Adrenal Cholesterol in the Scorbutic Guinea Pig

Oesterling, M. Jane; Long, C. N. H.

doi:10.1126/science.113.2931.241

Cited by 21 publications

(5 citation statements)

References 7 publications

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“…It appears that ascorbic acid is not essential for the elaboration of corticosteroids (Eisenstein & Shank, 1951) and that the increased adrenocortical activity in the terminal stages of scurvy is caused by the severe stress imposed by vitamin C deficiency (Howard & Cater, 1959;Oesterling & Long, 1951). A drop in adrenal corticosteroid concentration occurs in the final stages of ascorbic acid deficiency, possibly because the rate of synthesis of the corticosteroids is incapable of matching the rate of their release.…”

Section: Discussionmentioning

confidence: 99%

“…Although this fall in adrenal ascorbic acid concentration is associated with increased adrenocortical activity, the precise function of the vitamin in the synthesis and release of corticosteroids is not understood. The concentration of ascorbic acid in the adrenal glands of the guinea-pig can be reduced rapidly to scarcely detectable levels by diets deficient in ascorbic acid (Oesterling & Long, 1951) and this paper describes the results of experiments in which pituitary adrenocortical activity was studied in guinea-pigs made scorbutic in this way.…”

Section: Introductionmentioning

confidence: 99%

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Ascorbic acid deficiency and pituitary adrenocortical activity in the guinea‐pig

Hodges

Hotston

1970

British J Pharmacology

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Summary . Guinea‐pigs kept on a diet deficient in ascorbic acid lost weight and became moribund in about 24 days. . The adrenal ascorbic acid concentration fell rapidly during the first 2 weeks, and the plasma corticosteroid concentration and 17‐oxogenic steroid excretion rose sharply in the third week of ascorbic acid deficiency. . Both histamine and corticotrophin increased the plasma corticosteroid concentration when injected during the second week but failed to change the pre‐existing high concentration of the steroid in the third week of ascorbic acid deficiency. . The observations confirm that ascorbic acid is not involved in corticoidogenesis and that scurvy is a severe stress which increases adrenocortical activity to such an extent that the rate of synthesis of corticosteroids is incapable of matching the rate of their release.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ascorbic acid deficiency and pituitary adrenocortical activity in the guinea‐pig

Hodges

Hotston

1970

British J Pharmacology

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“…For instance, Jailer & Boas (54) found that although chronic adminis tration of ACTH to the young chick caused adrenal hypertrophy, no altera tion of the adrenal ascorbic acid content was observed; whereas, in thc scorbutic guinea pig, it was possible to induce an increase of adrenal activity with ACT, H (55,56,57). The fact that the particulars about the relationship of ascorbic acid content to the adrenal function as a whole are still obscured, may explain the difficulties in assessing ACTH activity by the ascorbic acid depleting test.…”

Section: Anterior Pituitary Hormonesmentioning

confidence: 99%

Chemistry of the Nonsteroid Hormones

Li¹,

Harris²

1952

Annu. Rev. Biochem.

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1 The present review covers the period from September, 1949 to December, 1951 The sections on the posterior lobe hormones and insulin were written by the junior author.3 Some of the topics omitted from our discussion have been the subject of recent reviews elsewhere; namely, relaxin (1), thyroxine and thyroglobulin (2, 3, 3a), and the gastrointestinal hormones (4). ' 603 Annu. Rev. Biochem. 1952.21:603-632. Downloaded from www.annualreviews.org Access provided by University of Michigan -Ann Arbor on 02/05/15. For personal use only. Quick links to online content Further ANNUAL REVIEWS Annu. Rev. Biochem. 1952.21:603-632. Downloaded from www.annualreviews.org Access provided by University of Michigan -Ann Arbor on 02/05/15. For personal use only.

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“…Several reports have appeared on the effect of ascorbic acid deficiency on metabolic processes (Sealock & Silberstein, 1940;Banerjee, Biswas & Singh, 1958Ganguli & Roy, 1954;Ganguli & Banerjee, 1961;Guchhait & Ganguli, 1961a;Banerjee & Ganguli, 1962). The metabolism of cholesterol was found to be altered in scorbutic guinea pigs (Oesterling & Long, 1951;Banerjee & Deb, 1951;Belavady & Banerjee, 1954;Guchhait & Ganguli, 1960;. Oesterling & Long (1951) and Banerjee & Deb (1951) have reported a diminished concentration of adrenal cholesterol in scurvy.…”

mentioning

confidence: 98%

“…The metabolism of cholesterol was found to be altered in scorbutic guinea pigs (Oesterling & Long, 1951;Banerjee & Deb, 1951;Belavady & Banerjee, 1954;Guchhait & Ganguli, 1960;. Oesterling & Long (1951) and Banerjee & Deb (1951) have reported a diminished concentration of adrenal cholesterol in scurvy. Belavady & Banerjee (1954) observed that scorbutic guinea pigs excrete a smaller amount of injected p-aminobenzoic acid in the acetylated form and concluded that the decrease in the concentration of adrenal cholesterol in scurvy may be attributed to diminished acetylation in the body.…”

mentioning

confidence: 98%