Adipokines Level in Metabolically Healthy Obese Saint-Petersburg Inhabitants (ESSE-RF)

Boyarinova, M.; Av, Orlov; Op, Rotar; As, Alieva; Ev, Moguchaya; Eu, Vasileva; Vn, Soltsev; Ei, Baranova; Ao, Konradi

doi:10.18565/cardio.2016.8.40-45

Cited by 11 publications

(11 citation statements)

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“…The identified correlations between QI and leptin (positive) and adiponectin (inverse) in Group 1 can be considered taking into account the data on the dependence of adipokin level on body weight [27]. The associations of QI with IL-6, IL-10, IFN-γ in Group 2 and with IL-4 in Group 3 confirm the literature data on the pathogenetic significance of adipose tissue in the development of asthma [10,28].…”

Section: The Interrelations Between Body Mass Index Levels Of Pro-supporting

confidence: 73%

Features of cytokine and adipokine regulation in asthma associated with obesity

Yurenko¹,

Аntonyuk²,

Mineeva³

et al. 2019

Russ Open Med J

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The aim is to establish interrelations between levels of cytokines and adipokines in blood serum of patients with asthma; to reveal the features of cytokine and adipokine regulation in asthma associated with obesity. Material and Methods -We examined 71 patients with partially controlled mild asthma: 24 normal-weight patients (group 1), 24 overweight patients (group 2), 23 patients with grade I and II obesity (group 3). The control group consisted of 25 healthy volunteers. Blood serum levels of Tumour necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), interleukin-2 (IL-2), IL-4, IL-6, IL-10, and IL-17A were studied by flow cytometry. The concentrations of leptin and adiponectin were measured by an enzyme immunoassay.Results -Increase levels of TNF-α, IL-6, IL-17A and IL-4 have been found in asthma patients regardless of body weight. At the same time, IL-6 level in the groups 2 and 3 was 1.4 times higher than in group 1. IL-17A level in patients with asthma and obesity was 1.2 times higher than in the groups 1 and 2. The elevation of IL-10 level in 1.8 and 2.3 times in patients of groups 2 аnd 3 in comparison with the group 1, respectively, has been determined. Hyperleptinemia was detected in the groups 2 and 3. A positive correlation between the body mass index and the levels of leptin, IL-4, IL-6, IL-10, IFN-γ and an invert correlation between this index and adiponectin concentration has been established. The interrelations between the levels of leptin, pro-and anti-inflammatory cytokines, depending on the body weight, have been revealed. Conclusion -The production of pro-inflammatory cytokines IL-6 and IL-17A, as well as anti-inflammatory cytokine IL-10 enhances in asthma patients as the body weight increases and the obesity develops. The features of cytokine and adipokine imbalance indicate the prevalence of neutrophilic inflammation in asthma with obesity and demonstrates pathogenetic link between obesity and asthma.

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Section: The Interrelations Between Body Mass Index Levels Of Pro-supporting

confidence: 73%

Features of cytokine and adipokine regulation in asthma associated with obesity

Yurenko¹,

Аntonyuk²,

Mineeva³

et al. 2019

Russ Open Med J

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“…Hypoadiponectin is a risk factor for atherosclerosis and type 2 diabetes because it promotes the pathological reaction and insulin resistance of the cardiovascular system ( Jamar et al, 2017 ). In MHO, low adiponectin level is an important way to endanger health ( Martinez-Larrad et al, 2014 ; Boyarinova et al, 2016 ).…”

Section: The Micro Metabolic Characteristics Of Metabolically Healthy...mentioning

confidence: 99%

The Harm of Metabolically Healthy Obese and the Effect of Exercise on Their Health Promotion

Pan

Hai-chun

2022

Front. Physiol.

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Obesity and obesity-related diseases [type 2 diabetes, cardiovascular disease (CVD), and cancer] are becoming more common, which is a major public health concern. Metabolically healthy obesity (MHO) has become a type of obesity, accounting for a large proportion of obese people. MHO is still harmful to health. It was discovered that MHO screening criteria could not well reflect health hazards, whereas visceral fat, adiponectin pathway, oxidative stress, chronic inflammation, and histological indicators at the microlevel could clearly distinguish MHO from health control, and the biological pathways involved in these micro indicators were related to MHO pathogenesis. This review reveals that MHO’s micro metabolic abnormality is the initial cause of the increase of disease risk in the future. Exploring the biological pathway of MHO is important in order to develop an effective mechanism-based preventive and treatment intervention strategy. Exercise can correct the abnormal micro metabolic pathway of MHO, regulate metabolic homeostasis, and enhance metabolic flexibility. It is a supplementary or possible alternative to the traditional healthcare prevention/treatment strategy as well as an important strategy for reducing MHO-related health hazards.

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“…However, some reports on the possible role of leptin, adiponectin, and resistin in MHO have indicated that higher leptin levels, leptin/adiponectin ratio, and lower adiponectin contribute to the increased risk of hypertension in MHO both in children and adolescents and elevated adiponectin level among obese women could be presumably provide a favorable metabolic profile [26,27]. A few studies have shown that circulating adipokines such as chemerin and retinol-binding protein-4 were significantly low in MHO subjects as compared to metabolically unhealthy obese (MUO) individuals [28].…”

Section: What Contributes To Mho?mentioning

confidence: 99%

The Answer to Why Some Are Obese but Healthy?!

Dv¹

2018

J Obes Chronic Dis

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Adipokines Level in Metabolically Healthy Obese Saint-Petersburg Inhabitants (ESSE-RF)

Cited by 11 publications

References 0 publications

Features of cytokine and adipokine regulation in asthma associated with obesity

Features of cytokine and adipokine regulation in asthma associated with obesity

The Harm of Metabolically Healthy Obese and the Effect of Exercise on Their Health Promotion

The Answer to Why Some Are Obese but Healthy?!

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