Adsorption and release studies of sodium ampicillin from hydroxyapatite and glass-reinforced hydroxyapatite composites

Queiroz, Ana Carolina; Santos, J. D.; Monteiro, Fernando J.; Gibson, Iain R.; Knowles, Jonathan C.

doi:10.1016/s0142-9612(00)00296-9

Cited by 95 publications

(49 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The XRD and FTIR analysis of Bonelike® confirm that this material is composed of three crystalline phases: a major phase of HA and two secondary phases of α-TCP and β-TCP, in accordance with the literature [33,48]. On the contrary, the XRD spectrum of Osteobiol® (Figure 6b) indicates a low-crystallinity material, in agreement with its constitution: a crystalline phase (carbonated hydroxyapatite) and an amorphous phase (collagen).…”

Section: Accepted M Manuscriptsupporting

confidence: 86%

Comparison of a xenogeneic and an alloplastic material used in dental implants in terms of physico-chemical characteristics and in vivo inflammatory response

Figueiredo

Coimbra

Cabrita

et al. 2013

Materials Science and Engineering: C

View full text Add to dashboard Cite

Two commercial bone grafts used in dentistry (Osteobiol Gen-Os®, a xenograft of porcine origin, and Bonelike®, a hydroxyapatite based synthetic material), in the form of granules, were characterized and evaluated in vivo regarding the intensity of the tissue inflammatory response. These biomaterials were characterized in terms of morphology, particle size distribution, porosity and pore size, specific surface are and density. The chemical composition and structure of the materials were accessed by Fourier-Transform Infrared Spectroscopy (FTIR) and X-ray Diffraction (XRD). The graft materials were implanted in the gluteus maximus muscles of Wistar rats and the inflammatory response evaluated through histological analysis, after one week of implantation.The results showed that the two grafts have quite different characteristics in practically all the evaluated properties. While Osteobiol® exhibits a structure and composition similar to the natural bone, Bonelike® is constituted by a main crystalline phase of hydroxyapatite and two secondary phases of -and -tricalcium phosphate. Osteobiol® granules, besides being larger, are irregular, and exhibit sharp-edged tips, while those of Bonelike® are approximately cylindrical, with round contours, and more uniform in size. The in vivo response evaluated from the inflammatory infiltrates revealed that although both implants did not cause severe inflammation, Bonelike® granules elicit a consistently more intense inflammatory reaction than that triggered by the granules of Osteobiol®, particularly in terms of collagen production and formation of fibrous capsule. This reaction was partly explained in terms of the characteristics evaluated for the granules of this material.

show abstract

Section: Accepted M Manuscriptsupporting

confidence: 86%

Comparison of a xenogeneic and an alloplastic material used in dental implants in terms of physico-chemical characteristics and in vivo inflammatory response

Figueiredo

Coimbra

Cabrita

et al. 2013

Materials Science and Engineering: C

View full text Add to dashboard Cite

show abstract

“…Above this concentration the amount of sodium ampicillin adsorbed was the same for all the solutions used (up to 20 mg/ml), proving that for the 10 mg/ml solution all the potential material adsorption sites had been occupied and, consequently 10 mg/ml was the highest solution concentration used in these tests. It was also noticed that HA adsorbed more than GR-HA and that, for the GR-HA, the higher the amount of glass present, the higher was the adsorption, as previously discussed [16].…”

Section: Adsorption Resultssupporting

confidence: 69%

“…A calibration curve was made and adjusted to Beer-Lambert law with a correlation factor of 0.9998, with a range of sodium ampicillin concentrations from 0 to 0.1 mg/ml [16]. As for metronidazole, three samples were used for each concentration.…”

Section: Adsorbed Antibiotic Measurementsmentioning

confidence: 99%

See 1 more Smart Citation

Development of a system to adsorb drugs onto calcium phosphate materials

Queiroz

Santos

Monteiro

2005

J Mater Sci: Mater Med

View full text Add to dashboard Cite

Several studies were carried out in order to reduce the systemic use of antibiotics due to the high concentration required to provide the minimum inhibitory concentration (MIC) at infected sites. The aim of this study was to develop a system of drug adsorption onto commercial hydroxyapatite (HA, Ca 10 (PO 4 ) 6 (OH) 2 ) and glass reinforced hydroxyapatite (GR-HA) granules. The drug will then be released for the local treatment of periodontitis. The antibiotics used in this study were metronidazole, a specific antibiotic indicated for the systemic treatment of periodontitis, and ampicillin, a wide spectrum antibiotic. UV spectroscopy was used to measure the amount of drug adsorbed onto HA and GR-HA granules. Results showed that metronidazole was unable to adsorb on the material's surface, as opposed to ampicillin which adsorbed both onto HA and GR-HA. Preliminary release kinetics studies were carried out using a flow through dissolution system. Results are discussed in terms of the influence of the different surface characteristics of the materials on the adsorption processes. C 2005 Springer Science + Business Media, Inc.

show abstract

“…In contrast, the microcompressive strength of individual HApS particles is only about 0.6 MPa, which is extremely low compared to the value of approximately 180 MPa for fluoroaluminosilicate glass particles 20) . In addition, HAp also has the ability to not only adsorb but also release several substances 29,30) . Shiozawa et al 31) demonstrated that Ca enhanced the formation of GIC matrix, as a results, the surface hardness of GIC increased.…”

Section: Discussionmentioning

confidence: 99%

Effects of porous-hydroxyapatite incorporated into glass-ionomer sealants

et al. 2015

View full text Add to dashboard Cite

The purpose of the present study was to evaluate the mechanical and chemical properties of a novel glass ionomer cement for use as a pit and fissure sealant containing a porous hydroxyapatite, namely, apatite ionomer cement (AIC). Control sealant samples were used Fuji III (GIC-S). The experiment sealant samples (AIC-S) consisted of porous spherical hydroxyapatite (HApS) particles added at 28 wt% to GIC-S powder. The GIC-S and AIC-S samples were evaluated through mechanical strength measurements, scanning electron microscopy observations, energy dispersive X-ray spectroscopy analysis, fluoride ion release tests, and antibacterial tests. The flexural strength of the AIC-S was significantly higher than that of GIC-S for each period, 1 h, 24 h and 1 year. The fluoride release dose for AIC-S was consistently higher than that for GIC-S. In addition, the antibacterial properties of AIC-S were superior to those of GIC-S. The novel AIC-S may be a more suitable sealant material for pits and fissures with intact and/or infected enamel.

show abstract

Adsorption and release studies of sodium ampicillin from hydroxyapatite and glass-reinforced hydroxyapatite composites

Cited by 95 publications

References 22 publications

Comparison of a xenogeneic and an alloplastic material used in dental implants in terms of physico-chemical characteristics and in vivo inflammatory response

Comparison of a xenogeneic and an alloplastic material used in dental implants in terms of physico-chemical characteristics and in vivo inflammatory response

Development of a system to adsorb drugs onto calcium phosphate materials

Effects of porous-hydroxyapatite incorporated into glass-ionomer sealants

Contact Info

Product

Resources

About