Adult bone marrow–derived stem cells for organ regeneration and repair

Tögel, Florian; Westenfelder, Christof

doi:10.1002/dvdy.21258

Cited by 115 publications

(83 citation statements)

References 110 publications

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“…Recent reviews have summarized the effects of clinical trials in which satellite cells (SC, the stem cell of skeletal muscle) and bone marrow cells (BMC) were transplanted to ameliorate the effects of myocardial infarction (Togel and Westenfelder, 2007;Segers and Lee, 2008;Passier et al, 2008, for reviews). The results have been generally disappointing, with improvements in cardiac function ranging from nonexistent to modest.…”

Section: Regeneration Of Myocardiummentioning

confidence: 99%

Stretching the limits: Stem cells in regeneration science

Stocum

Zupanc

2008

Developmental Dynamics

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Section: Regeneration Of Myocardiummentioning

confidence: 99%

Stretching the limits: Stem cells in regeneration science

Stocum

Zupanc

2008

Developmental Dynamics

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“…This construct can either be delivered to and retained within the damaged site or CONTACT Mohsen Sheykhhasan m.sheykhhasan@acecr.ac.ir pre-cultured to generate the needed tissue which is later transplanted to the needed location. Thus, the choice of suitable cells and scaffolds is the major challenge in TE (Schnabel et al 2002;Tuan 2004;Tögel & Westenfelder 2007;Stocum & Zupanc 2008). The appropriate cells intended for cell therapy must have certain characteristics: they should be relatively easily available, safe, and demonstrate efficiency in the stimulation of reparation of different tissue.…”

Section: Introductionmentioning

confidence: 99%

The effects of synthetic and natural scaffolds on viability and proliferation of adipose-derived stem cells

Ghiasi

Kalhor

Qomi

et al. 2015

Frontiers in Life Science

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This study presents a comparative assessment of adipose-derived stem cell (ADSCs) proliferation rates and their viability on five different scaffolds. Five different biomaterial scaffolds were prepared: alginate, poly lactic-co-glycolic acid, fibrin glue, inactive platelet-rich plasma, and active plateletrich plasma (APRP). Stem cells were isolated from human adipose tissue. Flow cytometry analysis was performed. Specifically, adipogenesis/osteogenesis/chondrogenesis-associated genes expression was analyzed by real-time polymerase chain reaction. These cells were seeded in the prepared scaffolds. After 14 days, the proliferation and viability of MSCs were evaluated using an MTT assay. Also, stemness genes expression was analyzed with the reverse transcriptasepolymerase chain reaction (RT-PCR) method. In addition, the DNA content assay was also performed. The obtained results showed a significant difference between cell proliferation and viability of different scaffolds. APRP and alginate were shown to be the most and least suitable scaffolds in terms of enhancing cell proliferation and maintaining cell viability respectively (p < .05). RT-PCR reactions demonstrated the expression of the various stemness-related markers (Nanog, Octamer4A, and Sox2) when ADSC cells were grown separately on the five different scaffolds. Our study indicates that compared with the scaffolds, APRP could be the best scaffold for support of ADSC proliferation. ARTICLE HISTORY

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“…For example, MCSs have expression of CD73, CD90 and CD105, and absence of CD34 and CD45 (6). Thus, cardiomyogenic differentiation of BMSCs can be recognized by their specific cell surface marker.…”

Section: Methods For Differentiation Of Bmscs Into Cardiomyocytesmentioning

confidence: 99%

“…This method has been adopted for clinical purpose due to the easy availability of mobilized stem cells. The clinical trails have shown the realizable possibility and safety of mobilization (6).…”

Section: Use Of Bmscs For Myocardial Infarctionmentioning

confidence: 99%

Mesenchymal Stem Cells for Treatment of Myocardial Infarction

Ko¹,

Kim²

2008

Int J Stem Cells

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Cardiovascular diseases including myocardial infarction are one of the major causes of adult mortality. Several treatments such as pharmacological therapy and heart transplantation have been used for the diseases, but the treatments have drawbacks. Therefore, cell-based myocardial therapies have received proper medical attention. Bone marrow stem cell (BMSC) including mesenchymal stem cell (MSC) and hematopoietic stem cell (HSC) is a potential source for cell therapy for heart diseases due to the ability of BMSC to differentiate into cell in cardiac tissue including cardiomyocyte and vascular endothelial cell. This article reviews the use of BMSCs for cardiovascular disease and the differentiation of BMSCs into cardiaomyocytes.

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Adult bone marrow–derived stem cells for organ regeneration and repair

Cited by 115 publications

References 110 publications

Stretching the limits: Stem cells in regeneration science

Stretching the limits: Stem cells in regeneration science

The effects of synthetic and natural scaffolds on viability and proliferation of adipose-derived stem cells

Mesenchymal Stem Cells for Treatment of Myocardial Infarction

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