Adiposity is not beneficial to bone mineral density in 0–5 year old Chinese children: The Jiangsu bone health study

Yan, Zhao; Qin, Rui; Ma, Xianghua; Qin, Zhen-Ying; Yang, Zhenghong; Hong, Hong; Lv, Heyu; Ye, Kan; Wei, Yarong; Zheng, Wen; Qi, Hongxia; Ni, Yufei; Zhang, Li; Yan, Juhua; Liu, Guoqin; Wu, Aiping

doi:10.1016/j.orcp.2019.10.011

Cited by 8 publications

(11 citation statements)

References 43 publications

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“…t BMD was positively correlated with age, height/length, and inversely with BMI. The BMD gradually increased in the range within 21.2kg, but began to gain slowly and even decreased when the body weight exceeded 21.2kg (Zhao et al, 2020).…”

Section: Children and Adolescentsmentioning

confidence: 96%

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Obesity and Bone Health: A Complex Link

Hou

et al. 2020

Front. Cell Dev. Biol.

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So far, the connections between obesity and skeleton have been extensively explored, but the results are inconsistent. Obesity is thought to affect bone health through a variety of mechanisms, including body weight, fat volume, bone formation/resorption, proinflammatory cytokines together with bone marrow microenvironment. In this review, we will mainly describe the effects of adipokines secreted by white adipose tissue on bone cells, as well as the interaction between brown adipose tissue, bone marrow adipose tissue, and bone metabolism. Meanwhile, this review also reviews the evidence for the effects of adipose tissue and its distribution on bone mass and bone-related diseases, along with the correlation between different populations with obesity and bone health. And we describe changes in bone metabolism in patients with anorexia nervosa or type 2 diabetes. In summary, all of these findings show that the response of skeleton to obesity is complex and depends on diversified factors, such as mechanical loading, obesity type, the location of adipose tissue, gender, age, bone sites, and secreted cytokines, and that these factors may exert a primary function in bone health.

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Section: Children and Adolescentsmentioning

confidence: 96%

“…Notably, Zhao et al (2020) recently found that obesity had no benefit for BMD in Chinese children aged 0-5 years. t BMD was positively correlated with age, height/length, and inversely with BMI.…”

Section: Children and Adolescentsmentioning

confidence: 99%

Obesity and Bone Health: A Complex Link

Hou

et al. 2020

Front. Cell Dev. Biol.

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“…Children during the first 5 years of life were recruited from 12 Children's Health Care Centers in 10 cities in Jiangsu Province, China. The sampling method and inclusion/exclusion criteria have been reported in a previous study 19 . Serum 25(OH)D concentration was added to the measures in the previous study and the present study.…”

Section: Methodsmentioning

confidence: 99%

Vitamin D status and its dietary and lifestyle factors in children during the first 5 years of life: A cross‐sectional multicentre Jiangsu bone study

Yan

Qin

Hong³

et al. 2021

J Human Nutrition Diet

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Background To explore the vitamin D status with its demographic and lifestyle factors including dietary, supplementation, and physical activity in 0–5 years old children. Methods This was a large population‐based cross‐sectional multicentre study in which the children were recruited from 12 Children’s Health Care Centers by a stratified cluster random‐sampling method in 10 cities in Jiangsu Province, China. Results A total number of 5289 children were investigated. The prevalence of vitamin D deficiency was 30.1%. The concentration of 25 hydroxyvitamin D was 64.0 (46.3–83.0) nmol mL−1 after adjustment for covariates. Children with higher risk of vitamin D deficiency were more likely to be at older age, girls, survey conducted in spring, location in southern Jiangsu province, residence in urban, outdoor activity < 2 h day−1 (all p < 0.05). Moreover, those with lower risk were more likely to be the number of parity ≥ 2 times, vitamin D supplementation from birth to 6 months, the initial time of vitamin D supplementation after birth ≤ 1 months, vitamin D and calcium supplementation in the last 3 months, and dose of vitamin D supplementation > 400 IU day−1 (all p < 0.05). Children with preferences for sweets, meat consumption > 150.0 g day−1, milk consumption < 250 mL day−1, time of sleeping < 10 h day−1 had higher risks of vitamin D deficiency. However, these relationships were affected by demographics. Conclusions Vitamin D status during the first five years of life was suboptimal and was associated with demographic and lifestyle determinants including milk, meat, sweets, vitamin D and calcium supplementation, sleeping and outdoor activity.

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“…In addition, obese individuals, especially those elderly people, have a negative association between body fat and BMD ( 12 ). Obesity is not conducive to the bone mineral density of children aged 0–5 years in China ( 13 ). The mechanism and factors that affect bone density appear to be especially complex.…”

Section: Introductionmentioning

confidence: 99%

The causal impact of childhood obesity on bone mineral density and fracture in adulthood: A two-sample Mendelian randomization study

et al. 2022

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Observational studies have indicated the associations between obesity with bone mineral density (BMD) and fracture but yield inconsistent results. The impact of childhood obesity on bone health in adulthood is even less clear. The present study adopted the Mendelian randomization methods to determine whether the genetically predicted childhood obesity was causally associated with BMD and the risk of fracture. Genetic variants were extracted from genome-wide association studies (GWAS) to identify childhood obesity loci [IEU open GWAS project: childhood obesity (ID: ieu-a-1096)] and single nucleotide polymorphisms (SNPs) as instrumental variables to investigate causality. We used two-sample univariable Mendelian randomization (MR) to estimate causal relationships between childhood obesity on BMD and fracture subtypes based on SNPs from European samples. To avoid bias, Cochran's Q test and leave-one-out variant analysis were performed. The MR analysis shows strong evidence that childhood obesity is causally associated with eBMD (OR 1.068, 95% CI 1.043–1.095, P < 0.001) and a weak decreased risk of leg fracture (OR 0.9990, 95% CI 0.9981–0.9999, P =0.033) based on the inverse variance weighting (IVW) method. After adjusting for diabetes and adult obesity, the results of eBMD remained the same. The MR analysis revealed sufficient evidence to indicate childhood obesity was causally associated with increased BMD and decreased risk of leg fracture in adults. Childhood obesity could be taken into consideration when assessing eBMD.

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Adiposity is not beneficial to bone mineral density in 0–5 year old Chinese children: The Jiangsu bone health study

Cited by 8 publications

References 43 publications

Obesity and Bone Health: A Complex Link

Obesity and Bone Health: A Complex Link

Vitamin D status and its dietary and lifestyle factors in children during the first 5 years of life: A cross‐sectional multicentre Jiangsu bone study

The causal impact of childhood obesity on bone mineral density and fracture in adulthood: A two-sample Mendelian randomization study

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