2021
DOI: 10.20945/2359-3997000000368 View full text |Buy / Rent full text
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Abstract: Objective: Adipose tissue-derived stromal/stem cells (ASCs) and vitamin D have immunomodulatory actions that could be useful for type 1 diabetes (T1D). We aimed in this study to investigate the safety and efficacy of ASCs + daily cholecalciferol (VIT D) for 6 months in patients with recent-onset T1D. Materials and methods: In this prospective, dual-center, open trial, patients with recent onset T1D received one dose of allogenic ASC (1 x 10 6 cells/kg) and cholecalciferol 2,000 UI/day for 6 months (group 1). T… Show more

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“…Similar results were obtained in the studies of Araujo et al [ 102 ] and Dantas et al [ 103 ], where a single dose of adipose-derived MSC infusion were combined with daily 2000 IU vitamin D 3 supplementation. Compared to control subjects on traditional treatment, improved HbA 1C levels and reduced insulin doses have been found 3-mo after MSC infusion[ 102 ], while basal C-peptide levels remained the same at first but significantly improved for the 6-mo follow-up measurement[ 102 , 103 ]. It has to be mentioned though that most patients reported transient headache and local reactions, and further mild but resolving adverse events were also reported by a significant amount of the study population.…”
Section: Mesenchymal Stem Cell Therapy In T1dmsupporting
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“…Similar results were obtained in the studies of Araujo et al [ 102 ] and Dantas et al [ 103 ], where a single dose of adipose-derived MSC infusion were combined with daily 2000 IU vitamin D 3 supplementation. Compared to control subjects on traditional treatment, improved HbA 1C levels and reduced insulin doses have been found 3-mo after MSC infusion[ 102 ], while basal C-peptide levels remained the same at first but significantly improved for the 6-mo follow-up measurement[ 102 , 103 ]. It has to be mentioned though that most patients reported transient headache and local reactions, and further mild but resolving adverse events were also reported by a significant amount of the study population.…”
Section: Mesenchymal Stem Cell Therapy In T1dmsupporting
“…We have previously reported a comparison between our patients and individuals that used only VIT D supplementation for 6 months and took part in a previous study. The CP AUC could not be compared since this group had only basal e peak CP, but ASC + VIT D had an increase in basal CP and a better HbA1c after 6 months when compared to VIT D supplementation group and controls (59). VIT D can act in lymphocyte proliferation, cellular autoimmune pathways and stimulated T regulatory response (19,20).…”
Section: Discussionmentioning
“…In a recent pilot study, patients with T1DM were administered by one dose of 1 × 10 6 /kg allogenic adipose tissue-derived stromal/stem cells (ASCs) and cholecalciferol 2000 UI/day for 6 months and compared with controls [ 56 ]. The authors declared that the glycosylated hemoglobin (HbA1C) values were noticeably improved without a remarkable elevation in insulin dose/kg that might be followed by the up-regulation in basal insulin release reported in those patients.…”
Section: Mesenchymal Stem Cellmentioning