Adult Glioma Incidence and Survival by Race or Ethnicity in the United States From 2000 to 2014

Ostrom, Quinn T.; Coté, David J.; Ascha, Mustafa; Kruchko, Carol; Barnholtz‐Sloan, Jill S.

doi:10.1001/jamaoncol.2018.1789

Cited by 408 publications

(320 citation statements)

References 44 publications

(96 reference statements)

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“…For example, in the current study, we identified an 18% increased incidence of glioma in high SES counties compared with low SES counties. 7,14,37 The preclinical period for these tumors is likely short and they are rapidly progressive, with distinctive symptoms that prompt medical care. 14,33,34 For some cancers of other sites, differential rates of incidence by SES can be attributed to ascertainment bias.…”

Section: Incidence Of Glioma By Sesmentioning

confidence: 99%

“…37 A prior study identified an increased risk of brain cancer among individuals living in a metropolitan county. This suggests that the overall findings of a higher incidence in high SES areas are driven mainly by differential rates among white non-Hispanic individuals and, to a lesser extent, white Hispanic individuals, rather than other racial and ethnic groups.…”

Section: Incidence Of Glioma By Sesmentioning

confidence: 99%

“…5,35,37 In addition, living in an area of high SES is associated with improved all-cause mortality, due to a variety of factors, including fewer environmental exposures, that increase the risk of death. High SES is associated with better access to health care, including access to surgery, radiation, chemotherapy, and other adjunctive treatments, all of which have been shown to improve survival after diagnosis.…”

Section: Survival By Ses After a Diagnosis Of Gliomamentioning

confidence: 99%

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Glioma incidence and survival variations by county‐level socioeconomic measures

Coté

Ostrom

Gittleman

et al. 2019

Cancer

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BACKGROUND: Multiple studies have reported higher rates of glioma in areas with higher socioeconomic status (SES) but to the authors' knowledge have not stratified by other factors, including race/ethnicity or urban versus rural location. METHODS: The authors identified the average annual age-adjusted incidence rates and calculated hazard ratios for death for gliomas of various subtypes, stratified by a county-level index for SES, race/ethnicity, US region, and rural versus urban status. RESULTS: Rates of glioma were highest in counties with higher SES (rate ratio, 1.18; 95% CI, 1.15-1.22 comparing the highest with the lowest quintiles [P < .001]). Stratified by race/ethnicity, higher rates in high SES counties persisted for white non-Hispanic individuals. Stratified by rural versus urban status, differences in incidence by SES were more pronounced among urban counties. Survival was higher for residents of high SES counties after adjustment for age and extent of surgical resection (hazard ratio, 0.82; 95% CI, 0.76-0.87 comparing the highest with the lowest quintile of SES [P < .001]). Survival was higher among white Hispanic, black, and Asian/Pacific Islander individuals compared with white non-Hispanic individuals, after adjustment for age, SES, and extent of surgical resection, and when restricted to those individuals with glioblastoma who received radiation and chemotherapy. CONCLUSIONS: The incidence of glioma was higher in US counties of high compared with low SES. These differences were most pronounced among white non-Hispanic individuals and white Hispanic individuals residing in urban areas. Better survival was observed in high SES counties, even when adjusting for extent of surgical resection, and when restricted to those who received radiation and chemotherapy for glioblastoma. Differences in incidence and survival were associated with SES and race, rather than rural versus urban status. Cancer 2019;125:3390-3400.

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Section: Incidence Of Glioma By Sesmentioning

confidence: 99%

Section: Incidence Of Glioma By Sesmentioning

confidence: 99%

Section: Survival By Ses After a Diagnosis Of Gliomamentioning

confidence: 99%

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Glioma incidence and survival variations by county‐level socioeconomic measures

Coté

Ostrom

Gittleman

et al. 2019

Cancer

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“…Glioma incidence is highest in countries with majority European ancestry (EA) populations, including northern Europe, the US and Canada . Within the US, incidence of these tumors is highest among non‐Hispanic Whites …”

Section: Introductionmentioning

confidence: 99%

“…2 Within the US, incidence of these tumors is highest among non-Hispanic Whites. 1,3 Though these tumors are rare, they cause significant morbidity and mortality. There are few confirmed risk factors, and the vast majority of cases occur in individuals with no family history.…”

Section: Introductionmentioning

confidence: 99%

Glioma risk associated with extent of estimated European genetic ancestry in African Americans and Hispanics

Ostrom

Egan

Nabors

et al. 2019

Intl Journal of Cancer

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Glioma incidence is highest in non‐Hispanic Whites, and to date, glioma genome‐wide association studies (GWAS) to date have only included European ancestry (EA) populations. African Americans and Hispanics in the US have varying proportions of EA, African (AA) and Native American ancestries (NAA). It is unknown if identified GWAS loci or increased EA is associated with increased glioma risk. We assessed whether EA was associated with glioma in African Americans and Hispanics. Data were obtained for 832 cases and 675 controls from the Glioma International Case–Control Study and GliomaSE Case–Control Study previously estimated to have <80% EA, or self‐identify as non‐White. We estimated global and local ancestry using fastStructure and RFMix, respectively, using 1,000 genomes project reference populations. Within groups with ≥40% AA (AFR≥0.4), and ≥15% NAA (AMR≥0.15), genome‐wide association between local EA and glioma was evaluated using logistic regression conditioned on global EA for all gliomas. We identified two regions (7q21.11, p = 6.36 × 10−4; 11p11.12, p = 7.0 × 10−4) associated with increased EA, and one associated with decreased EA (20p12.13, p = 0.0026) in AFR≥0.4. In addition, we identified a peak at rs1620291 (p = 4.36 × 10−6) in 7q21.3. Among AMR≥0.15, we found an association between increased EA in one region (12q24.21, p = 8.38 × 10−4), and decreased EA in two regions (8q24.21, p = 0. 0010; 20q13.33, p = 6.36 × 10−4). No other significant associations were identified. This analysis identified an association between glioma and two regions previously identified in EA populations (8q24.21, 20q13.33) and four novel regions (7q21.11, 11p11.12, 12q24.21 and 20p12.13). The identifications of novel association with EA suggest regions to target for future genetic association studies.

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Neural Regulation of Cancer: Cancer‐Induced Remodeling of the Central Nervous System

Krishna

Hervey-Jumper

2022

Advanced Biology

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In recent years, there have been significant advances in understanding the neuronal influence on the biology of solid tumors such as prostate, pancreatic, gastric, and brain cancers. An increasing amount of experimental evidence across multiple tumor types strongly suggests the existence of bidirectional crosstalk between cancer cells and the neural microenvironment. However, unlike cancers affecting many solid organs, brain tumors, namely gliomas, can synaptically integrate into neural circuits and thus can exert a greater potential to induce dynamic remodeling of functional circuits resulting in long‐lasting behavioral changes. The first part of the review describes dynamic changes in language, sensory, and motor networks following glioma development and presents evidence focused on how different patterns of glioma‐induced cortical reorganization may predict the degree and time course of functional recovery in brain tumor patients. The second part focuses on the network and cellular‐level mechanisms underlying glioma‐induced cerebral reorganization. Finally, oncological and clinical factors influencing glioma‐induced network remodeling in glioma patients are reviewed.

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Adult Glioma Incidence and Survival by Race or Ethnicity in the United States From 2000 to 2014

Cited by 408 publications

References 44 publications

Glioma incidence and survival variations by county‐level socioeconomic measures

Glioma incidence and survival variations by county‐level socioeconomic measures

Glioma risk associated with extent of estimated European genetic ancestry in African Americans and Hispanics

Neural Regulation of Cancer: Cancer‐Induced Remodeling of the Central Nervous System

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