Obesity and Bone Health: A Complex Link

Hou, Jing; He, Chen; He, Wenzhen; Yang, Mingzhi; Luo, Xi; Li, Changjun

doi:10.3389/fcell.2020.600181

Cited by 77 publications

(76 citation statements)

References 214 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Proposed factors include estrogen, insulin, IGF-1, cortisol, adipokines, incretins, calcium, vitamin D and parathormone [11,14,24,36,37]. Nevertheless, connections are not straightforward since postoperative changes in some are inconsistent, while others have an unclear impact on bone health [38,39]. Peptide YY (PYY) is a molecule that has recently gained interest in light of its role in the gut-bone axis.…”

Section: Discussionmentioning

confidence: 99%

Bone Mineral Density Trends During the First Year After Laparoscopic Sleeve Gastrectomy—a Cohort Study on 241 Patients

et al. 2021

View full text Add to dashboard Cite

Purpose Laparoscopic sleeve gastrectomy (LSG) is an effective weight loss procedure, but detrimental effects on bone health have been described. We aimed to assess the dynamics of regional and total bone mineral density (BMD) in a cohort of patients undergoing LSG and to capture gender differences in terms of evolution. Materials and Methods We conducted a retrospective study on 241 patients who underwent LSG to determine the regional and total BMD changes at 6 and 12 months after the intervention. Results One hundred ten males and 140 females (97 pre-, 43 postmenopausal) were included. Mean baseline body mass index (BMI) was 44.16 ± 6.11 kg/m2 in males and 41.60 ± 5.54 kg/m2 in females, reaching 28.62 ± 4.26 kg/m2 and 27.39 ± 4.2 kg/m2, respectively, at 12 months. BMD showed a continuous decline, with significant loss from 6 months postoperatively. There was a positive correlation between BMD and BMI decline at 12 months (r = 0.134, p < 0.05). Total BMD loss at 12 months was significantly greater in males than premenopausal females, independent of BMI variation and age. During the first 6 months, men lost significantly more bone mass than premenopausal and postmenopausal women (BMD variation was 2.62%, 0.27%, 1.58%, respectively). The second period (6–12 months) was similar in all three groups, revealing a further steady (~ 1.4%) BMD decline. Conclusions Our results are consistent with previous findings that LSG negatively impacts BMD, stressing the importance of bone health-oriented measures in postoperative care. Moreover, the impact that seems more significant in males warrants future exploration, as it might change clinical practice. Graphical abstract

show abstract

Section: Discussionmentioning

confidence: 99%

Bone Mineral Density Trends During the First Year After Laparoscopic Sleeve Gastrectomy—a Cohort Study on 241 Patients

et al. 2021

View full text Add to dashboard Cite

show abstract

“…C. Cipriani cristiana.cipriani@gmail.com 1 Dipartimento di Scienze Cliniche, Internistiche, Anestesiologiche e Cardiovascolari, Sapienza Università di Roma, Roma, Italia Le evidenze cliniche e sperimentali hanno dimostrato come nell'ambito dell'interazione reciproca tra i due sistemi si configuri un dato ormai ben noto anche nella pratica clinica, quello della fragilità scheletrica associata a condizioni quali l'obesità, il diabete mellito tipo 2 e la sindrome metabolica [2].…”

unclassified

“…I meccanismi di interazione tra osso e tessuto adiposo sono differenti e coinvolgono vari sistemi endocrinometabolici. Tra di essi, è importante ricordare l'azione di leptina e adiponectina, visfatina, così come dell'asse vitamina D-paratormone (PTH), dell'insulina, di fattori di natura citochinica e di altri prodotti dal sistema monocitomacrofagico [2,3]. Infine, recenti evidenze hanno dimostrato come l'interazione tra osso e tessuto adiposo sia particolarmente evidente nel midollo osseo [1].…”

unclassified

“…Tali cellule sono componenti chiave di questo microambiente, così come le cellule staminali ematopoietiche e le mesenchymal stem cells del midollo osseo (bone marrow mesenchymal stem cells, BM-MSC). Queste ultime, infatti, possono differenziarsi verso la linea adipocitaria o quella osteoblastica, in accordo con fini meccanismi di regolazione [2]. Vi sono diverse condizioni cliniche nelle quali è stato descritto come l'alterazione di tali meccanismi favorisca la differenziazione in senso adipocitario a danno dell'osteoblastogenesi e sia associata a fragilità scheletrica [2].…”

unclassified

“…Queste ultime, infatti, possono differenziarsi verso la linea adipocitaria o quella osteoblastica, in accordo con fini meccanismi di regolazione [2]. Vi sono diverse condizioni cliniche nelle quali è stato descritto come l'alterazione di tali meccanismi favorisca la differenziazione in senso adipocitario a danno dell'osteoblastogenesi e sia associata a fragilità scheletrica [2].…”

unclassified

See 2 more Smart Citations

Adiposità dell’osso e fragilità scheletrica

Cipriani

2021

L'Endocrinologo

View full text Add to dashboard Cite

SommarioNell’ambito del reciproco cross-talk tra metabolismo osseo e tessuto adiposo, lo studio del tessuto adiposo midollare (BMAT) è uno degli spunti di ricerca più interessanti degli ultimi anni. Un aumento del BMAT è descritto in diverse condizioni cliniche, in cui vi è una correlazione inversa tra BMAT, densità minerale ossea e qualità dell’osso. Nella presente rassegna vengono riassunti i dati sperimentali e clinici più recenti circa l’interrelazione tra danno scheletrico e aumento del BMAT.

show abstract

Adipogenic progenitors in different organs: Pathophysiological implications

Favaretto

Bettini

Busetto

et al. 2021

Rev Endocr Metab Disord

View full text Add to dashboard Cite

In physiological conditions, the adipose organ resides in well-defined areas, where it acts providing an energy supply and as an endocrine organ involved in the control of whole-body energy metabolism. Adipose tissue adipokines connect the body’s nutritional status to the regulation of energy balance. When it surrounds organs, it provides also for mechanical protection. Adipose tissue has a complex and heterogenous cellular composition that includes adipocytes, adipose tissue-derived stromal and stem cells (ASCs) which are mesenchymal stromal cells, and endothelial and immune cells, which signal to each other and to other tissues to maintain homeostasis. In obesity and in other nutrition related diseases, as well as in age-related diseases, biological and functional changes of adipose tissue give rise to several complications. Obesity triggers alterations of ASCs, impairing adipose tissue remodeling and adipose tissue function, which induces low-grade systemic inflammation, progressive insulin resistance and other metabolic disorders. Adipose tissue grows by hyperplasia recruiting new ASCs and by hypertrophy, up to its expandability limit. To overcome this limitation and to store the excess of nutrients, adipose tissue develops ectopically, involving organs such as muscle, bone marrow and the heart. The origin of ectopic adipose organ is not clearly elucidated, and a possible explanation lies in the stimulation of the adipogenic differentiation of mesenchymal precursor cells which normally differentiate toward a lineage specific for the organ in which they reside. The chronic exposition of these newly-formed adipose depots to the pathological environment, will confer to them all the phenotypic characteristics of a dysfunctional adipose tissue, perpetuating the organ alterations. Visceral fat, but also ectopic fat, either in the liver, muscle or heart, can increase the risk of developing insulin resistance, type 2 diabetes, and cardiovascular diseases. Being able to prevent and to target dysfunctional adipose tissue will avoid the progression towards the complications of obesity and other nutrition-related diseases. The aim of this review is to summarize some of the knowledge regarding the presence of adipose tissue in particular tissues (where it is not usually present), describing the composition of its adipogenic precursors, and the interactions responsible for the development of organ pathologies.

show abstract

Obesity and Bone Health: A Complex Link

Cited by 77 publications

References 214 publications

Bone Mineral Density Trends During the First Year After Laparoscopic Sleeve Gastrectomy—a Cohort Study on 241 Patients

Bone Mineral Density Trends During the First Year After Laparoscopic Sleeve Gastrectomy—a Cohort Study on 241 Patients

Adiposità dell’osso e fragilità scheletrica

Adipogenic progenitors in different organs: Pathophysiological implications

Contact Info

Product

Resources

About