Adenosquamous carcinoma development as a recurrence of squamous cell carcinoma in the oral floor

Abstract

Rationale:Oral adenosquamous carcinoma (ASC) is rare and its origins are controversial. We here present a patient with oral ASC that developed after surgery for oral squamous cell carcinoma (SCC).Patient concerns:A 70-year-old man with SCC on the oral floor underwent surgical resection. However, the enlarged ulcer presented on the oral floor 9 month after surgery.Diagnoses:The biopsy of the ulcer revealed a SCC. Imaging examinations detected enhancement of a large lesion expanded to the tongue, but no evidence of regional lymph node or distant metastasis was shown. Based on these results, local recurrence of the cancer was diagnosed (cT4aN0M0).Interventions:The surgery for the recurrent tumor was performed.Outcomes:The pathological examination of the surgical specimen indicated recurrent tumor was ASC. Thus, histopathological and immunohistochemical analyses of both the initial SCC and the subsequent ASC were performed in an attempt to explore the origin of the ASC. As the results, pathological review of both tumors suggested the subsequent ASC was developed from the tumor cells with adenoid phenotype in the initial SCC.Lessons:This report suggests that the oral ASC was origin from the oral SCC, which can contribute to new knowledge for pathogenesis of oral cancer.

Adenosquamous Carcinoma with the Acantholytic Feature in the Oral Cavity: A Case Report and Comprehensive Literature Review

“…However, CK7 was negative, and CAM5.2 was positive only in a small number of cancer cells in the present case. The glandular components of reported cases of oral ASC were typically positive for CK7 [ 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ]. The mucin-containing cells were CEA-positive and p40-negative, similar to the immunohistochemical results for ASC reported by Satomi et al [ 15 ].…”

“…From our comprehensive literature review of ASC arising in the oral cavity ( Table 1 ), 50 cases, including the present case, have been reported [ 2 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 23 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ], and the clinical information of the review is summarized in Table 2 . The median age of the patients was 60 (range 22–97).…”

Silencing of LncRNA SNHG16 Downregulates Cyclin D1 (CCND1) to Abrogate Malignant Phenotypes in Oral Squamous Cell Carcinoma (OSCC) Through Upregulating miR-17-5p

“…Oral squamous cell carcinoma (OSCC) is the predominant subtype of oral cancer, 1 which is characterized by high incidence and mortality, and brought huge health burden to human beings worldwide. 2–4 Although the advances in the traditional therapies, such as surgery, chemotherapy and radiotherapy had been reached, the prognosis in OSCC patients is still very poor as the result of its unclear underlying mechanisms. 5–7 Therefore, researchers recently focused on exploring the molecular characteristics of OSCC pathogenesis, 4 , 8 and identified that multiple long non-coding RNAs (LncRNAs) participated in modulating OSCC development.…”