Association of cardiac changes with serum adiponectin and resistin levels in obese and overweight children

Aknc, Ayşehan; Karakurt, Cemşit; Gurbuz, Sibel; Elkran, Ozlem; Nalbantoğlu, Özlem; Koçak, Gülendam; Güldür, Tayfun; Yoloğlu, Saim

doi:10.2459/jcm.0b013e328351674e

Cited by 10 publications

(6 citation statements)

References 46 publications

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“…However, the mechanisms that account for the ability of resistin to predict human heart failure are unclear. In this regard, although associations between circulating resistin concentrations and left ventricular mass (LVM) have been demonstrated in a small study sample of children [17], no independent relations were noted in large adult population samples [18,19]. Further, in large samples only modest independent relations between circulating resistin concentrations and LV systolic function were reported [18,19].…”

Section: Introductionmentioning

confidence: 89%

Independent associations between resistin and left ventricular mass and myocardial dysfunction in a community sample with prevalent obesity

Norman

Norton

Libhaber

et al. 2015

International Journal of Cardiology

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Section: Introductionmentioning

confidence: 89%

Independent associations between resistin and left ventricular mass and myocardial dysfunction in a community sample with prevalent obesity

Norman

Norton

Libhaber

et al. 2015

International Journal of Cardiology

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“…Current commercial assays offer the measurement of medium molecular weight adiponectin (MMW), and total adioponectin (Total). HMW has been shown to predict future weight gain [Hivert et al, ] and the ratio of HMW to Total has been found to be associated with obesity in children [Aknc et al, ]. However, it is unclear in some conditions such as coronary atherosclerosis whether HMW or the ratio of HMW/Total adiponectin provides the more accurate prediction of metabolic condition [Liang et al, ].…”

Section: Introductionmentioning

confidence: 99%

Development of Metabolic Function Biomarkers in the Common Marmoset, Callithrix jacchus

Ziegler

Colman

Tardif

et al. 2013

American J Primatol

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Metabolic assessment of a nonhuman primate model of metabolic syndrome and obesity requires the necessary biomarkers specific to the species. While the rhesus monkey has a number of specific assays for assessing metabolic syndrome, the marmoset does not. Furthermore, the common marmoset (Callithrix jacchus) has a small blood volume that necessitates using a single blood volume for multiple analyses. The common marmoset holds a great potential as an alternative primate model for the study of human disease but assay methods need to be developed and validated for the biomarkers of metabolic syndrome. Here we report on the adaptation, development and validation of commercially available immunoassays for common marmoset samples in small volumes. We have performed biological validations for insulin, adiponectin, leptin, and ghrelin to demonstrate the use of these biomarkers in examining metabolic syndrome and other related diseases in the common marmoset.

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“…Low birth weight has previously been linked with high leptin and low adiponectin levels [ 59 ]. However, some studies have reported inconsistent findings regarding resistin in relation to low perinatal weight and obesity or overweight [ 59 , 60 , 61 , 62 ]. Therefore, the role of this adipokine in regulating insulin sensitivity and adipogenesis during the perinatal period is not yet fully understood [ 63 ].…”

Section: Discussionmentioning

confidence: 99%

Metabolic and Low-Grade Inflammation Risk in Young Adults with a History of Extrauterine Growth Restriction

Palomino-Fernández,

Pastor-Villaescusa,

Velasco

et al. 2024

Nutrients

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Children with a history of extrauterine growth restriction (EUGR), later at prepubertal age, exhibit an increased metabolic risk including risen insulin resistance and low-grade inflammation. However, the progression of such metabolic changes after puberty and the lasting health implications have not yet been investigated. The objective of this study was to ascertain whether young adults with a history of EUGR faced increased vulnerability to metabolic disorders. A study was conducted comparing a group of adults with a history of EUGR with a healthy reference group. A total of 110 young adults (36 from the EUGR group and 74 from the control group) were included. Anthropometric variables, blood pressure (BP), general biochemical parameters, plasma inflammatory biomarkers, and adipokines were assessed. Compared to the reference group, the EUGR group had a shorter height and body weight with higher lean mass and waist circumference, as well as a greater percentage of individuals with high BP. In addition, EUGR patients had higher values of insulin, HOMA-IR, nerve growth factor, and leptin, and lower levels of adiponectin and resistin. The present study suggests that young adults with a history of EUGR present increased metabolic risk factors therefore, clinical follow-up should be considered.

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Association of cardiac changes with serum adiponectin and resistin levels in obese and overweight children

Cited by 10 publications

References 46 publications

Independent associations between resistin and left ventricular mass and myocardial dysfunction in a community sample with prevalent obesity

Independent associations between resistin and left ventricular mass and myocardial dysfunction in a community sample with prevalent obesity

Development of Metabolic Function Biomarkers in the Common Marmoset, Callithrix jacchus

Metabolic and Low-Grade Inflammation Risk in Young Adults with a History of Extrauterine Growth Restriction

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