Adjuvants and Immune Regulation by Lymphoid Cells

Waksman, Byron H.

doi:10.1007/978-3-642-67809-7_2

Cited by 22 publications

(7 citation statements)

References 114 publications

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“…from one fish. Lance, 1978;Waksman, 1979;Allison & Byars, 1986;Anderson, 1992). Gallily & Garvey (1968) and Stensvåg et al (1995) showed that particulate antigens were more easily ingested and processed in macrophages compared to soluble antigens.…”

Section: Discussionmentioning

confidence: 99%

Microsilica as antigen carrier and adjuvant in the Atlantic salmon (Salmo salarL.)

Rokstad

Bøgwald

Jørgensen

1996

Fish & Shellfish Immunology

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Section: Discussionmentioning

confidence: 99%

Microsilica as antigen carrier and adjuvant in the Atlantic salmon (Salmo salarL.)

Rokstad

Bøgwald

Jørgensen

1996

Fish & Shellfish Immunology

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“…48, 1985 on September 6, 2020 by guest http://iai.asm.org/ Downloaded from inducers of cell-mediated responses (45). In general, poorly soluble antigens which persist in the host for an extended period of time, especially in association with cell membranes, are good inducers of cellular immunity (47).…”

Section: Discussionmentioning

confidence: 99%

Immunization against experimental murine salmonellosis with liposome-associated O-antigen

Desiderio¹,

Campbell²

1985

Infect Immun

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Partially delipidated Salmonella typhimurium (0-1,4,5,12) lipopolysaccharide was incorporated into small multilamellar liposomes composed of either naturally occurring or synthetic phospholipids. Vaccination of mice with the liposome-lipopolysaccharide complexes induced a cellular response specific for 0-1,4,5,12 determinants, as determined by the development of a delayed-type hypersensitivity reaction. The liposome-lipopolysaccharide vaccines were significantly more effective, compared with other nonviable vaccines tested, in protecting mice against a lethal intravenous challenge infection with virulent S. typhimurium. Protection afforded by the liposome-lipopolysaccharide vaccines was comparable to that conferred by a live S. typhimurium vaccine. Results suggest that liposome-induced modulation of the host immune response in favor of cell-mediated immunity may be more efficacious in preventing diseases in which cell-mediated immunity is of prime importance.

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“…Reviewers had frequently noted that many adjuvants are surface active agents while most common surface active agents are not adjuvants (Waksman, 1979;Hunter, 1980;Warren et aI, 1986). We hypothesized that surface activity was a key factor in adjuvant activity and began a search for potentially informative experimental models.…”

Section: Development Of a Liposomal Sporozoite Vaccinementioning

confidence: 99%

Immunological Adjuvants and Vaccines

Gregoriadis¹,

Allison²,

Poste³

1989

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All rights reservedNo part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written permission from the Publisher PREFACE Vaccination, chiefly responsible for the eradication of smallpox and the control of poliomyelitis and German measles in man and of foot-andmouth, Marek's and Newcastle disease in domestic animals, remains the best answer to infectious diseases. Early vaccines were live wild type organisms but these have been largely replaced by attenuated or killed organisms or by purified components (subunits) thereof. More recently, developments in recombinant DNA techniques, the advent of monoclonal antibodies and progress in our understanding of the immunological structure of proteins, have laid the foundations for a new generation of vaccines. For instance, subuni t vaccines have been produced through gene cloning and a number of peptides mimicking small regions of proteins on the outer coat of viruses and capable of eliciting virus neutralizing antibodies, have been synthesized. Such vaccines are defined at the molecular level, can elicit immune responses controlling specific infectious organisms and are, thus, potentially free of the problems inherent in conventional ones. However, because subunit and peptide vaccines are only weakly or non-immunogenic, they require the presence of immunological adjuvants. These are a diverse array of agents that promote specific humoural and/or cell-mediated immunity responses to antigens. This book contains the proceedings of the 1st NATO Advanced Studies Institute "Immunological Adjuvants and Vaccines" held in Cape Sounion Beach, Greece during 24 June-5 July, 1988. It deals with traditional and modern immunological adjuvants as applied to a variety of conventional and new generation vaCCines, mechanisms of adjuvanticity and related immune responses as well as optimization of such responses by the use of appropriate adjuvant formulations. We express appreciation to Professors Ruth Arnon and J.H.L. Playfair for their advice in the planning of the ASI, to Dr. G. Deliconstantinos Wl10, as Chairman of the local committee, contributed most effectively to its success, and to Mrs. A. Massaro for her help with practical aspects of the ASI. We are particularly grateful to Hrs. Susan

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Adjuvants and Immune Regulation by Lymphoid Cells

Cited by 22 publications

References 114 publications

Microsilica as antigen carrier and adjuvant in the Atlantic salmon (Salmo salarL.)

Microsilica as antigen carrier and adjuvant in the Atlantic salmon (Salmo salarL.)

Immunization against experimental murine salmonellosis with liposome-associated O-antigen

Immunological Adjuvants and Vaccines

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