Adipose tissue-derived cytokines and their correlations with clinical characteristics in Vietnamese patients with type 2 diabetes mellitus

Toàn, Nguyễn Lĩnh; Hoan, Nguyen Van; Cuong, Doan Viet; Dung, Nguyen Viet; Hang, Ngo Thu; Dieu, D.; Chung, Dang Thanh; Sơn, Hồ Anh; Phong, Phạm Xuân; Lenon, George Binh; De, Doan Van; Tong, Hoang Van

doi:10.1186/s13098-018-0343-4

Cited by 12 publications

(6 citation statements)

References 50 publications

(62 reference statements)

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“…29 The high positive correlation of fasting glucose with resistin was observed in the investigated non-MetS elderly participants, whereas in those elderly with diagnosed MetS average positive correlation was found for resistin and lipids traits. While, Thoan et al 30 found weak negative correlation for resistin and fasting glucose and resistin and triglycerides in overweight and type 2 diabetes patients.…”

Section: Discussionmentioning

confidence: 93%

The role of oxidant-antioxidant markers and resistin in metabolic syndrome elderly individuals

et al. 2021

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In elderly, hormones and oxidant-antioxidant interplay are suggested to mediate biochemical balance between adipose tissue to other tissues. Thus the study attempts to explore metabolic traits, plasma resistin, and oxidant-antioxidant markers in metabolic syndrome (MetS) in comparison to non-metabolic syndrome (non-MetS) elderly individuals. A total of 541 healthy elderly Caucasians, with no acute and/or chronic disorders were invited. After taking into account inclusion/exclusion criteria’s the MetS was defined as the presence of three out of ﬁve abnormal ﬁndings and allowed to divided groups into: non-metabolic syndrome, non-MetS ( n = 25, median age 69.0 years), and newly diagnosed MetS ( n = 29; median age 70.5 years) individuals. Glucose, plasma lipids, resistin (Res), thiobarbituric acid-reacting substances (TBARS), total antioxidant status (TAS), and Cu,Zn-superoxide dismutase (SOD-1) were measured. The MetS had higher resistin than non-MetS ( p < 0.04). The linear correlation (all at p < 0.05) showed correlation for Res&triacylglycerols ( R = 0.44), and for Res&diastolic blood pressure ( R = −0.58) and for SOD-1&fasting glucose ( R = −0.34) in MetS, while in the non-MetS group fasting glucose correlates with Res ( R = 0.58) and with TAS ( R = −0.43). The multiple regression analysis (alone and in combination) showed that independently from other factors resistin correlated positively with fasting glucose (β = 0.37; R = 0.58; R 2 = 0.23; p < 0.01) in all investigated elderly participants. In the MetS resistin correlated negatively with diastolic blood pressure (β = −0.68; R = 0.80; R 2 = 0.53; p = 0.0004) moreover in that group TAS correlated negatively with HDL-C (β = −0.71; R = 0.72; R 2 = 0.37; p = 0.01). While age correlated negatively with systolic blood pressure (β = −0.60; R = 0.62; R 2 = 0.14; p = 0.03) independently from other factors in the non-MetS group. Various metabolic factors contribute to maintain serum resistin and oxidant-antioxidant balance in the elderly people in the presence or absence of MetS. Resistin may serve as a predictor of MetS in the elderly, while strong antioxidant defense interactions in older individuals may indicate good health.

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Section: Discussionmentioning

confidence: 93%

The role of oxidant-antioxidant markers and resistin in metabolic syndrome elderly individuals

et al. 2021

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“…In a series of clinical cases the analysis of circulating SFRP5 levels in T2DM patients lead to an opposite conclusion. Data showed that circulating SFRP5 level is significantly lower in obese, diabetic and adult latent autoimmune diabetes patients compared to normal subjects, and is negatively correlated with BMI, waist circumference, fasting blood glucose, glycosylated hemoglobin, insulin level and IR index, supporting the role of SFRP5 as a protective factor in the pathogenesis of diabetes (121)(122)(123)(124)(125)(126). To the contrary, Canville et al reported that the plasma level of SFRP5 was higher in newly diagnosed T2DM patients compared to pre-diabetic or normal subjects, suggesting SFRP5 is an independent risk factor for T2DM (127).…”

Section: Diabetes and Irmentioning

confidence: 89%

Secreted Frizzled Related Proteins in Cardiovascular and Metabolic Diseases

et al. 2021

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Abnormal gene expression and secreted protein levels are accompanied by extensive pathological changes. Secreted frizzled related protein (SFRP) family members are antagonistic inhibitors of the Wnt signaling pathway, and they were recently found to be involved in the pathogenesis of a variety of metabolic diseases, which has led to extensive interest in SFRPs. Previous reports highlighted the importance of SFRPs in lipid metabolism, obesity, type 2 diabetes mellitus and cardiovascular diseases. In this review, we provide a detailed introduction of SFRPs, including their structural characteristics, receptors, inhibitors, signaling pathways and metabolic disease impacts. In addition to summarizing the pathologies and potential molecular mechanisms associated with SFRPs, this review further suggests the potential future use of SFRPs as disease biomarkers therapeutic targets.

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“…In another case-controlled study in overweight patients with diabetes, visfatin, leptin, resistin, monocyte chemoattractive protein-1, and retinol-binding protein 4 were evaluated. Visfatin was associated with higher HbA1c and HOMA-β levels[ 34 ]. Visfatin has been evaluated in the pathogenesis of diabetic nephropathy.…”

Section: Discussionmentioning

confidence: 99%

Relationship between diabetic polyneuropathy, serum visfatin, and oxidative stress biomarkers

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Karaaslan

et al. 2020

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BACKGROUND Diabetic polyneuropathy is a very common complication of diabetes. Numerous studies are available in terms of pathogenesis. But examination methods with low reliability are still not standardized and generally time consuming. High-sensitive, easy-to-access methods are expected. Biochemical markers are one of the subjects of research. We aimed to discover a potential biomarker that can be used for this purpose in patients with diabetes who have not yet developed symptoms of neuropathy. AIM To determine the place and availability of visfatin and thiol-disulfide homeostasis in this disorder. METHODS A total of 392 patients with type 2 diabetes mellitus were included in the study. The polyneuropathy clinical signs were evaluated with the Subjective Peripheral Neuropathy Screen Questionnaire and Michigan Neuropathy Screening Instrument questionnaire and examination. The biochemical parameters, oxidative stress markers, visfatin, and thiol-disulfide homeostasis were analyzed and correlated with each other and clinical signs. RESULTS Subjective Peripheral Neuropathy Screen Questionnaire and Michigan Neuropathy Screening Instrument questionnaire with examination scores were correlated with each other and diabetes duration ( P < 0.005). Neuropathy related symptoms were present in 20.7% of the patients, but neuropathy related findings were observed in 43.9% of the patients. Serum glucose, glycated hemoglobin, and visfatin were positively correlated with each other. Also, these parameters were positively correlated with the total oxidative stress index. Total and native thiol was positively correlated with total antioxidant status and negatively with oxidant status. Inversely thiol-disulfide positively correlated with higher glucose and oxidant status and negatively with total antioxidant status ( P < 0.005). There was no correlation between visfatin and thiol-disulphide ( P = 0.092, r = 0.086). However, a significant negative correlation was observed between visfatin and total with native thiol ( P < 0.005, r = -0.338), ( P < 0.005, r = -0.448). CONCLUSION Diagnosis of neuropathy is one of the issues studied in patients with diabetes. Visfatin and thiol-disulfide balance were analyzed for the first time in this study with inspiring results.

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Adipose tissue-derived cytokines and their correlations with clinical characteristics in Vietnamese patients with type 2 diabetes mellitus

Cited by 12 publications

References 50 publications

The role of oxidant-antioxidant markers and resistin in metabolic syndrome elderly individuals

The role of oxidant-antioxidant markers and resistin in metabolic syndrome elderly individuals

Secreted Frizzled Related Proteins in Cardiovascular and Metabolic Diseases

Relationship between diabetic polyneuropathy, serum visfatin, and oxidative stress biomarkers

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