Adult granulosa cell tumor associated with endometrial carcinoma: a case report

Abstract

IntroductionIf strict criteria for the diagnosis of carcinoma are used and all patients with granulosa cell tumors are considered, the best estimate of the incidence of associated endometrial carcinomas is under 5%. In patients with granulosa cell tumors, estrogen-dependent endometrial cancers are rarely found, and most of these endometrial cancers are well-differentiated endometrioid adenocarcinomas that carry a good prognosis when detected early.Case presentationWe report the case of a 65-year-old post-menopausal Nigerian woman of the Igbo tribe with an adult granulosa cell tumor that was initially treated as endometrial carcinoma. She underwent a total abdominal hysterectomy and a bilateral salpingo-oophorectomy after histopathologic confirmation of a well-differentiated granulosa cell tumor of the ovary and a nuclear grade 1 adenocarcinoma of the endometrium (International Federation of Obstetricians and Gynecologists stage 1B). She had a good post-operative recovery and was discharged 10 days after treatment.ConclusionThe association between adult granulosa cell tumors of the ovary and endometrial carcinomas is rare. A high index of suspicion as well as good imaging and histopathologic analyses are important in making this diagnosis.

Adult-type ovarian granulosa cell tumour: Treatment Outcomes from a Single Institutional Experience

“…This is of utmost importance, as it may lead to endometrial abnormalities with an incidence of 30-85% endometrial hyperplasia and 3-20% endometrial carcinoma. (9,23,24) In our study hyperplasia was documented in 26% of all group with no endometrial carcinoma found, which matches the international results.…”

A Case of Granulosa Cell Tumour with Atypical Presentation

“…Adult variety is common accounts to 95%. [4] Generally the adult variety occurs in peri [40-45years] and post menopausal women with peak incidence at 50-55 years. The Juvenile one occurs in pre-pubertal age group.…”

A Cystic Granulosa Cell Tumor of Ovary: An Incidental Finding in a 50 years Old Lady

“…Adult granulosa cell tumour (GCT) is a rare ovarian malignancy accounting for 1-2% of all tumours and 95% of germ cell tumours originating from sex cord-stromal cells. [1] .GCT can occur at any age but most commonly presents during the peri-menopausal or early postmenopausal period with median age of diagnosis between 50 and 54 years in most cases. [2] It is the most common hormoneproducing ovarian tumour which, usually produce oestrogen and leads to symptoms and signs of oestrogen excess.…”