Adhesion Receptors in Malignant Transformation and Dissemination of Gastrointestinal Tumors

Streit, Michael; Schmidt, Roland; Hilgenfeld, R. U.; Thiel, Eckhard; Kreuser, E. D.

doi:10.1007/978-3-642-80035-1_3

Cited by 43 publications

(24 citation statements)

References 106 publications

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“…Several other investigators also reported that CD44 v6 expression was associated with an increasing metastatic potential of colorectal carcinoma. [5][6][7][8][9][10][11][12] On the other hand, Gotley et al 13 found that an expression of the CD44 variant epitopes did not correlate with either the tumor progression or metastasis to the liver from colorectal carcinoma. Several investigators reported that CD44 expression was either lost in large invading tumors or decreased during the formation of liver metastasis from colorectal carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical Expression of the CD44 Variant 6 in Colorectal Adenocarcinoma

Ishida

2000

Surg Today

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The CD44 variant 6 (CD44 v6) has been postulated to be involved in both carcinogenesis and tumor progression. In the present study, CD44 v6 was stained immunohistochemically in 63 colorectal cancer tissues to assess significance of CD44 v6 in the carcinogenesis and progression of colorectal carcinoma. None of the normal colonocytes showed an expression of CD44 v6. CD44 v6 expression was very strong in 24, moderate in 13, and negative in 26 tumor tissues. A negative or moderate expression of CD44 v6 was significantly associated with a larger tumor size (P < 0.05) and invasion through the bowel wall (P < 0.01). There was no correlation between the expression of CD44 v6 and gross type, histologic differentiation, lymph node involvement, liver metastasis, and clinical stage of the disease. The present study showed that the expression of CD44 v6 was characteristic of neoplastic changes in the colonocytes and that a diminished expression of CD44 v6 was associated with the penetration of colorectal cancer through the bowel wall, but not with either lymph node or distant metastasis.

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Section: Discussionmentioning

confidence: 99%

Immunohistochemical Expression of the CD44 Variant 6 in Colorectal Adenocarcinoma

Ishida

2000

Surg Today

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“…36 Moreover, expression of the 67 kDa laminin receptor strongly correlated with the degree of differentiation, the invasive phenotype, and the metastatic abilities of colorectal cancer cells. 38 The decreased ability to adhere to laminin caused by TZD treatment may therefore result in a decrease in the malignant potential of colon cancer cells. In the present study, we did not observe any changes in expression of the integrins responsible for adhesion to the ECM proteins, and the probable mechanism is a functional downregulation of these receptors.…”

Section: Effect Of Tzd On Cancer Cell Adhesion To Ecm Proteinsmentioning

confidence: 99%

Decreased Synthesis of Matrix Metalloproteinase-7 and Adhesion to the Extracellular Matrix Proteins of Human Colon Cancer Cells Treated with Troglitazone

Sunami¹,

Tsuno²,

Kitayama³

et al. 2002

Surgery Today

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“…Abnormalities of E-cadherin expression have been described in colorectal carcinoma [31] and have been correlated with increased invasiveness, metastatic potential and poor patient prognosis in this tumor type [27].…”

Section: Introductionmentioning

confidence: 99%

A comparative study of E-cadherin and stromelysin-3 expression in de novo and ex adenoma carcinoma of the colorectum

et al. 2001

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An apparent exception to the colorectal adenoma-carcinoma carcinogenetic pathway is the so-called "de novo" carcinoma which has no evidence of adenoma in its vicinity. Despite the fact that they are often quite small, these lesions appear to be more aggressive (i.e., greater likelihood of lymph-node metastases) than carcinomas that clearly arise from surrounding adenomas exadenoma carcinoma. The purpose of the present comparative immunohistochemical study was to compare rates of cell adhesion molecule (E-cadherin) and protease [stromelysin-3 (ST-3)] expression in groups of de novo (n=64) and ex adenoma (n=42) lesions in order to see whether their more aggressive behavior is associated with decreased cell adhesion and increased protease expression. The rates of extensive ST-3 expression and decreased E-cadherin expression were significantly higher in the de novo group (P=0.014 and 0.005, respectively). Histopathologically, the de novo group also had a significantly higher percentage of cases with an infiltrative invasion pattern. These differences highlight the more aggressive phenotype of the de novo colorectal carcinoma and fit with their greater invasive potential.

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Adhesion Receptors in Malignant Transformation and Dissemination of Gastrointestinal Tumors

Cited by 43 publications

References 106 publications

Immunohistochemical Expression of the CD44 Variant 6 in Colorectal Adenocarcinoma

Immunohistochemical Expression of the CD44 Variant 6 in Colorectal Adenocarcinoma

Decreased Synthesis of Matrix Metalloproteinase-7 and Adhesion to the Extracellular Matrix Proteins of Human Colon Cancer Cells Treated with Troglitazone

A comparative study of E-cadherin and stromelysin-3 expression in de novo and ex adenoma carcinoma of the colorectum

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