Development of a system to adsorb drugs onto calcium phosphate materials

Queiroz, Ana Carolina; Santos, J. D.; Monteiro, Fernando J.

doi:10.1007/s10856-005-2535-3

Cited by 21 publications

(13 citation statements)

References 16 publications

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“…The release kinetics of erythromycin from the microspheres was different from that of amoxicillin and amoxicillin + clavulanic acid (being the releasing profile of the former two very similar). Erythromycin presented a more effective sustained release, presenting a very high release concentration till 432 h. In accordance with other authors,12, 13, 16 this fact can be explained by differences in the chemical structure between antibiotics, giving rise to different chemical binding (adsorption) between antibiotics and the materials.…”

Section: Discussionsupporting

confidence: 87%

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Nanohydroxyapatite microspheres as delivery system for antibiotics: Release kinetics, antimicrobial activity, and interaction with osteoblasts

Ferraz

Pataquiva-Mateus

Sousa

et al. 2007

J Biomedical Materials Res

124

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Severe periodontitis treatment, where massive alveolar bone loss occurs, involves bone defect filling and intensive systemic log-term antibiotics administration. This study aims at developing novel injectable drug delivery systems (nanohydroxyapatite microspheres) with the drug releasing capability for periodontitis treatment and simultaneously initiating the osteointegration process. Materials were characterized by XRD, SEM, inverted stand optical microscope analysis, and mercury porosimetry method. Amoxicillin, amoxicillin + clavulanic acid, and erythromycin were the antibiotics used. Release properties during 28 days from the hydroxyapatite (HA) granules, and two types of nanoHA microspheres were investigated. Biocompatibility was assessed by cytotoxicity assays. HA granules were inadequate, releasing all antibiotic during the first hours. The concentration of antibiotics released in the first days from HA-2 was higher than from HA-1 microspheres, because of the increased porosity and surface area. The release profiles (fast initial release followed by long-term sustained release) of effective doses of antibiotics make these systems good alternatives for antibiotics delivery. Osteoblasts proliferated well on both types of microspheres, being cell growth enhanced in the presence of antibiotics. Erythromycin presented the most beneficial effect. Combining the sustained antibiotic release with the osteoconduction, resorbability, and potential use as injectable bone filling material of porous HA microspheres, these systems provided a forth fold beneficial effect.

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Section: Discussionsupporting

confidence: 87%

“…Several have reported the use of hydroxyapatite (HA) as a drugs carrier because of its adequate mechanical properties and composition similarity to mineral bone and suggest that it may be used as a bone substitute 6, 13–16…”

Section: Introductionmentioning

confidence: 99%

Nanohydroxyapatite microspheres as delivery system for antibiotics: Release kinetics, antimicrobial activity, and interaction with osteoblasts

Ferraz

Pataquiva-Mateus

Sousa

et al. 2007

J Biomedical Materials Res

124

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“…Recently, research has been focused on adsorption separation technique due to its suitability for batch and continuous modes, ease of operation, possibility of regeneration and reuse, and low capital cost [13]. Low adsorption capacity of MNZ has been reported on soil, clay, zeolite, and commercial hydroxyapatite [14][15][16][17]. Recently, good adsorption has been detected on activated carbon prepared from an industrial waste, petroleum coke, by KOH conventional activation due to the ability of alkaline hydroxide activator KOH to produce a microporous activated carbon with high surface area and narrow pore size distribution [18].…”

Section: Introductionmentioning

confidence: 99%

Microporous activated carbon from Siris seed pods by microwave-induced KOH activation for metronidazole adsorption

Ahmed¹,

Theydan²

2013

Journal of Analytical and Applied Pyrolysis

120

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“…From this time on the commonly used insertion test with an outsourcing time of 24 h makes more sense. The concentration of the antibiotics in the eluate was determined by UV spectroscopy [19,20]. For each antibiotic a calibration curve was recorded in steps of 5 mg/l, 10 mg/l, 20 mg/l, 40 mg/l, and 80 mg/l.…”

Section: Methodsmentioning

confidence: 99%

Standardized release measurements for antibiotics from polymethylmethacrylate bone cement under constant flow

Braun¹,

Frommelt²,

Thulĺ³

2006

BIOmaterialien

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Polymethylmethacrylate bone cement is used for shaft fixation of artificial hip and knee joints. The reliable method has the advantage of a nearly immediate loading capacity after the implantation. In cases of hazards due to postoperative biomaterial associated infections [1] anti-inflammatory therapies are difficult [2][3][4], lifelong and often to press an explantation of the implant. A prophylactic measure is the use of antibiotic loaded cement [5,6] with the goal to reach sufficiently high level of antibiotics in the immediate vicinity of the implant, without stressing the organism excessively and the hope to avoid resistance. Oral intakes of antibiotics are mostly ineffectively because of reduced diffusion in the bone sphere. Commercially available are gentamicin loaded bone cements with an antibiotic content of about 2.5 %. In cases, if special antibiotics are required, the active incredients, one or two [7] are added to the cement powder by the physician during the operation. A fraction up to 10 % is in use. There is no knowledge about the influence of constituents of antibiotics to the cement powder with respect to the mechanical stability. But some recommendations are announced which say that a maximum of 10 % of incredients should not be exceeded [8]. The other constraint is the minimal amount of antibiotics to be effective against bacteria. Generally 90 % of the incorporated constituents are retained in the PMMA matrix [9,10], so that only small amounts are available in particular if a long term therapy is aspired. Hence the increase of bacterial resistance, mainly against bacteria responsible for infections on orthopaedic implants, leads to an increasing interest and search for new effective antimicrobial agents which have to be admixed to the cement by the clinician because commercial not available. There are some methods published applied for the determination of the antibiotic release rate. Although not validated results are available, it is generally accepted that the release rate during the first hours shows high values whereas the values strongly decrease in the long term application and finally are stabilized on a very low level over a few weeks [11][12][13]. The release kinetic is controlled by a combination of surface roughness and porosity [14]. A high roughness enlarges the surface and the amount of interfacial bonded agent molecules. Porous materials, permeable by the body electrolyte [15,16] deliver effective molecules out of the region close to the surface. Porosity itself depends on the addition of antibiotics which leave pores after release [17]. Autoren

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Development of a system to adsorb drugs onto calcium phosphate materials

Cited by 21 publications

References 16 publications

Nanohydroxyapatite microspheres as delivery system for antibiotics: Release kinetics, antimicrobial activity, and interaction with osteoblasts

Nanohydroxyapatite microspheres as delivery system for antibiotics: Release kinetics, antimicrobial activity, and interaction with osteoblasts

Microporous activated carbon from Siris seed pods by microwave-induced KOH activation for metronidazole adsorption

Standardized release measurements for antibiotics from polymethylmethacrylate bone cement under constant flow

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