Adiponectin, ALT and family history as critical markers for the development of type 2 diabetes in obese Japanese children

Yasuda, Yuki; Miyake, Nobuka; Matsuoka, Hisafumi; Sugihara, Shigetaka

doi:10.1002/edm2.178

Cited by 11 publications

(10 citation statements)

References 23 publications

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“…The association of obesity and low adiponectin level suggested the possibility of adiponectin acting as a biomarker for metabolic syndrome, especially among perimenopausal and postmenopausal women or the elderly [78,79]. Low adiponectin levels were found in obese children with diabetes [80], and a polymorphism of the adiponectin gene resulting in a low adiponectin level was associated with diabetes [81]. Homeostatic model assessment (HOMA) including adiponectin level showed better prediction for metabolic syndrome than HOMA insulin resistance itself [82].…”

Section: Clinical Studiesmentioning

confidence: 99%

The Roles and Associated Mechanisms of Adipokines in Development of Metabolic Syndrome

Kim

et al. 2022

Molecules

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Metabolic syndrome is a cluster of metabolic indicators that increase the risk of diabetes and cardiovascular diseases. Visceral obesity and factors derived from altered adipose tissue, adipokines, play critical roles in the development of metabolic syndrome. Although the adipokines leptin and adiponectin improve insulin sensitivity, others contribute to the development of glucose intolerance, including visfatin, fetuin-A, resistin, and plasminogen activator inhibitor-1 (PAI-1). Leptin and adiponectin increase fatty acid oxidation, prevent foam cell formation, and improve lipid metabolism, while visfatin, fetuin-A, PAI-1, and resistin have pro-atherogenic properties. In this review, we briefly summarize the role of various adipokines in the development of metabolic syndrome, focusing on glucose homeostasis and lipid metabolism.

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Section: Clinical Studiesmentioning

confidence: 99%

The Roles and Associated Mechanisms of Adipokines in Development of Metabolic Syndrome

Kim

et al. 2022

Molecules

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Section: Discussionmentioning

confidence: 99%

“…Studies in children on the possible association between liver-function enzymes and obesity-related diseases, such as metabolic syndrome and NAFLD, are limited but indicate the significant relationship between the activity of ALT and MetS components [ 13 , 14 ]. In obese Japanese children with MetS or type 2 diabetes (T2DM), ALT showed a very good discriminatory power for the onset of T2DM [ 14 ]. Another recent large European multicenter cross-sectional study which assessed the prevalence of prediabetes and T2DM in obese children, with varying degrees of elevated transaminases, showed much higher risk of prediabetes and T2DM if the increase in ALT activity was up to two-fold the upper reference limit [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Association between Fasting and Postprandial Levels of Liver Enzymes with Metabolic Syndrome and Suspected Prediabetes in Prepubertal Children

Bergmann

Stefańska

Krintus

et al. 2023

IJMS

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Elevated liver enzyme activity may be associated with metabolic syndrome (MetS); however, it is not included in the MetS definition for children. Postprandial changes in the levels of biochemistry tests are related to manifestations of metabolic abnormalities. We assessed the association between fasting and postprandial liver enzymes levels with MetS and elevated hemoglobin A1c (HbA1c) in children aged 9–11. The study included 51 girls and 48 boys, all presumably healthy. In all participants’ anthropometric indices, fasting glucose, insulin, lipid profile and HbA1c were measured. Enzymes, including alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT), were assayed in fasting and postprandial states. Individuals were divided into subgroups: with (MetS(+): n = 26); without MetS (MetS(−): n = 73); with HbA1c levels ≤ 5.3% (n = 39); and ≥5.7% (n = 11). Elevated fasting GGT levels were found in 23% of MetS(+) children and rarely in MetS(−) children; increased postprandial GGT was noted in 35% of MetS(+) individuals. Postprandial GGT changes tend to predict MetS (OR = 1.16; p = 0.092). Increased fasting ALT was found rarely in MetS(+) children, but did not occur in MetS(−) children. HbA1c ≥ 5.7% occurred rarely and neither fasting ALT nor GGT were related to elevated HbA1c. However, postprandial change of ALT was a good positive predictor of increased HbA1c (OR = 1.33; p = 0.021). Postprandial GGT performs better as an indicator of metabolic syndrome occurrence, and instead postprandial ALT may predict prediabetes in prepubertal children.

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“…These results are inconsistent with those of previous studies. 9 , 25 Nielsen et al observed 756,219 individuals and found a 1 μg/mL low plasma adiponectin was associated with an increased risk of T2D. 9 Yasuda et al identified 107 obese children and found plasma adiponectin levels in T2D group are significantly lower than those of the metabolic syndrome and healthy groups.…”

Section: Discussionmentioning

confidence: 99%

Associations between the levels of circulating inflammatory adipokines and the risk of type 2 diabetes in Chinese male individuals: A case–control study

Sun

Qiu

et al. 2023

Clinical Laboratory Analysis

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Background Whether the levels of circulating inflammatory adipokines affect the progression of type 2 diabetes (T2D) remains unclear. This study aimed to assess the association between circulating inflammatory adipokine levels and risk of T2D. Methods This case–control study involved 130 individuals consisting of 66 healthy controls (Control group) and 64 patients with T2D (T2D group) in Lishui Municipal Central Hospital from January 2017 to June 2017. Multivariate logistic regression analysis was applied to assess the associations between circulating inflammatory adipokine levels and the risk of T2D. Results There were significant differences in the levels of adiponectin ( p = 0.013) and visfatin ( p < 0.001) between the T2D and Control groups. In contrast, no significant differences in leptin ( p = 0.113), TNF‐α ( p = 0.632), and IL‐6 ( p = 0.156) levels were found between the groups. Multivariate logistic regression indicated that elevated visfatin level was associated with an increased risk of T2D (OR: 3.543; 95% CI: 1.771–7.088; p < 0.001), while adiponectin (OR: 1.946; 95% CI: 0.925–4.094; p = 0.079), leptin (OR: 3.723; 95% CI: 0.788–17.583; p = 0.097), TNF‐α (OR: 1.081; 95% CI: 0.911–1.281; p = 0.373), and IL‐6 (OR: 0.878; 95% CI: 0.657–1.173; p = 0.379) were not associated with the risk of T2D. Conclusions This study found elevated visfatin levels are associated with an increased risk of T2D, while adiponectin, leptin, TNF‐α, and IL‐6 are not. These findings should be further verified by a large‐scale prospective study.

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Adiponectin, ALT and family history as critical markers for the development of type 2 diabetes in obese Japanese children

Cited by 11 publications

References 23 publications

The Roles and Associated Mechanisms of Adipokines in Development of Metabolic Syndrome

The Roles and Associated Mechanisms of Adipokines in Development of Metabolic Syndrome

Association between Fasting and Postprandial Levels of Liver Enzymes with Metabolic Syndrome and Suspected Prediabetes in Prepubertal Children

Associations between the levels of circulating inflammatory adipokines and the risk of type 2 diabetes in Chinese male individuals: A case–control study

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