Adolescent overweight and obesity and the risk of papillary thyroid cancer in adulthood: a large-scale case-control study

Abstract

this study aimed to investigate the association between adolescent overweight and obesity and ptc risk in adulthood. We conducted a case-control study in the Republic of Korea with 1,549 PTC patients and 15,490 controls individually matched for age and sex. We estimated body mass index (BMI) at age 18 years from self-reported weight at this age. Compared with BMI < 23.0 at age 18 years, BMI ≥ 25.0 at age 18 years was associated with higher PTC risk (odds ratio [OR] = 4.31, 95% confidence interval [CI]: 3.57, 5.22). The association between BMI ≥ 25.0 at age 18 years and PTC risk was stronger among men (OR = 6.65, 95% CI: 4.78, 9.27) than among women (OR = 3.49, 95% CI: 2.74, 4.43), and stronger among individuals with current BMI ≥ 25.0 (OR = 8.21, 95% CI: 6.34, 10.62) than among those with current BMI < 25.0 (OR = 2.21, 95% CI: 1.49, 3.27). Among PTC patients, BMI ≥ 25.0 at age 18 years was associated with extra-thyroidal extension and T stage ≥2, but not with N stage ≥1 or BRAF V600E mutation. Adolescent overweight and obesity was associated with higher risk of ptc in adulthood. our results emphasise the importance of weight management in adolescence to decrease the ptc risk. conclusionWe found that adolescent overweight and obesity was associated with higher risk of PTC. The association was stronger among men than women and stronger among individuals with current BMI ≥ 25 than those with current BMI < 25. Adolescent overweight and obesity was also associated with higher tumour aggressiveness among PTC patients. The results of the present study provide additional evidence that public health concerns and policy intervention are needed for weight management in adolescence to decrease the PTC risk.

Obesity and Thyroid Cancer Risk: An Update

“…Kim and coworkers conducted a case-control study in the young Korean population (18 years old) and showed that both men and women with BMI ≥ 25 had a higher risk of developing PTC than those with BMI < 23 [33].…”

Association between Body Mass Index and Severity According of Classification of Thyroid Cancer

“…Recent studies are also reporting that obesity is associated with increased incidence of thyroid cancer [21]. Kim et al [21].…”

“…Recent studies are also reporting that obesity is associated with increased incidence of thyroid cancer [21]. Kim et al [21]. Performed a case-control study in which the authors hypothesized that overweight and obesity would be associated with higher risk of PTC in an adolescent Korean population (BMI≥25 at age 18 years).…”

The association of obesity with thyroid carcinoma risk

“…A case‐control study in the Republic of Korea provided moderate evidence that overweight and obesity in adolescence were correlated with high PTC risk in adulthood, and the association between obesity in adolescence at age 18 years and PTC risk in adulthood was stronger in men than in women 34 . In addition to BMI, a cohort study also showed that taller height during childhood and adolescence was associated with an increased risk of adult TC 35 .…”

“…Among TC survivors in a case‐control study, obesity at age 18 years was associated with cancer‐related aggressive behavior later in life, such as extrathyroidal extension and tumor size, 34 and excess body fatness in early life will increase adverse overcomes in TC survivors. A higher BMI in TC survivors was positively associated with a higher recurrence risk of TC 37 .…”