Roles of Nanotechnological Approaches in Periodontal Disease Therapy

Abstract

Formulation scientists are faced with a great hurdle of delivering a therapeutic agent into the periodontal pockets because of the anatomical complexity of the route and the lesion's contours that often leads to poor penetration of the drug to the area. However, recent nanotechnology advancement and innovations through nanodentistry are increasingly providing a suitable solution for the treatment of many dental disorders including periodontal disease. These nanodentistry innovative approaches have vowed to revolutionize dental therapeutics by way of using nanomaterials, biotechnology, and nanorobotics, that can significantly influence and transform dental disease's diagnosis, prevention, and treatment. The advances have offered possibilities for providing highquality dental care to a vast number of people around the globe who are currently suffering from periodontal disease. Novel nanotechnology-based carriers and materials such as polymeric nanoparticles, nanogels, nanopores, nanotubes, scaffold matrices, nanoneedles, nanocrystals, quantum dots, nanofibers, and nanofillers have demonstrated promising efficacy and their roles in the disease therapy are of great significance. The aim of this review article is to provide important recent updates on the various nanotechnology-base approaches for periodontal disease therapy. The roles of these recently investigated approaches in the disease treatment are also covered in the review.

Myrrh mixed with silver nanoparticles demonstrates superior antimicrobial activity against Porphyromonas gingivalis compared to myrrh and silver nanoparticles alone

“…There is a need to prevent P. gingivalis in patients with dental implants by developing approaches to add anti-microbial activity to the implants ( Song and Ge, 2019 ). Hence, not unlike myrrh, silver nanoparticles (SNs) have been studied for their antibacterial effect in different oral health applications, including mouthwash, being added to the dental resin, in the repair of tooth defects, and in toothpaste ( Aminu et al, 2017 ). One study compared SNs that were biosynthesized using the endophytic fungus Fusarium semitectum with two dilutions of CX and saline (placebo); the SN condition performed as well as both CX dilution conditions against P. gingivalis , and all three conditions greatly outperformed the placebo ( Halkai et al, 2018 ).…”