Adenocarcinoma of the parotid salivary gland in a cow

Abstract

A 6-year-old Girolando dairy cow was presented for evaluation of a large subcutaneous facial mass. Fine-needle aspirates of the mass contained many neoplastic cells with high nuclear:cytoplasmic ratios arranged in sheets and loosely cohesive clusters with streaming erythrocytes and neutrophils in the background. Neoplastic cells were 13-25 μm in diameter and were round to cuboidal with variably distinct borders. Based on the signalment, anatomic location, and cytologic findings, differential diagnoses included salivary adenocarcinoma, squamous cell carcinoma, and mucoepidermoid carcinoma. The cow was euthanized and a necropsy was performed. The primary neoplasm arose from the left parotid salivary gland and meastatic tumor was found in the regional lymph nodes and lung. Histologically, the tumor was composed of anastomosing and irregular solid islets surrounded by scant stroma. Cells were negative for periodic acid-Schiff (PAS), PAS-diastase, and Alcian blue pH 2.5 stains, used to detect mucin. On immunohistochemical analysis, neoplastic luminal salivary gland cells expressed cytokeratin, but not S100, α-smooth muscle actin, or vimentin. Peripheral cells of neoplastic islets were immunoreactive for p63. The final diagnosis was nonsecretory adenocarcinoma of the parotid salivary gland.

Parotid gland adenocarcinoma in a cow: case report

“…In this report, it is possibly due to the biological processes known as dedifferentiation and epithelial-mesenchymal transition, which may occur in neoplastic cells of malignant biological behavior (Korita et al, 2010). In contrast, in another case of salivary adenocarcinoma in cattle, neoplastic cells showed no immunostaining for vimentin and S100, with the diagnosis of non-secretory carcinoma of salivary gland (Salgado et al, 2012).…”

“…Therefore, it was considered as a differential diagnosis of salivary glands adenocarcinoma and squamous cell carcinoma, both undifferentiated. Although adenocarcinoma of salivary gland in cattle is rare, there are reports of similar microscopic description (Salgado et al, 2012).…”

“…However, such identification is difficult as the malignant tumor become anaplastic (Head et al, 2002). Moreover, salivary gland tumors in cattle have been described only by histopathology (Bundza, 1983;Salgado et al, 2012), descriptions of such neoplasias by FNAC are rare. The absence of cytologic descriptions complicates the diagnosis of these tumors, especially when they have a high degree of malignancy.…”

Spindelzelliges Sarkom am Unterkiefer einer 5 Jahre alten Holstein-Friesian-Kuh

“…Auch tumoröse Veränderungen kommen gelegentlich vor [3] [6]. Nicht zuletzt müssen entzündliche Veränderungen oder Verletzungen im Bereich des Larynx, Pharynx sowie des Retropharyngealbereichs und Entzündungen oder in seltenen Fällen tumoröse Veränderungen der Speicheldrüsen differenzialdiagnostisch berücksichtigt werden [16].…”

High-grade mucoepidermoid carcinoma of the salivary gland in a bull

“…Salivary gland neoplasms are uncommon in all veterinary species, occurring most often in dogs and cats, 11,13 rarely in cattle, 2,16,17 and sporadically in nontraditional species [5][6][7] ; they remain unreported in swine. 13 A retrospective study including almost 600 tumors in cattle over a 45-y period identified no salivary neoplasms.…”