Adiponectin and Insulin Resistance in Childhood Obesity

Panagopoulou, Paraskevi; Galli-Tsinopoulou, Assimina; Fleva, Alexandra; Pavlitou-Tsiontsi, Ekaterini; Vavatsi-Christaki, Norma; Nousia-Arvanitakis, Sanda

doi:10.1097/mpg.0b013e31817fcb67

Cited by 40 publications

(36 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We found lower adiponectin levels in our patients and this is consistent with previous studies [4,33]. Previous studies suggest that hypoadiponectinemia might be involved in the development of FLD [4,24]. In our study, adiponectin levels were negatively correlated with the presence of FLD detected by the two methods.…”

Section: Discussionsupporting

confidence: 95%

Metabolic predictors for early identification of fatty liver using doppler and B-mode ultrasonography in overweight and obese adolescents

et al. 2010

View full text Add to dashboard Cite

(1) to evaluate the frequency of asymptomatic fatty liver disease (FLD) using both Doppler and B-mode ultrasound (US) in overweight and obese adolescents; (2) to compare metabolic findings of fatty liver (FL) assessed by two methods; and (3) to evaluate metabolic predictors of FL shown by these methods. Fifty-nine overweight and obese adolescents aged between 9.0 and 17.0 years and 41 non-obese healthy adolescents were included in this study. B-mode and right hepatic vein Doppler ultrasonography (US) were performed and anthropometric indices, lipid profiles, and adiponectin levels were evaluated in all adolescents. HDL-C levels were significantly lower in patients with FL detected by Doppler US compared to patients without FL (p < 0.05). HDL-C levels were inversely correlated with presence of FL assessed by two methods (r = -0.285, p = 0.004; r = -0.328, p = 0.001, respectively) and adiponectin levels were correlated with presence of FL only detected by B-mode US (r = -0.263, p = 0.008). Adiponectin levels were significantly lower in patients with FL than those without FL assessed by B-Mode US (p = 0.049). Multiple regression analysis revealed that HDL-C levels was the most important predictor of FL assessed by Doppler US (p = 0.027), while body mass index was the determinant of FL assessed by two methods (p < 0.001) in asymptomatic overweight and obese adolescents. It was found that FLD, identified by both B-mode and Doppler US, is seen frequently in asymptomatic overweight and obese adolescents. Elevated BMI is associated with increased risk of FL assessed by two ultrasonographic methods. When using Doppler US, low HDL-C levels can be used as a good predictor for presence of FLD in overweight and obese adolescents.

show abstract

Section: Discussionsupporting

confidence: 95%

Metabolic predictors for early identification of fatty liver using doppler and B-mode ultrasonography in overweight and obese adolescents

et al. 2010

View full text Add to dashboard Cite

show abstract

“…[33][34][35][36][37] In our study, parallel to the literature, adiponectin levels were found to be significantly low in the obese and overweight groups compared with the control group. Although in our research, adiponectin levels were significantly lower in the cases with insulin resistance than in the cases without insulin resistance, no significant correlations were found between adiponectin and HOMA-IR in the obese, overweight and control groups.…”

Section: Discussionsupporting

confidence: 81%

Association of cardiac changes with serum adiponectin and resistin levels in obese and overweight children

Aknc

Karakurt

Gurbuz

et al. 2013

Journal of Cardiovascular Medicine

View full text Add to dashboard Cite

show abstract

“…A number of studies have addressed the relationship between insulin resistance and adiponectin in obese children and adolescents [15,16,17]. However, there are only a few studies about the correlation between adiponectin levels and family history of T2DM in children and adolescents [18].…”

Section: Introductionmentioning

confidence: 99%

Low Serum Adiponectin Levels in Korean Children with a Family History of Type 2 Diabetes Mellitus

Nam²,

Rhie³

et al. 2012

Horm Res Paediatr

View full text Add to dashboard Cite

Background/Aims: The current worldwide increases of type 2 diabetes mellitus (T2DM) in children coincide with increases in the prevalence of obesity. We investigated the insulin resistance and adiponectin levels of children and adolescents with a family history of T2DM (FHD). Methods: Our sample included 131 children and adolescents aged 8–15 years. Fasting plasma glucose, lipids, fasting insulin, adiponectin levels and HOMA-IR were analyzed according to FHD and obesity. Oral glucose tolerance tests were performed in all subjects except non-obese subjects without FHD. Results: Adiponectin levels of subjects with FHD were significantly lower than those of subjects without FHD in both the obese and nonobese groups. HOMA-IR was significantly higher in obese subjects with FHD than in those without FHD. Adiponectin levels were found to be independently associated with FHD and Matsuda index. The frequency of impaired glucose tolerance in obese subjects with FHD was more than four times higher compared to obese subjects without FHD. Conclusion: Our results suggest that FHD could be a risk factor of T2DM in obese Korean children, especially with low serum levels of adiponectin.

show abstract

Adiponectin and Insulin Resistance in Childhood Obesity

Cited by 40 publications

References 34 publications

Metabolic predictors for early identification of fatty liver using doppler and B-mode ultrasonography in overweight and obese adolescents

Metabolic predictors for early identification of fatty liver using doppler and B-mode ultrasonography in overweight and obese adolescents

Association of cardiac changes with serum adiponectin and resistin levels in obese and overweight children

Low Serum Adiponectin Levels in Korean Children with a Family History of Type 2 Diabetes Mellitus

Contact Info

Product

Resources

About