2019
DOI: 10.1002/ijc.32318
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Glioma risk associated with extent of estimated European genetic ancestry in African Americans and Hispanics

Abstract: Glioma incidence is highest in non‐Hispanic Whites, and to date, glioma genome‐wide association studies (GWAS) to date have only included European ancestry (EA) populations. African Americans and Hispanics in the US have varying proportions of EA, African (AA) and Native American ancestries (NAA). It is unknown if identified GWAS loci or increased EA is associated with increased glioma risk. We assessed whether EA was associated with glioma in African Americans and Hispanics. Data were obtained for 832 cases a… Show more

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Cited by 23 publications
(11 citation statements)
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“…The root of this disparity may be partly attributed to the variance of hereditary susceptibility between races. A genome-wide association study suggested that increased European ancestry in non-European population might be associated with the occurrence of glioma and identified four novel susceptibility variants, including 7q21.11 (SEMA3A), 11p11.12 (Intergenic), 12q24.21 (RBM19) and 20p12.13 (HAO1, BMP2) [ 23 ]. Researchers have identified specific hereditary syndromes, such as Lynch and Li-Fraumeni, that are risk factors of glioma, although these diseases are rare [ 24 ].…”
Section: Discussionmentioning
confidence: 99%
“…The root of this disparity may be partly attributed to the variance of hereditary susceptibility between races. A genome-wide association study suggested that increased European ancestry in non-European population might be associated with the occurrence of glioma and identified four novel susceptibility variants, including 7q21.11 (SEMA3A), 11p11.12 (Intergenic), 12q24.21 (RBM19) and 20p12.13 (HAO1, BMP2) [ 23 ]. Researchers have identified specific hereditary syndromes, such as Lynch and Li-Fraumeni, that are risk factors of glioma, although these diseases are rare [ 24 ].…”
Section: Discussionmentioning
confidence: 99%
“… 13 , 28 , 30 , 31 Non-Hispanic White race/ethnicity has been associated with higher glioma incidence among adults, with 2 genomic regions related to European ancestry associated with increased adult glioma risk based on local admixture estimation. 32 , 33 This may also explain the observed association between higher percent of foreign-borns and lower glioma and medulloblastoma risk in Hispanics, as Hispanics that migrated more recently tend to have lower European ancestry based on global admixture estimation. 34 Therefore, common germline variants and haplotypes that are associated with increased adult glioma risk, of which some are related to European ancestry, may also be associated with increased pediatric glioma risk.…”
Section: Discussionmentioning
confidence: 99%
“…Five-year survival, following diagnosis and treatment of a primary malignant brain tumor is ~30%. Among pediatric brain tumors, high-grade gliomas (pHGGs), including diffuse intrinsic pontine gliomas (DIPGs), are especially devastating, with an average patient survival of less than 15 months (1). In the last decade, pHGGs have been extensively characterized and remarkable progress has been made at understanding mechanisms associated with the tumors at the molecular level.…”
Section: Introductionmentioning
confidence: 99%