Adipocytokine Levels in Obese and Non-obese Subjects: an Observational Study

Abstract

We evaluated the levels of some inflammatory adipocytokines in 363 obese and 365 non-obese subjects. We measured: body mass index (BMI), waist circumference (WC), fasting plasma glucose, fasting plasma insulin (FPI), homeostasis model assessment (HOMA) index, blood pressure, lipid profile, retinol binding protein-4 (RBP-4), vaspin, omentin-1, leptin, interleukin-6 (IL-6), visfatin, resistin, adiponectin (ADN), adipsin, tumor necrosis factor-α (TNF-α), and high sensitivity C-reactive protein (Hs-CRP). We observed higher BMI, WC, FPI, HOMA index, TC, LDL-C, RBP-4, leptin, IL-6, adipsin, Hs-CRP, vaspin, resistin and TNF-α levels, and lower visfatin, and ADN levels in obese compared to non-obese subjects. Higher WC correlated with lower ADN and visfatin levels, and higher vaspin levels. Higher HOMA index correlated with higher resistin, adipsin, RBP-4, and leptin concentrations, while higher leptin levels correlated with higher TNF-α, Hs-CRP, and IL-6 concentration, and lower ADN values. We confirmed obese subjects' predisposition to develop dysmetabolic disease and hormonal dysfunctions.

The levels of visceral adipose tissue-derived serpin, omentin-1 and tumor necrosis factor-α in the gingival crevicular fluid of obese patients following periodontal therapy

“…Moreover, higher vaspin and TNF-α levels were found in obese compared to non-obese individuals. In addition, a significant correlation was observed between waist circumference (WC) and higher vaspin levels (41). This is consistent with our finding that GCF vaspin and TNF-α increased with obesity.…”

“…Changes in vaspin levels have been investigated in many diseases (38)(39)(40)(41)(42). Vaspin was associated with obesity, type 2 diabetes mellitus, rheumatoid arthritis, and systemic inflammation (39,43).…”

Novel targets for the development of drugs for Type 2 Diabetes Mellitus

“…However, when adipocytes were stimulated with LPS in the presence of RAW264.7 macrophages, we observed a significant decrease of adipsin mRNA ( Figure 3B). This decrease of adipsin is in line with lower levels of adipsin often found in human subjects suffering from T2DM (Derosa et al, 2013). These observations suggest that a macrophage-derived factor might be responsible for the reduced expression of adipsin, possibly TNFα and/or IL6.…”

Study of salivary and serum vaspin and total antioxidants in anorexia nervosa

“…The sensitivity, specificity, and area of characteristic AUC (mean ± SD) values for serum TAS amounted to 37%, 90%, and 0.583 ± 0.075, respectively. In the case of serum VASP, these values amounted to 38%, 80%, and 0.542 ± 0.075 adaptation to a condition of undernutrition [12,54,55]. Therefore, a simple examination of saliva might be one noninvasive method of nutritional assessment in patients with AN.…”