Low Serum Adiponectin Levels in Korean Children with a Family History of Type 2 Diabetes Mellitus

Abstract

Background/Aims: The current worldwide increases of type 2 diabetes mellitus (T2DM) in children coincide with increases in the prevalence of obesity. We investigated the insulin resistance and adiponectin levels of children and adolescents with a family history of T2DM (FHD). Methods: Our sample included 131 children and adolescents aged 8–15 years. Fasting plasma glucose, lipids, fasting insulin, adiponectin levels and HOMA-IR were analyzed according to FHD and obesity. Oral glucose tolerance tests were performed in all subjects except non-obese subjects without FHD. Results: Adiponectin levels of subjects with FHD were significantly lower than those of subjects without FHD in both the obese and nonobese groups. HOMA-IR was significantly higher in obese subjects with FHD than in those without FHD. Adiponectin levels were found to be independently associated with FHD and Matsuda index. The frequency of impaired glucose tolerance in obese subjects with FHD was more than four times higher compared to obese subjects without FHD. Conclusion: Our results suggest that FHD could be a risk factor of T2DM in obese Korean children, especially with low serum levels of adiponectin.

Serum and salivary adiponectin levels as predictive markers for diabetes mellitus in children with a family history of diabetes

“…However, this trend was not observed in children whose mothers or other relatives had a history of DM. This disagrees with Joung et al [25], who reported that adiponectin concentrations were independently related to a family history of diabetes. This may be explained by the fact that children of diabetic parents often exhibit signs of excess body lipid as early as childhood, and the development of insulin resistance syndrome in childhood can accelerate into young adulthood [26].…”

Adiponectin, ALT and family history as critical markers for the development of type 2 diabetes in obese Japanese children

“…A family history of T2D was shown to be another important factor for the onset of T2D in obese Japanese children. Oh et al 24 showed that obese Korean children and adolescents with a family history of T2D were more insulin resistant and had lower serum adiponectin levels, compared with an obese group without a family history of T2D. Another study has also shown that a family history of T2D in white youths was associated with reduced insulin sensitivity 25 …”

Association of Adiponectin rs1501299 and rs266729 Gene Polymorphisms With Nonalcoholic Fatty Liver Disease

“…Adiponectin is produced by adipocytes, and then secreted in the circulation of human healthy individuals at relatively high levels, which fluctuates between 5 and 30 μg/ml (19). However, the levels of this adipokine is reduced in patients with insulin resistance (20), type II diabetes mellitus (T2DM) (21, 22), obesity (23), cardiovascular disease (24), metabolic syndrome (25), and NAFLD (26-29). …”