Adult Primitive Neuroectodermal Tumor: Proton MR Spectroscopic Findings with Possible Application for Differential Diagnosis

Majós, Carles; Alonso, Juli; Aguilera, Carles; Serrallonga, Marta; Acebes, J.J.; Arús, Carles; Gili, Jaume

doi:10.1148/radiol.2252011592

Cited by 99 publications

(52 citation statements)

References 36 publications

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“…45 Elevated Glx has also been observed on in vitro 1 H-MR spectroscopy studies of perchloric acid extracts of GBM specimens. 46,47 In our study, we observed significantly high Glx G/WM from the "hyperperfused" regions of the high-grade gliomas compared with the low-grade gliomas.…”

Section: Discussionmentioning

confidence: 94%

Arterial Spin-Labeling and MR Spectroscopy in the Differentiation of Gliomas

Chawla¹,

Wang²,

Wolf³

et al. 2007

American Journal of Neuroradiology

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Section: Discussionmentioning

confidence: 94%

Arterial Spin-Labeling and MR Spectroscopy in the Differentiation of Gliomas

Chawla¹,

Wang²,

Wolf³

et al. 2007

American Journal of Neuroradiology

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“…ficity. Previous studies have classified brain tumor grade with magnetic resonance spectroscopic biomarkers and pattern recognition algorithms (62)(63)(64)(65)(66)(67)(68). To this end, Preul et al (6) reported 99% accuracy with a linear discriminant analysis and values based on six metabolites, whereas Arle et al (69) reported 95% accuracy with neuronal networks algorithms on data combining magnetic resonance spectroscopic and clinical markers.…”

Section: Discussionmentioning

confidence: 99%

Noninvasive Magnetic Resonance Spectroscopic Imaging Biomarkers to Predict the Clinical Grade of Pediatric Brain Tumors

Astrakas

Zurakowski

Tzika

et al. 2004

Clinical Cancer Research

101

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The diagnosis and therapy of childhood brain tumors, most of which are low grade, can be complicated because of their frequent adjacent location to crucial structures, which limits diagnostic biopsy. Also, although new prognostic biomarkers identified by molecular analysis or DNA microarray gene profiling are promising, they too depend on invasive biopsy. Here, we test the hypothesis that combining information from biologically important intracellular molecules (biomarkers), noninvasively obtained by proton magnetic resonance spectroscopic imaging, will increase the diagnostic accuracy in determining the clinical grade of pediatric brain tumors. We evaluate the proton magnetic resonance spectroscopic imaging exams for 66 children with brain tumors. The intracellular biomarkers for choline-containing compounds (Cho), N-acetylaspartate, total creatine, and lipids and/or lactate were measured at the highest Cho region and normalized to the surrounding healthy tissue total creatine. Neuropathological grading was done with WHO criteria. Normalized Cho and lipids and/or lactate were elevated in high-grade (n ‫؍‬ 23) versus low-grade (n ‫؍‬ 43) tumors, which multiple logistic regression confirmed are independent predictors of tumor grade (for Cho, odds ratio 24.8, P < 0.001; and for lipids and/or lactate, odds ratio 4.4, P < 0.001). A linear combination of normalized Cho and lipids and/or lactate that maximizes diagnostic accuracy was calculated by maximizing the area under the receiver operating characteristic curve. Proton magnetic resonance spectroscopic imaging, although not a proxy for histology, provides noninvasive, in vivo biomarkers for predicting clinical grades of pediatric brain tumors.

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“…The Fourier transformation of the acquired signal provides a defined spectrum that allows for discrimination between various metabolites. Several studies have reported a reduction in the signal intensity of creatine and Nacetylaspartate and an increased level of the choline signal in brain tumors (89)(90)(91)(92)(93)(94). The amount of tumor infiltration is proportional to the decrease in N-acetylaspartate and the increase in choline signal (95,96).…”

Section: Beyond Anatomic Mri-toward Functional Imagingmentioning

confidence: 99%

Latest Advances in Molecular Imaging Instrumentation

Pichler¹,

Wehrl²,

Judenhofer³

2008

J Nucl Med

193

110

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This review concentrates on the latest advances in molecular imaging technology, including PET, MRI, and optical imaging. In PET, significant improvements in tumor detection and image resolution have been achieved by introducing new scintillation materials, iterative image reconstruction, and correction methods. These advances enabled the first clinical scanners capable of time-of-flight detection and incorporating point-spread-function reconstruction to compensate for depth-of-interaction effects. In the field of MRI, the most important developments in recent years have mainly been MRI systems with higher field strengths and improved radiofrequency coil technology. Hyperpolarized imaging, functional MRI, and MR spectroscopy provide molecular information in vivo. A special focus of this review article is multimodality imaging and, in particular, the emerging field of combined PET/MRI. PETi s a high-performance imaging technology that can image the whole-body distribution of positron-emitting biomarkers with high sensitivity. The invention of PET dates back more than 30 y. However, the acceptance of PET as a routine clinical diagnostic tool has been hampered by the need for an on-site cyclotron and a radiochemistry unit for the production of the short-lived radiotracers (1-7). With the availability of commercial radiopharmacies that supply PET probes and with the relatively broad insurance coverage for a variety of clinical indications, the number of PET centers now totals more than 2,000 worldwide.Major technologic milestones in the development of PET include the discovery of faster and brighter scintillators such as lutetium oxyorthosilicate (LSO), gadolinium oxyorthosilicate, and lutetium yttrium oxyorthosilicate. Furthermore, the continuing development of the detectors, progressing from one-to-one scintillator-to-photomultiplier-tube (PMT) coupling (8,9) to advanced block and Anger readout schemes, helps to limit the costs of a PET scanner by providing a multiplexed readout and reduced electronic channels (10-13).The use of faster scintillators enabled the transition from 2-dimensional data acquisitions for whole-body PET, using lead or tungsten collimators as septa (14-16), to 3-dimensional (3D) acquisitions (17). However, approximately an 8-fold increase in detection sensitivity is accompanied by an increased fraction of random and scattered photon events leading to degradation of image quality if not corrected during image reconstruction (18). This degradation effectively reduces the increase in sensitivity from a factor of 8 to approximately 5-fold. To achieve high-quality and quantitative PET data, various image reconstruction techniques have evolved (19). One simple approach is filtered backprojection, which is computationally fast but results in poor image quality if the count statistics of the available PET data are inadequate. Better image quality and improved spatial resolution are achieved by iterative methods such as ordered-subset expectation maximization or maximumlikelihood expectation maximiza...

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Adult Primitive Neuroectodermal Tumor: Proton MR Spectroscopic Findings with Possible Application for Differential Diagnosis

Abstract: In vivo proton MR spectroscopy provides useful information in clinical differentiation between PNETs and common brain tumors in adults.

Cited by 99 publications

References 36 publications

Arterial Spin-Labeling and MR Spectroscopy in the Differentiation of Gliomas

Arterial Spin-Labeling and MR Spectroscopy in the Differentiation of Gliomas

Noninvasive Magnetic Resonance Spectroscopic Imaging Biomarkers to Predict the Clinical Grade of Pediatric Brain Tumors

Latest Advances in Molecular Imaging Instrumentation

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