Precocious puberty

Bradley, Stephen H; Lawrence, Neil D.; Steele, Caroline; Mohamed, Zainaba

doi:10.1136/bmj.l6597

Cited by 71 publications

(75 citation statements)

References 28 publications

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“…However, several biological and environmental factors can interfere with the neuromuscular quality of skills that require the use of motor coordination and muscle strength [3][4][5]. At the biological level, we can highlight the puberty process, which is the triggering of improvements in neurological, muscular, skeletal, and endocrine systems [6]. Among the environmental factors, we can highlight the level of physical activity, nutrition and quality of sleep, which are extremely important for the quality of the biological maturation process [7,8].…”

Section: Introductionmentioning

confidence: 99%

“…Sex hormones, such as estradiol, testosterone, and growth hormone, have extremely important functions in human biological development, which can mainly affect morphological structure, skeletal growth, and muscle strength levels [9][10][11][12][13][14][15][16][17]. In this context, among neuromuscular parameters, muscle strength and body speed are two of the most essential for body functionality in relation to physical health, and for the development of specific skills related to sports performance [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

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Can the Neuromuscular Performance of Young Athletes Be Influenced by Hormone Levels and Different Stages of Puberty?

Almeida-Neto

Matos

Pinto

et al. 2020

IJERPH

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Background: Endocrine mechanisms can be a determining factor in the neuromuscular performance of young athletes. Objective: The objective of the present study was to relate maturational and hormonal markers to neuromuscular performance, as well as to verify whether young athletes with different testosterone levels show differences in muscle strength. Methods: The sample consisted of 37 young male Brazilian athletes (11.3 ± 0.94 years) who were members of a sports initiation project. Hormonal markers were analyzed biochemically by blood samples, and maturation markers by mathematical models based on anthropometry. Body composition was verified by tetrapolar bioimpedance. The performance of upper and lower limb strength and body speed were analyzed. Results: Hormonal and maturational markers were related to neuromuscular performance (p < 0.05). Young people with higher testosterone levels showed higher muscle strength (p < 0.05). Artificial neural networks showed that testosterone predicted the performance of upper limbs by 49%, and maturation by 60%. Maturation foreshadowed the performance of lower limbs by 30.3%. Conclusion: Biological maturation and hormonal levels can be related to neuromuscular performance, and young people with higher testosterone levels show superior muscle strength in relation to the others.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Can the Neuromuscular Performance of Young Athletes Be Influenced by Hormone Levels and Different Stages of Puberty?

Almeida-Neto

Matos

Pinto

et al. 2020

IJERPH

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“…Precocious puberty (PP) is one of the most common endocrine diseases in children. PP is commonly defined as puberty that starts before age eight in Chinese girls and age nine in Chinese boys (Bradley et al, 2020), before age 7.5 in African-American and Hispanic girls, and before age eight in Caucasian girls (Herman-Giddens, 2006). The age of pubertal onset based on thelarche has decreased by almost 3 months per decade from 1977 to 2013 (Eckert-Lind et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

“…The incidence of CPP in China is approximately 1% (Luan et al, 2007). The male to female ratio of patients with PP is approximately 1:5-10 (Teilmann et al, 2005;Dong et al, 2020), and 74% of the cases in girls with CPP are idiopathic (Bradley et al, 2020;Tao et al, 2020). Although the incidence of PP in boys is low, the disorder may be caused by certain serious diseases and should be given attention (Kaplowitz and Bloch, 2016).…”

Section: Introductionmentioning

confidence: 99%

The Traditional Chinese Medicine Fuyou Formula Alleviates Precocious Puberty by Inhibiting GPR54/GnRH in the Hypothalamus

Bai

Huan

et al. 2021

Front. Pharmacol.

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The purpose of this study was to explore the effect of the traditional Chinese medicine Fuyou formula on precocious puberty (PP). The Fy formula may exert an effect in female rats with PP and GT-7 cells through the GPR54/GnRH signaling pathway. To confirm the effect of the Fy formula on PP through the GPR54/GnRH signaling pathway, we first treated GT1-7 cells with the Fy formula and observed changes in the expression of related genes and proteins and in GnRH secretion. Then, we randomly divided young female Sprague-Dawley rats into the control group, model group, leuprorelin group and the Fy formula group. A PP model was established by injection of danazol on postnatal day 5, and the Fy formula was administered on PND15. The time of vaginal opening, the wet weights of the ovary and uterus, serum hormone levels and the expression of hypothalamic-related genes were observed. We found that the Fy formula delayed vaginal opening, decreased the wet weights and coefficients of the ovary and uterus, decreased the levels of serum hormones (E2, follicle-stimulating hormone and luteinizing hormone) and the cellular GnRH level, and downregulated the gene expression of Kiss1, GPR54 and GnRH in the hypothalamus and the gene and protein expression of GPR54 and GnRH in GT1-7 cells. In conclusion, the Fy formula may alleviate PP via the GPR54/GnRH signaling pathway.

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“…Central precocious puberty (CPP) is characterized by early hypothalamic-pituitarygonadal axis activation. When girls and boys show signs of puberty and its progression before the ages of 8 and 9, respectively, it is considered precocious puberty [6]. Clinically, patients with CPP experience growth spurts, rises in pubertal hormones, and bone age advancements.…”

Section: Introductionmentioning

confidence: 99%

Myopic Progression in Girls with Gonadotrophin-Releasing Hormone Agonist Treatment for Central Precocious Puberty

et al. 2021

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We sought to determine whether the myopic progression of patients with central precocious puberty (CPP) who were undergoing treatment differed from that of their healthy peers with normal pubertal onset and progression. Eighteen girls with CPP and 14 age-matched controls who underwent regular ophthalmic examinations for at least 1 year were included. All the CPP patients received a 3.75 mg leuprolide acetate depot subcutaneously every 28 days. The spherical equivalent (SE) and axial length (AL) for myopia progression and the pubertal parameters (height, body weight, body mass index, Tanner stage, and bone age) were compared between the two groups. Of 32 subjects with a mean age of 8.6 ± 0.7 years, the SEs and ALs did not differ at baseline between the two groups, which had similar weight and similar body mass index. After 1 year, both the CPP patients and controls showed myopic progression, with an average myopic shift of −0.73 ± 0.48 diopters (D) and AL elongation with a mean change of 0.44 ± 0.61 mm. The SE and AL changes over 1 year were greater in the controls than those in the CPP patients, which was not statistically significant (–0.85 ± 0.55 D vs. –0.64 ± 0.41 D and 0.55 ± 0.89 mm vs. 0.35 ± 0.22 mm, respectively). The change in AL correlated significantly with the change in the height (β = 0.691, p = 0.039). In this 1-year study, the CPP patients with treatments trended to show less myopic progression than the controls.

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Precocious puberty

Cited by 71 publications

References 28 publications

Can the Neuromuscular Performance of Young Athletes Be Influenced by Hormone Levels and Different Stages of Puberty?

Can the Neuromuscular Performance of Young Athletes Be Influenced by Hormone Levels and Different Stages of Puberty?

The Traditional Chinese Medicine Fuyou Formula Alleviates Precocious Puberty by Inhibiting GPR54/GnRH in the Hypothalamus

Myopic Progression in Girls with Gonadotrophin-Releasing Hormone Agonist Treatment for Central Precocious Puberty

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