Adipogenic differentiation potential of adipose‐derived mesenchymal stem cells from ovariectomized mice

Abstract

These findings suggest that enhanced adipogenic differentiation of ADSCs is likely to be the important cause for increased adipogenesis in vivo and subsequent obesity-like changes in body mass, in mice, after ovariectomy.

Regulation of Body Composition and Bioenergetics by Estrogens

“…OVX appears to expand adipose tissue by increasing adipocyte size and preadipocyte differentiation 39, 44 . Controlling food intake in OVX animals through paired feeding with sham animals attenuated, but did not prevent, the fat gain observed in ad libitum fed OVX rats 40 .…”

Decellularized human amniotic membrane: how viable is it as a delivery system for human adipose tissue‐derived stromal cells?

“…Clinically, human adipose-derived stromal cells (hADSC) are often the choice of cell source for transplantation, in cell-based therapy, such as burn wound healing (12)(13)(14)(15)(16)(17). In addition, several studies have demonstrated that growth factors secreted by such cells are involved in angiogenesis and injury healing (18)(19)(20)(21)(22), yet a 3D scaffold for expansion and delivery of such cells is still considered to be a largely unmet clinical need. With this concept, dHAM could also serve as a cell-carrier 3D scaffold for delivery of hADSC, essential in regenerative medicine.…”

Effect of adipose-derived mesenchymal stromal cells on tendon healing in aging and estrogen deficiency: an in vitro co-culture model

“…Besides the well-known events that occur in bone tissue [1,2], recent studies have underlined the role of estrogen as an important player in the homeostasis of other musculoskeletal tissues because of its involvement in collagen turnover. Morphology, mechanics and function of connective tissues, such as skin, muscles and tendons, are negatively influenced by hormone lack, thus compromising the patient's daily living activities [3e5].…”