Features of cytokine and adipokine regulation in asthma associated with obesity

Yurenko, A. V.; Аntonyuk, M. V.; Mineeva, Elena E.; Новгородцева, Т. П.; Khodosova, K. K.

doi:10.15275/rusomj.2019.0203

Cited by 3 publications

(3 citation statements)

References 16 publications

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“…Assessment of methodological quality was performed on the 56 articles that met the review inclusion criteria, of which nine were excluded due to poor methodological quality (online supplemental table S3). 23–31 Reference lists of included studies were hand-searched. This process identified one additional article,32 which was also assessed for eligibility and methodological quality (figure 1).…”

Section: Resultsmentioning

confidence: 99%

Effect of obesity on airway and systemic inflammation in adults with asthma: a systematic review and meta-analysis

Scott

McLoughlin

et al. 2023

Thorax

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BackgroundObesity is associated with more severe asthma, however, the mechanisms responsible are poorly understood. Obesity is also associated with low-grade systemic inflammation; it is possible that this inflammation extends to the airways of adults with asthma, contributing to worse asthma outcomes. Accordingly, the aim of this review was to examine whether obesity is associated with increased airway and systemic inflammation and adipokines, in adults with asthma.MethodsMedline, Embase, CINAHL, Scopus and Current Contents were searched till 11 August 2021. Studies reporting measures of airway inflammation, systemic inflammation and/or adipokines in obese versus non-obese adults with asthma were assessed. We conducted random effects meta-analyses. We assessed heterogeneity using the I2statistic and publication bias using funnel plots.ResultsWe included 40 studies in the meta-analysis. Sputum neutrophils were 5% higher in obese versus non-obese asthmatics (mean difference (MD)=5.0%, 95% CI: 1.2 to 8.9, n=2297, p=0.01, I2=42%). Blood neutrophil count was also higher in obesity. There was no difference in sputum %eosinophils; however, bronchial submucosal eosinophil count (standardised mean difference (SMD)=0.58, 95% CI=0.25 to 0.91, p<0.001, n=181, I2=0%) and sputum interleukin 5 (IL-5) (SMD=0.46, 95% CI=0.17 to 0.75, p<0.002, n=198, I2=0%) were higher in obesity. Conversely, fractional exhaled nitric oxide was 4.5 ppb lower in obesity (MD=−4.5 ppb, 95% CI=−7.1 ppb to −1.8 ppb, p<0.001, n=2601, I2=40%). Blood C reactive protein, IL-6 and leptin were also higher in obesity.ConclusionsObese asthmatics have a different pattern of inflammation to non-obese asthmatics. Mechanistic studies examining the pattern of inflammation in obese asthmatics are warranted. Studies should also investigate the clinical relevance of this altered inflammatory response.PROSPERO registeration numberCRD42021254525.

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Section: Resultsmentioning

confidence: 99%

Effect of obesity on airway and systemic inflammation in adults with asthma: a systematic review and meta-analysis

Scott

McLoughlin

et al. 2023

Thorax

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“…Продукция IL-17А приводит к активации нейтрофилов и других антимикробных факторов и формированию аутоиммунного типа воспаления. Такая закономерность свидетельствует о наличии нейтрофильного типа воспаления у пациентов с БА, ассоциированной с ожирением [19].…”

Section: Discussionunclassified

“…При этом отмечается различный фенотип воспаления, в зависимости от массы тела, даже при легкой степени тяжести БА. В ранее проведенных авторами данной статьи исследованиях установлено, что у пациентов при БА легкой степени тяжести частично контролируемого течения при увеличении массы тела и развитии ожирения характер цитокинового дисбаланса свидетельствует о преобладании нейтрофильного типа воспаления [19]. Кроме того, при данном фенотипе БА поражаются не только центральные бронхи, но и МДП, а персистирующее воспаление является одним из факторов, препятствующих достижению контроля над заболеванием [4].…”

Section: воспаление и малые дыхательные путиunclassified

Pathophysiological relation between the systemic inflammation and the state of small airways in mild asthma with obesity

et al. 2022

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The aim of present study was to establish the relationship between the level of blood serum cytokines and indexes of pulmonary function as well as to identify the markers of evolving dysfunction of small airways in obese patients with partially controlled mild bronchial asthma. We have examined 53 patients with mild asthma of partially controlled clinical course complicated with obesity (I-II degree). The control group consisted of 25 healthy volunteers. All participants underwent spirometry, bodyplethysmography. Tumor necrosis factor alpha (TNFα), interferon gamma (IFNγ), interleukins (IL) IL2, IL-4, IL-6, IL-10, IL-17A were determined in blood serum. In the patients with partially controlled mild asthma, an increase in IL-17A by 55.8%, and IL-4 by 44.9% was detected, regardless of body mass. According to the results of cluster analysis, two sub-groups were discerned, depending on the state of the small airways and the levels of pro- and anti-inflammatory cytokines. The dysfunction of small airways was shown to be accompanied by hypercytokinemia being more common in bronchial asthma with predominant Th1-and Th17-immune responses. We have revealed an association between IL-17A, IL-6 levels and functional indices reflecting the state of the small airways, as well as correlation between IFNγ and the indices of bronchial obstruction. The features of pulmonary function were found to be dependent on the cytokine status in mild asthma with obesity. Two immuno-functional variants were identified, differing in activity of systemic inflammation, type of immune response, and functional state of the small airways. The revealed relationships allow us to consider IL-17A, IL-6 and IFNγ as markers of small airways dysfunction in mild asthma of partially controlled clinical course associated with obesity.

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The role of fatty acids and lipid inflammatory mediators in the development of small airway dysfunction in asthma complicated with obesity

Yurenko

Новгородцева

Denisenko

et al. 2023

Acta biomedica scientifica

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Background. Small airway involvement is important in determining the phenotypes of bronchial asthma. Establishing the mechanisms of dysfunction of small airways will make it possible to predict the course and control bronchial asthma.The aim. To study the relationship between the modification of the composition of fatty acids, lipid inflammatory mediators (eicosanoids, plasmalogens) and the functional state of small airways and to identify lipid biomarkers for the development of small airway dysfunction in bronchial asthma associated with obesity.Materials and methods. The study included 85 patients with mild, partially controlled asthma. Of these, 39 patients with normal body weight (Group 1) and 46 patients with grade 1–2 obesity (Group 2). The control group consisted of 30 healthy volunteers. The function of the small airways was assessed according to spirometry and body plethysmography. The composition of fatty acids and plasmalogens in blood plasma was assessed by gas chromatography-mass spectrometry. In the blood serum, the content of thromboxane B2 and leukotriene B4 was determined. Statistical processing was performed using the Statistica 6.1 program (StatSoft Inc., USA). Relationships between pairs of traits were examined using the Spearman correlation test (r). Differences were considered statistically significant at p < 0.05.Results. In the combined course of asthma and obesity, dysfunction of the small airways develops against the background of generalized bronchial obstruction. A violation of lipid metabolism was revealed, manifested by an increase in the levels of saturated, monoenoic, n-6 polyunsaturated fatty acids against the background of a deficiency of n-3 polyunsaturated fatty acids and phospholipids with an alkenyl bond – plasmalogens. It has been shown that bronchial asthma, aggravated by obesity, occurs against the background of increased synthesis of inflammatory lipid mediators – eicosanoids (thromboxane B2 and leukotriene B4). Evaluation of the correlation relationships between the studied lipids and the function of small airways revealed a high degree of relationship between their participants.Conclusion. An important pathogenetic link in the formation of small airway dysfunction in bronchial asthma aggravated by obesity is a violation of fatty acid metabolism and plasmalogen synthesis, an increase in the formation of inflammatory lipid mediators.

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Features of cytokine and adipokine regulation in asthma associated with obesity

Cited by 3 publications

References 16 publications

Effect of obesity on airway and systemic inflammation in adults with asthma: a systematic review and meta-analysis

Effect of obesity on airway and systemic inflammation in adults with asthma: a systematic review and meta-analysis

Pathophysiological relation between the systemic inflammation and the state of small airways in mild asthma with obesity

The role of fatty acids and lipid inflammatory mediators in the development of small airway dysfunction in asthma complicated with obesity

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