Adenocarcinoma of the bladder following nephrogenic adenoma: a case report

Hungerhuber, Edwin; Bach, Ekkehard; Hartmann, Arndt; Frimberger, Dominic; Stief, Christian G.; Zaak, Dirk

doi:10.1186/1752-1947-2-164

Cited by 18 publications

(12 citation statements)

References 18 publications

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“…2 However, approximately 10% of the lesions are greater Hospital Universitario Central de Asturias, Oviedo, Spain than 4 cm in diameter, as in the case reported. 8 Upon immunohistochemical analysis, nephrogenic adenomas are positive for the renal tubule markers CK7, CD10, AMACR, PAX 2, and PAX 8 but negative for bladder urothelium antigens such as p63. 2 The transcription factors PAX 2 and PAX 8 are expressed in nearly 100% of nephrogenic adenomas in some series.…”

Section: Discussionmentioning

confidence: 99%

Nephrogenic Adenoma of Female Urethra

Puertas

Fernández

Llaneza

2016

J Low Genit Tract Dis

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Section: Discussionmentioning

confidence: 99%

Nephrogenic Adenoma of Female Urethra

Puertas

Fernández

Llaneza

2016

J Low Genit Tract Dis

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“…Clinical symptoms, when present, are non-specific such as lower urinary tract symptoms and hematuria [ 22 , 23 ]. Therapeutic options vary from watchful waiting to cystectomy [ 23 ], whereas in most cases a transurethral resection is favored [ 24 ], as it was the case in our 3 patients with a nephrogenic adenoma. A high recurrence rate up to 80% has been reported [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

“…A high recurrence rate up to 80% has been reported [ 23 ]. Although nephrogenic adenoma is usually thought to be a benign entity [ 22 ], there might be some potential for malignant transformation as its occurrence has been reported in association with transitional cell carcinoma [ 23 ] and moderately differentiated adenocarcinoma of the bladder in a patient with NLUTD [ 24 ]. Because of the high recurrence rate of the nephrogenic adenoma and its assumed potential for neoplastic transformation, regular follow-up should be considered.…”

Section: Discussionmentioning

confidence: 99%

Do We Need Surveillance Urethro-Cystoscopy in Patients with Neurogenic Lower Urinary Tract Dysfunction?

et al. 2015

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PurposeTo examine the value of surveillance urethro-cystoscopy in patients with neurogenic lower urinary tract dysfunction (NLUTD) in regard to the conflicting literature as it is generally agreed that patients with NLUTD are at increased risk for bladder cancer.Materials and MethodsIn a cross-sectional study, a consecutive series of 129 patients (50 females, 79 males, mean age 51, range 18–88) suffering from NLUTD for at least 5 years was prospectively investigated using urethro-cystoscopy and bladder washing cytology at a single university spinal cord injury (SCI) center.ResultsDue to suspicious urethro-cystoscopy and/or bladder washing cytology findings, 13 (10%) of 129 patients underwent transurethral resection of the bladder lesion and/or random bladder biopsies. Overall, 9 relevant histological findings were found in 5% (7/129) of our patients: bladder melanosis (n = 1), nephrogenic adenoma (n = 3), keratinizing squamous metaplasia (n = 1), intestinal metaplasia (n = 3), and muscle-invasive adenocarcinoma of the bladder (n = 1).ConclusionsUsing surveillance urethro-cystoscopy, we found relevant histological findings in 5% of our patients suffering from NLUTD for at least 5 years. Thus, surveillance urethro-cystoscopy might be warranted, although the ideal starting point and frequency remain to be determined in further prospective studies.

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“…Although development of malignancy from NA in adults has been reported, no case of malignant transformation has been reported in pediatric patients. [10] The presentation of NA is usually with hematuria and lower urinary tract symptoms of frequency, nocturia and urgency. [1] Cystoscopy provides the initial visual diagnosis in suspicion of transitional cancer.…”

Section: Discussionmentioning

confidence: 99%

Recurrence of childhood nephrogenic adenoma in urinary bladder developed four years after previous surgery despite intravesical sodium hyaluronate therapy

Özçift

Kaçar

Tiryaki

2016

Turkish Journal of Urology

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Nephrogenic adenoma (NA) is a rarely seen benign metaplastic lesion of the urinary tract. Its etiology is uncertain, but induced by chronic inflammation, irritation, and trauma. NA is located in the urinary tract, most commonly in the bladder. NA usually presents with hematuria and lower urinary tract symptoms. In the literature it is mostly seen in adults but about 30 cases of NA's have been reported in children. Treatment of intravesical lesions consists of transurethral resection (TUR) and fulguration and rarely partial or total cystectomy may be required in ineffective TUR. Recurrence rate is high during long-term follow-up. The intravesical application of sodium hyaluronate produces a protective effect on the glycosaminoglycan layer and delays or prevents its recurrence. We report a case of recurrent NA of the bladder in a pediatric male patient who was presented four years after previous surgery despite intravesical sodium hyaluronate therapy.

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Adenocarcinoma of the bladder following nephrogenic adenoma: a case report

Cited by 18 publications

References 18 publications

Nephrogenic Adenoma of Female Urethra

Nephrogenic Adenoma of Female Urethra

Do We Need Surveillance Urethro-Cystoscopy in Patients with Neurogenic Lower Urinary Tract Dysfunction?

Recurrence of childhood nephrogenic adenoma in urinary bladder developed four years after previous surgery despite intravesical sodium hyaluronate therapy

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