanoporesmentioning

confidence: 99%

Roles of Nanotechnological Approaches in Periodontal Disease Therapy

Aminu¹,

Chan²,

Toh³

2017

J App Pharm Sci

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Formulation scientists are faced with a great hurdle of delivering a therapeutic agent into the periodontal pockets because of the anatomical complexity of the route and the lesion's contours that often leads to poor penetration of the drug to the area. However, recent nanotechnology advancement and innovations through nanodentistry are increasingly providing a suitable solution for the treatment of many dental disorders including periodontal disease. These nanodentistry innovative approaches have vowed to revolutionize dental therapeutics by way of using nanomaterials, biotechnology, and nanorobotics, that can significantly influence and transform dental disease's diagnosis, prevention, and treatment. The advances have offered possibilities for providing highquality dental care to a vast number of people around the globe who are currently suffering from periodontal disease. Novel nanotechnology-based carriers and materials such as polymeric nanoparticles, nanogels, nanopores, nanotubes, scaffold matrices, nanoneedles, nanocrystals, quantum dots, nanofibers, and nanofillers have demonstrated promising efficacy and their roles in the disease therapy are of great significance. The aim of this review article is to provide important recent updates on the various nanotechnology-base approaches for periodontal disease therapy. The roles of these recently investigated approaches in the disease treatment are also covered in the review.

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“…On that ground, great efforts are made towards the improvement of allopathic drugs delivery system in the treatment of bone loss provocative diseases, such as endodontic and periodontal diseases. Encapsulation of bioactive materials is employed as an effective and promising technique alongside the use of traditional drug delivery systems, such as injectable gel or films, strips, sponges, compacts and granules [3,4]. Abovementioned materials, for example, calcium phosphate granules, could be difficult to handle and to ensure sufficient contact with bone for further osteoconduction [5].…”

Section: Introductionmentioning

confidence: 99%

Alginate Capsules with Cuttlebone-derived Fillers as an Integrated Solution for Bone Repair

Palaveniene

Lebedevaite

Liesienė

2018

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Alginate capsules with cuttlebone-derived fillers were developed for bone repair applications. Prepared capsules were designed to be suitable for the treatment of small-sized bone loss provocative diseases, such as endodontic and periodontal diseases. Cuttlebone microparticles, as a source of calcium carbonate, or cuttlebone-derived hydroxyapatite microparticles were used as mineral fillers for the preparation of alginate capsules. The capsules were additionally covered with chitosan layer for the hard structure formation and improvement of adhesive properties. Encapsulation efficiency of dexamethasone as a model allopathic drug was 19 %, 24 % and 12 % for capsules with cuttlebone microparticles, capsules with cuttlebonederived hydroxyapatite and capsules without any mineral filler (control group), respectively. We observed that chitosan coating and lyophilisation contributed for the preservation of spherical structure of alginate capsules with mineral fillers. Swelling study of dried capsules in simulated physiological environment (in phosphate buffer saline, pH = 7.2 at 37 °C temperature) showed that average swelling index of alginate-based capsules without mineral fillers was much higher in comparison to capsules with cuttlebone fillers: 121 %, 17 % and 3 % for control group, capsules with cuttlebone microparticles and capsules with cuttlebone-derived hydroxyapatite, respectively.

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Advanced Drug Delivery Systems in Treating Periodontal Diseases-A Review

Cited by 9 publications

References 5 publications

Nanotechnology Controlled Local Drug Delivery System for the Treatment of Periodontitis

Nanotechnology Controlled Local Drug Delivery System for the Treatment of Periodontitis

Roles of Nanotechnological Approaches in Periodontal Disease Therapy

Alginate Capsules with Cuttlebone-derived Fillers as an Integrated Solution for Bone Repair

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