Adjuvant P40 et réactions cutanées à l'antigène

Hénocq, E; Bazin, J. C.; Bizzini, B; Reynier, J

doi:10.1016/s0399-077x(78)80067-5

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…P40 is a particulate fraction or fragment isolated from Corynebacterium granulosum (now called Propionibacterium acnes ), that was first described in 1970 by a group of researchers at the Pasteur Institute in Paris, and has previously been studied for its pleiotropic effect ( 1 ). P40 has been demonstrated to perform a wide spectrum of pharmacological functions including, antitumor effects via a marked inhibitory activity towards ‘liquid’ and solid tumors in mice ( 2 ), adjuvant effects ( 3 ), immunomodulatory effects ( 4 ), effects on phagocytosis ( 5 , 6 ), antimicrobial properties on bacterial infections ( 7 ), effects on viral infections ( 8 ), cytokine induction ( 9 ) and effects on Escherichia coli infections ( 10 ). In animal models, it has been demonstrated that P40 exhibits dichotomous action in immune-mediated diseases by increasing the production of antibodies against sheep red blood cells and augmenting the resistance of mice towards bacterial infections ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

“…In animal models, it has been demonstrated that P40 exhibits dichotomous action in immune-mediated diseases by increasing the production of antibodies against sheep red blood cells and augmenting the resistance of mice towards bacterial infections ( 4 ). P40 may also enhance the primary and secondary immune responses to a stimulus involving a particulate antigen, and under defined conditions, overcome the immunosuppressive effects of cyclophosphamide ( 4 , 11 ).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of hyaluronic acid-P40 conjugated cream in a mouse model of dermatitis induced by oxazolone

Mangano

Vergalito

Mammana

et al. 2017

Experimental and Therapeutic Medicine

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P40 is a particulate fraction or fragment isolated from Corynebacterium granulosum, which exhibits a wide spectrum of pharmacological functions including antitumor, antibacterial, phagocytic, antiviral and cytokine induction effects. In the present study, the immunomodulatory potential of P40-conjugated with hyaluronic acid was assessed in a mouse model of dermatitis induced by oxazolone. Oxazolone-induced allergic contact dermatitis is a T cell-mediated Th2-like hypersensitivity reaction, which mimics the corresponding reaction in humans. Female cluster of differentiation-1 mice were sensitized on days 0 and 1 by the application of 2% oxazolone onto a shaved back. The disease was induced by re-challenge on day 7 using 15% oxazolone in the inner and outer of the left ears of the mice. Mice were topically treated with hyaluronic acid-P40 conjugate cream or with placebo to the inner and outer surface of the left ear for 7 consecutive days starting from 1 h after the sensitization. A significant reduction in ear thickness and weight and in edema and leukocyte recruitment were observed in the mice treated with hyaluronic-P40 conjugate cream compared with mice treated with the cream base alone (P<0.05). Thus, P40-conjugated with hyaluronic acid may constitute an innovative dermatitis treatment.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of hyaluronic acid-P40 conjugated cream in a mouse model of dermatitis induced by oxazolone

Mangano

Vergalito

Mammana

et al. 2017

Experimental and Therapeutic Medicine

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Treatment of relapsing chronic infections of the respiratory tract: a comparative study of the effectiveness of non specific immunotherapy with the immunoadjuvant p40 and of vaccinotherapy

Hénocq

Veronesi

Bazin

et al. 1984

Rev. Inst. Med. trop. S. Paulo

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The treatment of relapsing chronic infections (RCI) encounters many difficulties. In the present study, the use of the immuno adjuvant P40 either alone or in association with vaccinotherapy for the treatment of RCI turned out to be very effective, whereas vaccinotherapy alone was not. It is hypothesized that cell-mediated immunity may play a major role in controlling RCI, since the clinical improvement of the patients kept up with the positivation of previously negative skin tests carried out with either the specific infecting agent or with recall-anti gens.

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Effect of Immunostimulation with theCorynebacterium granidosumDerived Immunomodulator P40 on Patients with Recurring Respiratory Infections

et al. 1984

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Adjuvant P40 et réactions cutanées à l'antigène

Cited by 3 publications

References 6 publications

Evaluation of hyaluronic acid-P40 conjugated cream in a mouse model of dermatitis induced by oxazolone

Evaluation of hyaluronic acid-P40 conjugated cream in a mouse model of dermatitis induced by oxazolone

Treatment of relapsing chronic infections of the respiratory tract: a comparative study of the effectiveness of non specific immunotherapy with the immunoadjuvant p40 and of vaccinotherapy

Effect of Immunostimulation with theCorynebacterium granidosumDerived Immunomodulator P40 on Patients with Recurring Respiratory Infections

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