Nephrogenic Adenoma of Female Urethra

Puertas, Carmen; Fernández, Sara Pereiro; Llaneza, Plácido

doi:10.1097/lgt.0000000000000219

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2023

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“…Nephrogenic adenomas may present as a palpable mass, rarely at the anterior vaginal wall or in a urethral diverticulum as in our case [ 3 ]. Patients with nephrogenic adenoma may have recurrent urinary tract infections (UTIs), obstructive urinary symptoms, hematuria, dyspareunia, or suprapubic pain [ 3 - 6 ].…”

Section: Discussionmentioning

confidence: 99%

Nephrogenic Adenoma Arising From a Female Urethral Diverticulum: A Case Report and Potential Diagnostic Pitfalls

Thanedar¹,

Gosnell²,

Clement³

et al. 2023

Cureus

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Nephrogenic adenoma is a benign lesion of the urothelial tract characterized by tubules surrounded by thick, hyalinized basement membranes. There is a great variety of architectural patterns within nephrogenic adenomas, including patterns that mimic malignancy, such as focal clear or hobnail cells, areas of significant nuclear atypia, mitosis, and isolated cystic changes. This represents a diagnostic pitfall, where a malignant lesion can be mistaken for a nephrogenic adenoma, leading to a delay in diagnosis and treatment that adversely affects the outcome. In this case report, we describe a nephrogenic adenoma arising in a female urethral diverticulum and discuss the differential diagnosis, which includes clear cell carcinomas, microcystic variant urothelial carcinomas, and Skene’s gland cysts.

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Section: Discussionmentioning

confidence: 99%