Adsorption and release of ofloxacin from acid- and heat-treated halloysite

Wang, Aiqin; Zhang, Junping; Zheng, Yue

doi:10.1016/j.colsurfb.2013.08.036

Cited by 95 publications

(54 citation statements)

References 38 publications

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“…Due to its low cost, wide availability, and interesting physico-chemical properties [1], halloysite has attracted considerable attention for applications in many fields [2]. In particular halloysite, being a biocompatible nanomaterial, is perspective as drug carrier and delivery [3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Direct chemical grafted curcumin on halloysite nanotubes as dual-responsive prodrug for pharmacological applications

Massaro

Amorati

Cavallaro

et al. 2016

Colloids and Surfaces B: Biointerfaces

145

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Section: Introductionmentioning

confidence: 99%

Direct chemical grafted curcumin on halloysite nanotubes as dual-responsive prodrug for pharmacological applications

Massaro

Amorati

Cavallaro

et al. 2016

Colloids and Surfaces B: Biointerfaces

145

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“…The investigation in using HNTs as a drug delivery system (Levis and Deasy 2002) and the study of the release of chemicals, especially pharmaceuticals, from halloysite and halloysite-based polymeric composites has been tackled in the recent past (Levis and Deasy 2003;Lvov et al 2008;Ghebaur et al 2012;Wang et al 2014). The release kinetics of chemicals loaded into HNT has been modeled thus far using the RitgerPeppas (Ritger and Peppas 1987a, b) or related equations (Veerabadran et al 2007;Ward et al 2010).…”

Section: Release Kineticsmentioning

confidence: 99%

The effect of charge on the release kinetics from polysaccharide–nanoclay composites

et al. 2015

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The objective of this study was to integrate inorganic halloysite nanotubes (HNT) with chitosan and hyaluronic acid to obtain hybrid nanocomposites with opposing charges and to investigate their potential in the controlled release of drug model probes. Two oppositely charged polysaccharides, chitosan and hyaluronic acid, were selected for their biocompatibility and their importance in biomedical applications. The high surface area and the hollow nanometric-sized lumen of HNT allowed for the efficient loading of rhodamine 110 and carboxyfluorescein, used as models for oppositely charged drugs. In the case of chitosan, the preparation of the nanocomposite was carried out exploiting the electrostatic interaction between the polymer and HNT in water, while with hyaluronic acid, a covalent functionalization strategy was employed to couple the polymer with the clay. Nanocomposites were characterized with thermal, microscopic, and spectroscopic techniques, and the release kinetics of the model compounds was assessed by fluorescence measurements. The release curves were fitted with a model able to account for the desorption process from the external and the internal halloysite surfaces. The results show that both polymeric coatings alter the release of the probes, indicating a key role of both charge and coating composition on the initial and final amount of released dye, as well as on the rate of the desorption process.

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“…The water molecules are sitting between two consecutive layers (the unit layers of a hollow tubular structure are separated by a monolayer of water molecules) and create slight differences in the relative orientation between neighboring layers might give rise to the differences in the symmetry of the final structure [18]. When n=2 (molecular formula), HNTs are in a hydrated state with one layer of water in the interlayer spaces.…”

Section: Hnts Characteristicsmentioning

confidence: 99%

“…2b) Grafting silanes via condensation between the hydrolyzed silanes and the surface hydroxyl groups of the HNTs [40] Increase the interfacial adhesion of the HNTs γ-glycidoxypropyltrimethoxysilane; 3-(trimethoxysilyl)propyl methacrylate [7,22] Surface modifier (introduce double bonds onto the surface of HNTs to form sites for polymerization) [45,46] Acid and heat activation Dehydroxylation of the structural aluminol groups: decrease of the adsorption capacity for cationic drug; HNTs becomes amorphous Structural rearrangement: changes in the pore structure and surface properties; remove the physically bounded water [18] Table II -Examples of purification, modification and functionalization process of halloysite nanotubes (HNTs).…”

Section: [Tabela I -Principais Características Físicas E Químicas Dosmentioning

confidence: 99%

Halloysite nanotubes-polymeric nanocomposites: characteristics, modifications and controlled drug delivery approaches

2017

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Halloysite nanotubes (HNTs) are aluminosilicate nanoclay mineral which have a hollow tubular structure and occurs naturally. They are biocompatible and viable carrier for inclusion of biologically active molecules due to the empty space inside the tubular structure. In this article, the HNTs main characteristics, and the HNTs-polymeric nanocomposite formation and their potential application as improvement of the mechanical performance of polymers and entrapment of hydrophilic and lipophilic substances are summarized. Recent works covering the increment of HNTs-polymeric nanocomposites and presenting promising employment of these systems as nanosized carrier, being suitable for pharmaceutical and biomedical applications, based on earlier evidence in literature of its nature to sustain the release of loaded drugs, presenting low cytotoxicity, and providing evidence for controlled drug delivery are reviewed. Keywords: nanoclay, bio-nanocomposites, functionalization, sustained drug release, nanotechnology. Resumo Nanotubos de haloisita (NTH) são nanoargilas de silicato de alumínio com estrutura naturalmente tubular. Eles são biocompatíveis e apresentam viabilidade como carreador de moléculas biologicamente ativas devido ao seu espaço interno na estrutura tubular. Neste artigo as principais características dos NTH e a obtenção de nanocompósitos poliméricos com NTH, e suas potenciais aplicações para o aperfeiçoamento das propriedades mecânicas dos polímeros

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Adsorption and release of ofloxacin from acid- and heat-treated halloysite

Cited by 95 publications

References 38 publications

Direct chemical grafted curcumin on halloysite nanotubes as dual-responsive prodrug for pharmacological applications

Direct chemical grafted curcumin on halloysite nanotubes as dual-responsive prodrug for pharmacological applications

The effect of charge on the release kinetics from polysaccharide–nanoclay composites

Halloysite nanotubes-polymeric nanocomposites: characteristics, modifications and controlled drug delivery approaches

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