Adult height after spontaneous pubertal growth or GnRH analog treatment in girls with early puberty: a meta-analysis

Bertelloni, Silvano; Massart, Francesco; Miccoli, Mario; Baroncelli, Giampiero I.

doi:10.1007/s00431-017-2898-8

Cited by 27 publications

(19 citation statements)

References 31 publications

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“…For girls with ICPP, the GnRHa and rhGH combination therapy can improve FAH by a mean of 2.81 cm over GnRHa alone as reported by Liu et al [31]. Bertelloni et al indicated that GnRHa treatment does not significantly change the growth outcome in girls with EP [32]. It is believed that the use of the combined therapy for precocious puberty and early puberty is capable of resulting in a greater FAH, and indeed the findings of the present analysis are not ideal.…”

Section: Discussionmentioning

confidence: 94%

Is a Combination of a GnRH Agonist and Recombinant Growth Hormone an Effective Treatment to Increase the Final Adult Height of Girls with Precocious or Early Puberty?

Song

Zhao

Liang

et al. 2018

International Journal of Endocrinology

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The aim of treatment for idiopathic central precocious puberty (ICPP) is to increase final adult stature, for which gonadotropin-releasing hormone agonist (GnRHa) is the gold standard. Early puberty is frequently similar to ICPP, with pubertal onset only slightly advanced. Short stature may result from early pubertal onset. Some studies have suggested that recombinant human growth hormone (rhGH) should be combined with a GnRHa to improve adult height, while others have not. Here, the aim was to compare the efficacy of combined GnRHa and rhGH treatment with GnRHa or rhGH treatment alone, or no therapy, for the improvement of the final height of girls with ICPP or early puberty. Electronic databases of randomized and quasi-randomized controlled trials, in which the efficacy of GnRHa preparations was compared with that of rhGH for the treatment of children with precocious or early puberty, were searched and a meta-analysis conducted. Five studies of early puberty and four studies of ICPP were identified. There were no statistically significant differences between final adult height standard deviation score and initial height standard deviation score in the treatment of early puberty (GnRHa and rhGH versus rhGH alone or no treatment). The overall analysis of the data failed to indicate any benefit of combined therapy, while individual reports suggested that in specific instances combined therapy may be beneficial in preserving or reclaiming growth potential and improving adult height.

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Section: Discussionmentioning

confidence: 94%

Is a Combination of a GnRH Agonist and Recombinant Growth Hormone an Effective Treatment to Increase the Final Adult Height of Girls with Precocious or Early Puberty?

Song

Zhao

Liang

et al. 2018

International Journal of Endocrinology

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“…This corresponds to a mean age of 11.9 years at menarche, which is only slightly earlier than that of a population cohort (12.3 years) 2427. Similarly, systematic review evidence suggests that children with precocious puberty who do not receive GnRH attain a similar height to those who are treated 28…”

Section: How Is It Managed?mentioning

confidence: 89%

Precocious puberty

Bradley

Lawrence

Steele

et al. 2020

BMJ

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“…Meta‐analyses may have been missed by our search strategy for this particular analysis (which was not a systematic review). A positive note is that meta‐analyses on puberty are continually being published (e.g., Bertelloni, Massart, Miccoli, & Baroncelli, ; Deng et al., ; Durand, Tauber, Patel, & Dutailly, ; Li et al., ; Ullsperger & Nikolas, ). Given the breadth and quantity of research on puberty, meta‐analyses will continue to be particularly useful for synthesizing the literature on puberty in the future.…”

Section: Discussionmentioning

confidence: 99%

Puberty in the Last 25 Years: A Retrospective Bibliometric Analysis

Marceau

Hottle

Yatcilla

2019

J of Research on Adolesc

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Puberty research has been highly productive in the past few decades and is gaining momentum. We conducted an analysis of bibliographic data, including titles, abstracts, keywords, indexing terms, and citation data to assess the sheer numbers, audience and reach, publication types, and impact of puberty-related publications. Findings suggest that puberty-related publications are increasing in sheer numbers, and have reach in many fields as befits an interdisciplinary science. Puberty-related publications typically have higher impact in terms of citations than the journal averages, among the journals that published the most studies on puberty. Limitations of the field and recommendations for researchers to improve the impact and reach of puberty-related publications (e.g., clear conclusions in abstracts, highlighting the importance of puberty) are discussed.

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Adult height after spontaneous pubertal growth or GnRH analog treatment in girls with early puberty: a meta-analysis

Cited by 27 publications

References 31 publications

Is a Combination of a GnRH Agonist and Recombinant Growth Hormone an Effective Treatment to Increase the Final Adult Height of Girls with Precocious or Early Puberty?

Is a Combination of a GnRH Agonist and Recombinant Growth Hormone an Effective Treatment to Increase the Final Adult Height of Girls with Precocious or Early Puberty?

Precocious puberty

Puberty in the Last 25 Years: A Retrospective Bibliometric Analysis

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