Advanced control of a continuous oscillatory flow crystalliser

Tahir, Furqan; Krzemieniewska-Nandwani, Karolina; Mack, John; Lovett, David; Siddique, Humera; Mabbott, Fraser Adam; Raval, Vishal; Houson, Ian; Florence, Alastair J.

doi:10.1016/j.conengprac.2017.07.008

Cited by 16 publications

(12 citation statements)

References 13 publications

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“…The vessel design also allows for the flexible incorporation of PAT tools and these sensors can be fully integrated to a control system such as PharmaMV to provide closed loop feedback control development and execution. 35,65 Pressure induced slurry transfer between stages was helpful in minimising issues related to transfer line blockages 66 and breakage 13 of crystals that was also as evidenced from the microscopy images of crystals (Fig. 6).…”

Section: Continuous Cooling Crystallisation Of Pcmmentioning

confidence: 81%

“…The PharmaMV Advance Process Control (APC) platform provides an integrated control environment for automation of equipment parameters, collation and archival of process data and the development and operation of real-time model predictive control to automatically control variable process parameters or product attributes. 35…”

Section: Development Of Continuous Crystallisation Platformmentioning

confidence: 99%

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Development and characterisation of a cascade of moving baffle oscillatory crystallisers (CMBOC)

et al. 2020

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Section: Continuous Cooling Crystallisation Of Pcmmentioning

confidence: 81%

Section: Development Of Continuous Crystallisation Platformmentioning

confidence: 99%

Development and characterisation of a cascade of moving baffle oscillatory crystallisers (CMBOC)

et al. 2020

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“…This is the most common approach for process development and commercial manufacturing, but it also has various disadvantages. Batch processes suffer from batch-to-batch variations of the product and potentially high manufacturing costs, due to dead times for charging and cleaning [5][6][7]. To overcome these drawbacks, the crystallization can be carried out continuously, which increases the productivity and especially the space time yield.…”

Section: Introductionmentioning

confidence: 99%

“…To overcome these drawbacks, the crystallization can be carried out continuously, which increases the productivity and especially the space time yield. Hence, continuous operation has received increasing attention in recent years as a key element for improving crystallization based production [7][8][9]. Simple design methods for continuous crystallizations, like for batch-processes, are still missing.…”

Section: Introductionmentioning

confidence: 99%

A Novel Shadowgraphic Inline Measurement Technique for Image-Based Crystal Size Distribution Analysis

et al. 2020

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A novel shadowgraphic inline probe to measure crystal size distributions (CSD), based on acquired greyscale images, is evaluated in terms of elevated temperatures and fragile crystals, and compared to well-established, alternative online and offline measurement techniques, i.e., sieving analysis and online microscopy. Additionally, the operation limits, with respect to temperature, supersaturation, suspension, and optical density, are investigated. Two different substance systems, potassium dihydrogen phosphate (prisms) and thiamine hydrochloride (needles), are crystallized for this purpose at 25 L scale. Crystal phases of the well-known KH2PO4/H2O system are measured continuously by the inline probe and in a bypass by the online microscope during cooling crystallizations. Both measurement techniques show similar results with respect to the crystal size distribution, except for higher temperatures, where the bypass variant tends to fail due to blockage. Thiamine hydrochloride, a substance forming long and fragile needles in aqueous solutions, is solidified with an anti-solvent crystallization with ethanol. The novel inline probe could identify a new field of application for image-based crystal size distribution measurements, with respect to difficult particle shapes (needles) and elevated temperatures, which cannot be evaluated with common techniques.

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“…According to Findeisen and Allgöwer , this can be seen as one of the reasons why linear MPC is widely used in industry. Furthermore, linear methods such as MPC are more feasible to be solved than nonlinear methods for multivariable systems, provided such systems may be represented by linear models , . For crystallization occurring in a multiple‐effect evaporative system, the model must represent the crystallization phenomena at each effect, which increases the number of variables to be computed and the difficulty of representing it as a nonlinear system.…”

Section: Introductionmentioning

confidence: 99%

Application of Model Predictive Control to a Continuous Multiple‐Effect Crystallizer

2018

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An infinite horizon model predictive controller (IHMPC) with zone control is applied to a continuous five-effect evaporative sodium chloride crystallizer. Firstly, a phenomenological dynamic model of the process is developed considering mass, energy, and moment balances coupled to crystallization kinetics. The developed model plays the role of the real system in order to study the proposed optimization/control strategy. The proposed approach is compared to a classical proportional integral derivative (PID) control system. The control strategy based on the prediction of the future state of the plant provides a faster response, a better stability to the process, and a reduction in energy consumption.

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Advanced control of a continuous oscillatory flow crystalliser

Cited by 16 publications

References 13 publications

Development and characterisation of a cascade of moving baffle oscillatory crystallisers (CMBOC)

Development and characterisation of a cascade of moving baffle oscillatory crystallisers (CMBOC)

A Novel Shadowgraphic Inline Measurement Technique for Image-Based Crystal Size Distribution Analysis

Application of Model Predictive Control to a Continuous Multiple‐Effect Crystallizer

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