Advanced Colorectal Cancer Is Associated With Enhanced IL-23 and IL-10 Serum Levels

Stanilov, Noyko; Miteva, Lyuba; Deliysky, Tashko S.; Jovchev, Jovcho P.; Stanilova, Spaska

doi:10.1309/lm7t43aqziupiowz

Cited by 58 publications

(53 citation statements)

References 29 publications

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“…Contradictory results have been reported in studies of Langowski et al, 2006 which showed data that IL-23 promotes tumor incidence and growth in various human cancers. In this respect our results for enhanced serum levels of IL-23 in cancer patients regardless of severity supported the hypothesis that IL-23 promotes tumor development unlike IL-12p70 (Stanilov et al, 2010). Besides, the highest increase in transcriptional activity in tumor samples for IL-23p19 mRNA has been also reported in our study ).…”

Section: Role Of Il-12-related Cytokinessupporting

confidence: 91%

“…Increased level of IL-10 might better control inflammatory responses and cancer development. Results from our study demonstrated a stage dependent association between IL-10 serum level and severity of CRC (Stanilov et al, 2010). The highest IL-10 serum level was found in stage-IV CRC patients, suggesting a pro-tumorigenic activity of systemic IL-10 in CRC progression and play a role in tumor-induced immunosupression in CRC patients.…”

Section: Cytokine Gene Polymorphisms Of Antiinflamatory Cytokines: Tgsupporting

confidence: 48%

“…Additionally, we found the highest level of IL-12p40 in sera from patients with I stage of CRC and significantly lower in patients with more advanced stages. Stanilov et al, 2009;Stanilov et al, 2010). In respect to recent findings regarding different proteins in IL-12 related family which share the p40 subunit, we could attribute the relationship of decreased serum level of IL-12p40 and severity of CRC to the action of Th1-promoting form of IL-12, such as IL-12p70, or free IL-12p40 in monomeric and homodimeric form.…”

Section: Role Of Il-12-related Cytokinesmentioning

confidence: 79%

See 2 more Smart Citations

Cytokine Gene Polymorphisms in Colorectal Cancer

Stanilova¹

2012

Colorectal Cancer Biology - From Genes to Tumor

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Section: Role Of Il-12-related Cytokinessupporting

confidence: 91%

Section: Cytokine Gene Polymorphisms Of Antiinflamatory Cytokines: Tgsupporting

confidence: 48%

Section: Role Of Il-12-related Cytokinesmentioning

confidence: 79%

See 1 more Smart Citation

Cytokine Gene Polymorphisms in Colorectal Cancer

Stanilova¹

2012

Colorectal Cancer Biology - From Genes to Tumor

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“…Available information on IL-10 production in freshly excised human tumors, including carcinomas of the ovary, breast, kidney, lung and skin, including melanoma, has been previously reported (6). In colorectal carcinogenesis, IL-10 promotes rather than inhibits cancer growth, through its immunosuppressive activity (7). Previous studies suggested that increased IL-10 levels may control inflammatory responses and cancer development (8) and constitute a risk factor for carcinogenesis.…”

Section: Introductionmentioning

confidence: 99%

The paradox of IL-10-mediated modulation in cervical cancer

Wang

Liu

et al. 2013

Biomedical Reports

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Abstract. Interleukin-10 (IL-10) has opposing effects as an anti-inflammatory (potentially cancer-promoting) and antiangiogenic (potentially cancer-inhibiting) agent. The role of IL-10 in cervical cancer is also dual. Here, we review the IL-10-mediated tumor-promoting effect and tumor-inhibiting effects in cervical cancer, among which, human papilloma virus (HPV), human leukocyte antigen-G (HLA-G) and IL-10 polymorphisms are associated with the development of cervical cancer. IL-10 is also used for the therapy of cervical cancer through enhancing proliferation, expression of immunologically important surface molecules and increasing Th1 cytokine production and cytotoxic potential in HPV-specific CD8 (+) cytotoxic T lymphocytes.

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“…Other serum colon cancer biomarkers interleukin1β (IL-1β) and interleukin 6 (IL6) were quantified as described by Stanilov et al (2010) using ELISA kits according to instructions of kits manufacturers.…”

Section: Biochemical Analysesmentioning

confidence: 99%

Anticancer Effect of Black Raspberry and Apricot Juice against Colon Cancer Induced by Azoxymethane in Male Rats

Ibrahim¹

2017

Int. J. Adv. Res. Biol. Sci

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This study was carried out to evaluate the anticancer effect of black raspberry juice (RJ) and apricot juice (AJ) against colon cancer induced by Azoxymethane (AOM) in rats and to examine the possible mechanisms. Forty two Sprague Dawley male rats were used and randomly distributed into 6 equal groups (n=7). The 1 st group was negative control and each rat from the other 5 groups was given a single subcutaneous dose (15 mg/kg b.wt.) of AOM once weekly for 2 weeks to induce colon cancer. The 2 nd group was kept positive control and rats in the 3 rd , 4 th , 5 th and 6 th groups were orally given RJ and AJ at low (5%) and high (10%) concentrations, respectively, daily for 12 weeks. Serum colon cancer biomarkers [(tumor necrosis factor α-(TNF-α); nuclear factor-κappaB (NF-κB); interleukin1β (IL-1β) and interleukin and 6 (IL6)] were measured and histopathology of the colon was done to evaluate the anticancer effect. Lipid peroxidation and activities of antioxidant enzymes in colon tissues and content of 8-hydroxy-2-deoxyguanosine (8-OHdG) (apoptosis marker) in colon DNA were measured to examine the possible mechanisms. The results showed that oral administration of RJ and AJ inhibited AOM-induced elevations in serum colon cancer biomarkers levels, antagonized preneoplastic abbrent colon crypts induced by AOM, decreased lipid peroxidation; increased activities of antioxidant enzymes in colon tissues and reduced elevation of 8-OHdG content in colon DNA. These results denoted that RJ and AJ have an anticancer effect against colon cancer. The mechanistic studies demonstrated that RJ and AJ inhibited lipid peroxidation, increased antioxidant enzyme activities (antagonized oxidative stress) and induced of apoptosis. It can be concluded that intake of black raspberry and apricot as fruit salad or juice may be beneficial for patients who suffer from colon cancer.

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Advanced Colorectal Cancer Is Associated With Enhanced IL-23 and IL-10 Serum Levels

Cited by 58 publications

References 29 publications

Cytokine Gene Polymorphisms in Colorectal Cancer

Cytokine Gene Polymorphisms in Colorectal Cancer

The paradox of IL-10-mediated modulation in cervical cancer

Anticancer Effect of Black Raspberry and Apricot Juice against Colon Cancer Induced by Azoxymethane in Male Rats

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