Recurrence of childhood nephrogenic adenoma in urinary bladder developed four years after previous surgery despite intravesical sodium hyaluronate therapy

Abstract

Nephrogenic adenoma (NA) is a rarely seen benign metaplastic lesion of the urinary tract. Its etiology is uncertain, but induced by chronic inflammation, irritation, and trauma. NA is located in the urinary tract, most commonly in the bladder. NA usually presents with hematuria and lower urinary tract symptoms. In the literature it is mostly seen in adults but about 30 cases of NA's have been reported in children. Treatment of intravesical lesions consists of transurethral resection (TUR) and fulguration and rarely partial or total cystectomy may be required in ineffective TUR. Recurrence rate is high during long-term follow-up. The intravesical application of sodium hyaluronate produces a protective effect on the glycosaminoglycan layer and delays or prevents its recurrence. We report a case of recurrent NA of the bladder in a pediatric male patient who was presented four years after previous surgery despite intravesical sodium hyaluronate therapy.

Nephrogenic adenoma of the renal pelvis

“…In addition to surgical treatment for NA, Campobasso et al [3] successfully treated a 12-year-old boy diagnosed with bladder NA with sodium hyaluronate. Then several reports subsequently confirmed that NA could be successfully treated by injecting sodium hyaluronate into the bladder of children with bladder NA [27] . A recent study also reported the first case of injection of sodium hyaluronate in the bladder to successfully treat adult NA, [4] indicating that sodium hyaluronate could be an alternative treatment for patients who were not suitable for surgical resection of lesions.…”

“…Then several reports subsequently confirmed that NA could be successfully treated by injecting sodium hyaluronate into the bladder of children with bladder NA. [ 27 ] A recent study also reported the first case of injection of sodium hyaluronate in the bladder to successfully treat adult NA, [ 4 ] indicating that sodium hyaluronate could be an alternative treatment for patients who were not suitable for surgical resection of lesions. Currently, more case reports are needed to provide further evidence that topical application of sodium hyaluronate as an effective treatment option.…”