The association of obesity with thyroid carcinoma risk

Abstract

Background The prevalence of obesity and an increased incidence of thyroid carcinoma (TC) threaten public health in parallel on a global scale. Sufficient evidence supports excess body fatness in thyroid carcinogenesis, and the role and anthropometric markers of obesity have been causally associated with the rising risk of TC. Methods A literature search was conducted in PubMed. Studies focused on the effect of obesity in TC. Results This review mainly discusses the global incidence and prevalence of obesity‐related TC. We also review the role of obesity in TC and potential clinical strategies for obesity‐related TC. Conclusions Excess body fatness in early life and TC survival initiate adverse effects later in life.

Landscape of gene mutation in Chinese thyroid cancer patients: Construction and validation of lymph node metastasis prediction model based on clinical features and gene mutation marker

“…21 At the same time, obesity, estrogen, radiation exposure, iodine intake, and other factors, have led to the high incidence of thyroid cancer in recent years. [22][23][24] The occurrence and development of TC is a process involved multiple genetic alterations, including gene mutations, rearrangements, fusions, and methylation of oncogenes and tumor suppressor genes. PTC is the most common type of thyroid cancer, although a better outcome can be expected for PTC patients, 9.1%-38% of them will finally step into the status of lateral lymph node metastasis, which seriously affects the prognosis.…”

“…The current mainstream view is that due to the high sensitivity and strong accuracy of high‐resolution ultrasound diagnostic technology, smaller and earlier thyroid nodules are continuously detected, and thyroid cancer accounts for about 5%–15% of them 21 . At the same time, obesity, estrogen, radiation exposure, iodine intake, and other factors, have led to the high incidence of thyroid cancer in recent years 22–24 …”

“… 21 At the same time, obesity, estrogen, radiation exposure, iodine intake, and other factors, have led to the high incidence of thyroid cancer in recent years. 22 , 23 , 24 …”

Tumor Microbial Communities and Thyroid Cancer Development—The Protective Role of Antioxidant Nutrients: Application Strategies and Future Directions

“…Nutritional habits associated with a Western-style diet represent modifiable factors related to an increased risk of developing hypertension, hypercholesterolemia, overweight/obesity, and inflammation, which in turn imply a higher risk for disease conditions, such as metabolic syndrome, diabetes, cardiovascular disease, and cancer [175,176]. Notably, current evidence suggests a relevant role for obesity as a risk factor for differentiated TC [177,178], with no apparent effect on cancer aggressiveness [179,180]. Furthermore, the few studies conducted with the aim of exploring the association between dietary habits and the risk for TC highlighted that while dietary patterns of fruits, vegetables, seafood, and milk and dairy products led to a reduced risk of TC [10,181,182], the Western dietary pattern-starchy foods, sweets, and products rich in salt and fat-showed a significantly positive association with TC risk [10,183].…”