Relationship between diabetic polyneuropathy, serum visfatin, and oxidative stress biomarkers

Abstract

BACKGROUND Diabetic polyneuropathy is a very common complication of diabetes. Numerous studies are available in terms of pathogenesis. But examination methods with low reliability are still not standardized and generally time consuming. High-sensitive, easy-to-access methods are expected. Biochemical markers are one of the subjects of research. We aimed to discover a potential biomarker that can be used for this purpose in patients with diabetes who have not yet developed symptoms of neuropathy. AIM To determine the place and availability of visfatin and thiol-disulfide homeostasis in this disorder. METHODS A total of 392 patients with type 2 diabetes mellitus were included in the study. The polyneuropathy clinical signs were evaluated with the Subjective Peripheral Neuropathy Screen Questionnaire and Michigan Neuropathy Screening Instrument questionnaire and examination. The biochemical parameters, oxidative stress markers, visfatin, and thiol-disulfide homeostasis were analyzed and correlated with each other and clinical signs. RESULTS Subjective Peripheral Neuropathy Screen Questionnaire and Michigan Neuropathy Screening Instrument questionnaire with examination scores were correlated with each other and diabetes duration ( P < 0.005). Neuropathy related symptoms were present in 20.7% of the patients, but neuropathy related findings were observed in 43.9% of the patients. Serum glucose, glycated hemoglobin, and visfatin were positively correlated with each other. Also, these parameters were positively correlated with the total oxidative stress index. Total and native thiol was positively correlated with total antioxidant status and negatively with oxidant status. Inversely thiol-disulfide positively correlated with higher glucose and oxidant status and negatively with total antioxidant status ( P < 0.005). There was no correlation between visfatin and thiol-disulphide ( P = 0.092, r = 0.086). However, a significant negative correlation was observed between visfatin and total with native thiol ( P < 0.005, r = -0.338), ( P < 0.005, r = -0.448). CONCLUSION Diagnosis of neuropathy is one of the issues studied in patients with diabetes. Visfatin and thiol-disulfide balance were analyzed for the first time in this study with inspiring results.

Determination of Visfatin Level in Patients with Diabetes and Peripheral Neuropathy as Early Predicted Factor

“…Encamps are considered to provide a way for organs to communicate [35]. Previous research by Buyukaydin et al [36] revealed no relations hip between Visfatin results and biochemical parameters, oxidative stress biomarkers, or thioldisulphide levels. Visfatin may be implicated in endothelial dysfunction, according to Alghasham and Barakat [37].…”

Role of visfatin in obesity-induced insulin resistance

“…NAD is required for various processes, including metabolic processes, glucose-stimulated insulin secretion, cell survival, cell cycle control, and apoptosis[ 51 ]. However, elevated levels of visfatin have been linked to increased levels of inflammatory markers such as IL-6, IL-8, C-reactive protein, and monocyte chemotactic protein-1[ 52 , 53 ], endothelial dysfunction[ 54 ], and increase in oxidative stress[ 55 - 58 ]. These findings point to the existence of an average physiological level of visfatin at which it is properly controlled and fulfils its physiological functions, as well as a threshold level at which its pathological consequences occur.…”

Genetic and Epigenomic Modifiers of Diabetic Neuropathy

“…The role of oxidative stress in pathogenesis of DN was broadly evaluated previously. Increased ROS is considered as one of the factors associated with programmed cell death [ 39 ]. This is of particular importance sine ROS were observed in dorsal root ganglia and Schwann cells; thus they might play important role in the DN pathogenesis [ 39 ].…”

“…Increased ROS is considered as one of the factors associated with programmed cell death [ 39 ]. This is of particular importance sine ROS were observed in dorsal root ganglia and Schwann cells; thus they might play important role in the DN pathogenesis [ 39 ]. Additionally, the oxidative stress affects the mitochondria via several mechanisms that include inhibition of ATP synthesis as well as essential proteins in to mitochondria, and affects mitochondrial membrane permeability by damaging the inner membrane proteins [ 38 ].…”