Advance on anti-diabetic effects of protein hydrolysates and peptides derived from cereals and pseudocereals

Abstract

Diabetes is a complex and heterogeneous disorder disease with elevated blood glucose, which is one of the most serious global public health problems. Cereals and pseudocereals, as staple food, are major sources of dietary protein. Cereal and pseudocereal proteins are potential sources of food-derived bioactive peptides and proposed to prevent and ameliorate diabetes. According to recent researches, this review summaries the isolation, purification and analysis of anti-diabetic protein hydrolysates and peptides from cereals and pseudocereals. In addition, their anti-diabetic activities and mechanisms were reviewed by in vitro inhibition of carbohydrate digestive enzyme and dipeptidyl peptidase-IV, in vivo hypoglycaemic effects, and glucose homeostasis in cell model.

Critical Review for the Production of Antidiabetic Peptides by a Bibliometric Approach

“…There is a lack of scientific evidence on the molecular mechanisms directly related to the regulation of glucose metabolism at the cellular level. Studies have reported that proteins and peptides can regulate glucose metabolism by inhibiting DPP-IV activity in Caco-2 cells, stimulating GLP-1 secretion in GLUTag cells, and promoting glucose uptake in insulin-resistant HepG2 cells [ 6 ].…”

“…Therefore, the development of natural food-derived peptide remedies may not only avoid the side effects, but also allow the early intervention and nutritional treatment of patients. Thus, they may be the ideal choice for preventing diabetes and improving its treatment [ 6 ]. To be effective, peptides need to be released from the protein matrix, be bioaccessible, and reach the active site in sufficient quantities to exhibit biological activity.…”

Glycaemic response of pseudocereal‐based gluten‐free food products: a review

“…Wu et al . (2020) reviewed that the protein hydrolysates and peptides derived from buckwheat and quinoa had significant antidiabetic effects in vitro retardation of digestive enzyme for carbohydrates and DPP‐IV, in vivo hypoglycaemic effects and glucose homeostasis in cell model, as compared to other cereals.…”

“…Components like bioactive peptides and hydrolysates also inhibit digestive enzymes and dipeptidyl peptidases IV (DPP-IV), which reduces blood glucose levels and provides antidiabetic effects in human beings (Thakur et al, 2021). Wu et al (2020) reviewed that the protein hydrolysates and peptides derived from buckwheat and quinoa had significant antidiabetic effects in vitro retardation of digestive enzyme for carbohydrates and DPP-IV, in vivo hypoglycaemic effects and glucose homeostasis in cell model, as compared to other cereals.…”